Compound ID	Pharmacological profile	Compound name	Binding data	Activity data	Bibliographic ref	Cross-reactivity
CHEMBL213816	agonist	Compound 5j	EC50 = 0.13 +/- 0.05 µM	Relative efficacy = 90 %	PMID: 17154495
CHEMBL214076	agonist	Compound 5k	EC50 = 0.13 +/- 0.04 µM	Relative efficacy = 95 %	PMID: 17154495
CHEMBL259067	antagonist	Compound 2		IC50 = 0.76 +/- 0.10 µM	PMID: 18374567
CHEMBL260545	antagonist	Compound 23		IC50 = 9.71 +/- 5.63 µM	PMID: 18374567
CHEMBL260592	antagonist	Compound 29		IC50 = 0.53 +/- 0.20 µM	PMID: 18374567
CHEMBL261113	antagonist	Compound 27		IC50 = 4.71 +/- 0.86 µM	PMID: 18374567
CHEMBL261114	antagonist	Compound 25		IC50 = 1.06 +/- 0.03 µM	PMID: 18374567	ROR_alpha
CHEMBL261115	antagonist	Compound 26		IC50 = 0.68 +/- 0.12 µM	PMID: 18374567	ROR_alpha
CHEMBL261305	antagonist	Compound 24		IC50 = 1.77 +/- 0.16 µM	PMID: 18374567
CHEMBL262079	antagonist	Compound 31		IC50 = 0.20 +/- 0.04 µM	PMID: 18374567
CHEMBL265938	antagonist	Compound 33		IC50 = 0.19 +/- 0.01 µM	PMID: 18374567	ROR_alpha
CHEMBL408702	antagonist	Compound 1		IC50 = 0.26 +/- 0.06 µM	PMID: 18374567
CHEMBL408704	antagonist	Compound 43		IC50 = 3.57 +/- 0.89 µM	PMID: 18374567
CHEMBL408947	antagonist	Compound 34		IC50 = 0.11 +/- 0.04 µM	PMID: 18374567	ROR_alpha
CHEMBL410467	antagonist	Compound 32		IC50 = 0.20 +/- 0.11 µM	PMID: 18374567
CHEMBL411501	antagonist	Compound 40		IC50 = 8.46 +/- 1.67 µM	PMID: 18374567
CHEMBL411889	antagonist	Compound 35		IC50 = 0.36 +/- 0.05 µM	PMID: 18374567	ROR_alpha
CHEMBL412079	antagonist	Compound 30		IC50 = 0.34 +/- 0.02 µM	PMID: 18374567	ROR_alpha
CHEMBL412080	antagonist	Compound 28		IC50 = 0.36 +/- 0.03 µM	PMID: 18374567
ZINC08195650	antagonist	sphingosine	270 pmol/ mg		PMID: 16887917
ZINC14978517	agonist	Compound 5c	EC50 = 0.030 +/- 0.001 µM	Relative efficacy = 95%	PMID: 17154495
ZINC14978520	agonist	Compound 5d	EC50 = 0.010 +/- 0.002 µM	Relative efficacy = 90%	PMID: 17154495
ZINC14978530	agonist	Compound 5h	EC50 = 0.8 +/- 0.1 µM	Relative efficacy = 80 %	PMID: 17154495
ZINC14978552	agonist	Compound 7	pEC50 = 7.4	Relative efficacy = 70 %	PMID: 21391689
ZINC14978555	agonist	Compound 5n	EC50 = 0.18 +/- 0.07 µM	Relative efficacy = 65%	PMID: 17154495
ZINC14978565	agonist	Compound 5q	EC50 = 0.56 +/- 0.02 µM	Relative efficacy = 70 %	PMID: 17154495
ZINC29048460	antagonist	Compound 14		IC50 = 13.7 +/- 1.3 µM	PMID: 18374567
ZINC29048463	antagonist	Compound 38		IC50 = 0.59 +/- 0.12 µM	PMID: 18374567
ZINC71296729	agonist	Compound 12c	pEC50 = 6.7	Relative efficacy =  67 %	PMID: 21391689
ZINC71296766	agonist	RJW102	pEC50 = 6.7	Relative efficacy =  76%	PMID: 21391689
ZINC71296773	agonist	Compound 18i	pEC50 = 6.8	Relative efficacy =  66%	PMID: 21391689
ZINC71316556	agonist	Compound 12e	pEC50 = 6.6	Relative efficacy =  62 %	PMID: 21391689
ZINC71318083	agonist	Compound 12i	pEC50 = 7.1	Relative efficacy =  66 %	PMID: 21391689
ZINC71318097	agonist	Compound 24-endo	pEC50 = 7.2	Relative efficacy =  77%	PMID: 21391689
ZINC71319136	agonist	Compound 18v	pEC50 = 6.8	Relative efficacy =  67%	PMID: 21391689
ZINC71329049	agonist	Compound 18a	pEC50 = 7.2	Relative efficacy =  78 %	PMID: 21391689
ZINC71329107	agonist	RJW100	pEC50 = 7.5	Relative efficacy =  100%	PMID: 21391689
ZINC71329899	agonist	Compound 18u	pEC50 = 7.4	Relative efficacy =  86%	PMID: 21391689
ZINC71330479	agonist	Compound 29-endo	pEC50 = 6.5	Relative efficacy =  95%	PMID: 21391689