Compound ID	Pharmacological profile	Compound name	Binding data	Activity data	Bibliographic ref	Cross-reactivity
CHEMBL134834	agonist	HX640	Ki = 790 nM		PMID: 9435893	RXR_alpha
CHEMBL298373	antagonist	LE540	Ki = 1700 nM		PMID: 9435893	RXR_alpha
CHEMBL308377	agonist	Compound 3	Kd = 210 nM	EC50 = 25 nM	PMID: 11428923	RXR_alpha
CHEMBL308883	agonist	Compound 6	Kd = 56 nM	EC50 = 100 nM	Bioorg. Med. Chem. Lett. 1996, 6, 2, 213	RXR_alpha
CHEMBL326525	antagonist	HX531		IC50 = 0.044 +/- 0.002 µM	PMID: 19095448	RXR_alpha
CHEMBL334330	agonist	HX600	Ki = 640 nM		PMID: 9435893	RXR_alpha
CHEMBL334428	agonist	HX641	Ki = 150 nM		PMID: 9435893	RXR_alpha
CHEMBL334534	agonist	HX620	Ki = 1200 nM		PMID: 9435893	RXR_alpha
CHEMBL337859	agonist	HX630	Ki = 400 nM		PMID: 9435893	RXR_alpha
CHEMBL69091	agonist	Compound 5	Kd = 2.5 nM	EC50 = 2.0 nM	Bioorg. Med. Chem. Lett. 1996, 6, 2, 213	RXR_alpha
CHEMBL75133	agonist	Compound 2	Kd = 3.6 nM	EC50 = 0.8 nM	PMID: 11428923	RXR_alpha
CHEMBL89241	agonist	LG100567	Ki = 10.2 +/- 3.7 nM	EC50 = 87 +/- 44 nM	PMID: 8709094	RXR_alpha
ZINC01539543	agonist	Compound 3		EC50 = 180 nM	Bioorg. Med. Chem. Lett. 1995, 5, 22, 2729	RAR_beta
ZINC01539579	agonist	targretin	Ki = 21 nM	EC50 = 25 nM	PMID: 10052980	RAR_gamma
ZINC01546069	agonist	Compound 6b	Ki = 4 nM	EC50 = 13 nM	Bioorg. Med. Chem. Lett. 1996, 6, 2, 213	RXR_alpha
ZINC01895566	agonist	Compound 14b		relative EC30 = 0.068	PMID: 9703470	RXR_alpha
ZINC03834061	agonist	Compound 3	Ki = 5 nM	EC50 = 14 nM	PMID: 10052980	RXR_alpha
ZINC03834062	agonist	Compound 9	Ki = 61 nM	EC50 = 37 nM	PMID: 10052980	RXR_alpha
ZINC03834065	agonist	Compound 14	Ki = 14 nM	EC50 = 25 M	PMID: 10052980	RXR_alpha
ZINC03834066	agonist	Compound 5	Ki = 6 nM	EC50 = 32 nM	PMID: 10052980	RXR_alpha
ZINC03834068	agonist	Compound 8	Ki = 58 nM	EC50 = 12 nM	PMID: 10052980	RXR_alpha
ZINC03834070	agonist	TTCNB	Ki = 191 nM	EC50 = 213 nM	PMID: 10052980	RAR_gamma
ZINC03834071	agonist	Compound 10	Ki = 283 nM	EC50 = 157 nM	PMID: 10052980	RXR_alpha
ZINC04632539	agonist	Compound 7	Ki = 363 nM	EC50 = 207 nM	PMID: 10052980	RXR_gamma
ZINC04821771	agonist	Compound 4	Ki = 8 nM	EC50 = 10 nM	PMID: 10052980	RXR_alpha
ZINC12358651	agonist	ATRA	Ki = 881 +/- 9.0 nM	EC50 = 1394 +/- 49 nM	PMID: 8709094	PPAR_gamma
ZINC12661824	agonist	9 cis-retinoic acid	IC50 = 12 +/- 3.0 nM	EC50 = 200 +/- 30 nM	PMID: 8308867	RAR_alpha
ZINC13734373	agonist	3-ethyl-TTNPB	IC50 = 50 +/- 10 nM	EC50 = 2000 +/- 150 nM	PMID: 8308867	RAR_alpha
ZINC13738449	agonist	Compound 12a	Ki = 199 nM	EC50 = 486 nM	Bioorg. Med. Chem. Lett. 1996, 6, 2, 213	RAR_alpha
ZINC13742307	agonist	Compound 4		EC50 = 23 nM	Bioorg. Med. Chem. Lett. 1995, 5, 22, 2729	RAR_beta
ZINC13757372	agonist	Compound 11	2	EC50 = 8 nM	PMID: 8765503	RAR_beta
ZINC13758053	agonist	Compound 1	Kd = 3868 nM	EC50 = 1600 nM	PMID: 8784454	RAR_beta
ZINC13758055	agonist	Compound 2	Kd = 296 nM	EC50 = 300 nM	PMID: 8784454	RXR_alpha
ZINC13758062	agonist	Compound 4	Kd = 2518 nM	EC50 = 57 nM	PMID: 8784454	RXR_alpha
ZINC13758065	agonist	Compound 5	Kd = 32 nM	EC50 = 1300 nM	PMID: 8784454	RXR_alpha
