Compound ID Pharmacological profile Compound name Binding data Activity data Bibliographic ref Cross-reactivity
CHEMBL105979 agonist Compound 11a Kd = 110 nM EC50 = 470 nM PMID: 7636877
CHEMBL106817 agonist Compound 12c Kd = 670 +/- 100 nM EC50 = 51 +/- 7 nM PMID: 7636877
CHEMBL106837 agonist Compound 6c Kd = 176 +/- 9 nM EC50 = 300 nM PMID: 7636877
CHEMBL115763 agonist SR11223 EC50 = 300 nM PMID: 7650690
CHEMBL134834 agonist HX640 Ki = 1800 nM PMID: 9435893
RXR_beta
CHEMBL2029403 antagonist Compound 13e ACS Med. Chem. Lett., 2011, 2, 12,896
CHEMBL2029405 agonist Compound 13g ACS Med. Chem. Lett., 2011, 2, 12,896
CHEMBL235204 antagonist Compound 6n IC50 = 0.19 µM PMID: 17651969
CHEMBL235240 antagonist Compound 5e IC50 = 2.8 µM PMID: 17651969
CHEMBL235459 antagonist Compound 5b IC50 = 7.3 µM PMID: 17651969
CHEMBL235675 antagonist Compound 5d IC50 = 3.3 µM PMID: 17651969
CHEMBL236490 antagonist Compound 4f IC50 = 0.9 µM PMID: 17651969
CHEMBL236697 antagonist Compound 6h IC50 = 0.14 µM PMID: 17651969
CHEMBL236698 antagonist Compound 6j IC50 = 0.4 µM PMID: 17651969
CHEMBL236919 antagonist Compound 4h IC50 = 4.2 µM PMID: 17651969
CHEMBL237555 antagonist Compound 4c IC50 = 1.9 µM PMID: 17651969
CHEMBL237761 antagonist Compound 6a IC50 = 2.4 µM PMID: 17651969
CHEMBL237762 antagonist Compound 6f IC50 = 0.55 µM PMID: 17651969
CHEMBL237763 antagonist Compound 6l IC50 = 2.3 µM PMID: 17651969
CHEMBL237770 antagonist Compound 4l IC50 = 3.1 µM PMID: 17651969
CHEMBL237800 antagonist Compound 4k IC50 = 0.72 µM PMID: 17651969
CHEMBL238008 antagonist Compound 6s IC50 = 1.4 µM PMID: 17651969
CHEMBL238009 antagonist Compound 6w IC50 = 0.076 µM PMID: 17651969
CHEMBL242274 antagonist Compound 16e IC50 = 0.53 µM PMID: 17651968
CHEMBL242676 antagonist Compound 8g IC50 = 1.0 µM PMID: 17651968
CHEMBL243133 antagonist Compound 15d IC50 = 1.1 µM PMID: 17651968
CHEMBL244565 antagonist Compound 8f IC50 = 0.45 µM PMID: 17651968
CHEMBL244621 antagonist Compound 16a IC50 = 0.43 µM PMID: 17651968
CHEMBL244801 antagonist Compound 6a IC50 = 2.0 µM PMID: 17651968
CHEMBL244832 antagonist Compound 16b IC50 = 0.32 µM PMID: 17651968
CHEMBL245241 antagonist Compound 7a IC50 = 1.4 µM PMID: 17651968
CHEMBL245242 antagonist Compound 7b IC50 = 0.45 µM PMID: 17651968
CHEMBL246210 agonist Compound 31b EC50 = 115.8 nM PMID: 17490875
CHEMBL246824 agonist Compound 31a EC50 = 19.2 nM PMID: 17490875
CHEMBL246827 agonist Compound 19 EC50 = 760 nM PMID: 17490875
CHEMBL247000 agonist Compound 18 EC50 = 37.7 nM PMID: 17490875
CHEMBL247400 agonist Compound 31e EC50 = 144.0 nM PMID: 17490875
CHEMBL248415 agonist Compound 6 EC50 = 0.9 nM PMID: 17485209
CHEMBL25337 agonist Compound 9 AC50 = 100 nM PMID: 10890153
CHEMBL269365 antagonist Compound 4a IC50 = 2.2 µM PMID: 17651969
CHEMBL294346 agonist Compound 49 Ki = 20 nM EC50 = 48 nM PMID: 15056000
CHEMBL298373 antagonist LE540 Ki = 3800 nM IC50 = 36 nM PMID: 9435893
RXR_beta
CHEMBL305115 agonist Compound 56 Ki = 20 nM EC50 = 4 nM PMID: 15056000
CHEMBL308377 agonist Compound 3 Kd = 60 nM EC50 = 4 nM PMID: 11428923
RXR_beta
CHEMBL308883 agonist Compound 6 Kd = 71 nM EC50 = 130 nM Bioorg. Med. Chem. Lett., 1996, 6, 2, 213
RXR_beta
CHEMBL311113 agonist Compound 5 Ki = 15 nM EC50 = 31 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
CHEMBL326525 antagonist HX531 IC50 = 0.29 +/- 0.04 µM PMID: 19095448
RXR_beta
CHEMBL334330 agonist HX600 Ki = 1900 nM PMID: 9435893