ZINC13780871	agonist	Compound 10		relative EC30 = 7.4	PMID: 9703470	RAR_alpha
ZINC13780872	agonist	Compound 14a		relative EC30 = 0.12	PMID: 9703470	RXR_alpha
ZINC13780873	agonist	Compound 14c		relative EC30 = 0.45	PMID: 9703470	RXR_alpha
ZINC13780874	agonist	Compound 14d		relative EC30 = 59	PMID: 9703470	RXR_alpha
ZINC13794324	agonist	Compound 17	Ki = 120 nM	EC50 = 165 nM	PMID: 10052980	RXR_alpha
ZINC13794339	agonist	Compound 12	Ki = 15 nM	EC50 = 18 nM	PMID: 10052980	RXR_alpha
ZINC13794342	agonist	Compound 13	Ki = 91 nM	EC50 = 106 nM	PMID: 10052980	RXR_alpha
ZINC13911442	agonist	Compound 6a	Ki = 7 nM	EC50 = 19 nM	Bioorg. Med. Chem. Lett. 1996, 6, 2, 213	RXR_alpha
ZINC26649488	agonist	Compound 6		EC50 = 3 nM	Bioorg. Med. Chem. Lett. 1995, 5, 22, 2729	RAR_beta
ZINC26653564	agonist	Compound 8		EC50 = 180 nM	Bioorg. Med. Chem. Lett. 1995, 5, 22, 2729	RXR_alpha
ZINC26653569	agonist	Compound 9		EC50 = 130 nM	Bioorg. Med. Chem. Lett. 1995, 5, 22, 2729	RXR_alpha
ZINC26653776	agonist	Compound 5		EC50 = 2300 nM	Bioorg. Med. Chem. Lett. 1995, 5, 22, 2729	RAR_alpha
ZINC26657237	agonist	Compound 7		EC50 = 210 nM	Bioorg. Med. Chem. Lett. 1995, 5, 22, 2729	RAR_alpha
ZINC26657257	agonist	Compound 11a	Ki = 124 nM	EC50 = 127 nM	Bioorg. Med. Chem. Lett. 1996, 6, 2, 213	RXR_alpha
ZINC28342099	agonist	Compound 4		Fold induction = 13.5	PMID: 15261282
ZINC28362705	agonist	Compound 1		Fold induction = 5.8	PMID: 15261282
ZINC36241986	agonist	Compound 32	Ki = 605 nM	EC50 = 151 nM	PMID: 16364638	RXR_alpha
ZINC36241990	agonist	Compound 34	Ki = 88 nM	EC50 = 95 nM	PMID: 16364638	RXR_alpha
ZINC36241992	agonist	Compound 35	Ki = 24 nM	EC50 = 235 nM	PMID: 16364638	RXR_alpha
ZINC36241998	agonist	Compound 49	Ki = 21 nM	EC50 = 179 nM	PMID: 16364638	RXR_alpha
ZINC36242000	agonist	Compound 48	Ki = 188 nM	EC50 = 1291 nM	PMID: 16364638	RXR_gamma
ZINC36242004	agonist	Compound 43	Ki = 185 nM	EC50 = 239 nM	PMID: 16364638	RXR_alpha
ZINC36242011	agonist	Compound 36	Ki = 34 nM	EC50 = 69 nM	PMID: 16364638	RXR_alpha
ZINC39257798	agonist	CD3254			PMID: 19408900
ZINC40423958	antagonist	Compound 10e			PMID: 19408900	RXR_alpha
ZINC40896500	antagonist	Compound 5g		IC50 = 3.9 +/- 2.0 µM	PMID: 19095448	RXR_alpha
ZINC40896883	antagonist	Compound 5h		IC50 = 0.87 +/- 0.36 µM	PMID: 19095448	RXR_alpha
ZINC40933591	antagonist	Compound 5f		IC50 = 3.0 +/- 1.4 µM	PMID: 19095448	RXR_alpha
ZINC44418529	antagonist	Compound 5i		IC50 = 0.75 +/- 0.46 µM	PMID: 19095448	RXR_alpha
ZINC53159698	agonist	Compound 41	Ki = 105 nM	EC50 = 98 nM	PMID: 16364638	RXR_alpha
ZINC53255787	agonist	Compound 44	Ki = 152 nM	EC50 = 117 nM	PMID: 16364638	RXR_alpha
ZINC53267943	agonist	Compound 47	Ki = 721 nM	EC50 = 169 nM	PMID: 16364638	RXR_alpha
ZINC53267949	agonist	Compound 39	Ki = 60 nM	EC50 = 52 nM	PMID: 16364638	RXR_alpha
ZINC53268017	agonist	Compound 46	Ki = 161 nM	EC50 = 212 nM	PMID: 16364638	RXR_alpha
ZINC53268020	agonist	Compound 40	Ki = 301 nM	EC50 = 216 nM	PMID: 16364638	RXR_alpha
ZINC53268030	agonist	Compound 45	Ki = 72 nM	EC50 = 206 nM	PMID: 16364638	RXR_alpha
ZINC53268224	agonist	Compound 9	Ki = 12 nM	EC50 = 21 nM	PMID: 16364638	RXR_alpha