RXR_beta
CHEMBL334428 agonist HX641 Ki = 900 nM PMID: 9435893
RXR_beta
CHEMBL334534 agonist HX620 Ki = 3800 nM PMID: 9435893
RXR_beta
CHEMBL337859 agonist HX630 Ki = 900 nM PMID: 9435893
RXR_beta
CHEMBL389760 antagonist Compound 8a IC50 = 1.3 µM PMID: 17651968
CHEMBL389966 antagonist Compound 9a IC50 = 3.9 µM PMID: 17651968
CHEMBL390017 antagonist Compound 8b IC50 = 2.0 µM PMID: 17651968
CHEMBL391112 antagonist Compound 6d IC50 = 0.37 µM PMID: 17651969
CHEMBL391161 antagonist Compound 4d IC50 = 1.5 µM PMID: 17651969
CHEMBL391309 antagonist Compound 6e IC50 = 0.34 µM PMID: 17651969
CHEMBL391526 antagonist Compound 6x IC50 = 1.2 µM PMID: 17651969
CHEMBL391572 antagonist Compound 6y IC50 = 0.85 µM PMID: 17651969
CHEMBL391573 antagonist Compound 6z IC50 = 1.3 µM PMID: 17651969
CHEMBL391903 antagonist Compound 6c IC50 = 0.25 µM PMID: 17651969
CHEMBL392857 antagonist Compound 4g IC50 = 1.7 µM PMID: 17651969
CHEMBL392858 antagonist Compound 4i IC50 = 0.97 µM PMID: 17651969
CHEMBL393451 antagonist Compound 6t IC50 = 0.48 µM PMID: 17651969
CHEMBL393524 antagonist Compound 5c IC50 = 6.2 µM PMID: 17651969
CHEMBL393649 antagonist Compound 6u IC50 = 1.1 µM PMID: 17651969
CHEMBL393650 antagonist Compound 6v IC50 = 0.095 µM PMID: 17651969
CHEMBL394103 antagonist Compound 4j IC50 = 0.88 µM PMID: 17651969
CHEMBL394622 antagonist Compound 15b IC50 = 0.79 µM PMID: 17651968
CHEMBL394721 antagonist Compound 4e IC50 = 2.9 µM PMID: 17651969
CHEMBL395563 antagonist Compound 6b IC50 = 0.72 µM PMID: 17651968
CHEMBL395564 antagonist Compound 6c IC50 = 0.39 µM PMID: 17651968
CHEMBL395800 antagonist Compound 6e IC50 = 5.5 µM PMID: 17651968
CHEMBL395801 antagonist Compound 7d IC50 = 0.13 µM PMID: 17651968
CHEMBL395962 antagonist Compound 15e IC50 = 3.0 µM PMID: 17651968
CHEMBL396200 antagonist Compound 16d IC50 = 0.52 µM PMID: 17651968
CHEMBL396658 antagonist Compound 6k IC50 = 0.51 µM PMID: 17651969
CHEMBL396659 antagonist Compound 6m IC50 = 1.2 µM PMID: 17651969
CHEMBL396661 antagonist Compound 6g IC50 = 0.2 µM PMID: 17651969
CHEMBL396867 antagonist Compound 4m IC50 = 3.8 µM PMID: 17651969
CHEMBL397034 antagonist Compound 15a IC50 = 0.89 µM PMID: 17651968
CHEMBL397149 antagonist Compound 6o IC50 = 0.22 µM PMID: 17651969
CHEMBL397150 antagonist Compound 6p IC50 = 0.13 µM PMID: 17651969
CHEMBL397151 antagonist Compound 6r IC50 = 0.47 µM PMID: 17651969
CHEMBL397281 antagonist Compound 7e IC50 = 0.42 µM PMID: 17651968
CHEMBL397511 antagonist Compound 8d IC50 = 0.46 µM PMID: 17651968
CHEMBL397512 antagonist Compound 8e IC50 = 0.45 µM PMID: 17651968
CHEMBL397579 antagonist Compound 6i IC50 = 1.0 µM PMID: 17651969
CHEMBL398163 antagonist Compound 16f IC50 = 0.50 µM PMID: 17651968
CHEMBL399326 agonist Compound 31c EC50 = 5.0 nM PMID: 17490875
CHEMBL409214 antagonist Compound 7c IC50 = 0.17 µM PMID: 17651968
CHEMBL418058 antagonist rhein IC50 = 0.75 µM PMID : 21613212
CHEMBL427694 antagonist Compound 8c IC50 = 0.19 µM PMID: 17651968
CHEMBL428202 antagonist Compound 4b IC50 = 1.8 µM PMID: 17651969
CHEMBL428204 antagonist Compound 6b IC50 = 0.84 µM PMID: 17651969
CHEMBL429821 antagonist Compound 16c IC50 = 2.1 µM PMID: 17651968
CHEMBL432140 agonist Compound 48 Ki = 40 nM EC50 = 29 nM PMID: 15056000
CHEMBL436628 antagonist Compound 7f IC50 = 0.78 µM PMID: 17651968
CHEMBL437367 antagonist Compound 5a IC50 = 15 µM PMID: 17651969
CHEMBL437956 antagonist Compound 6q IC50 = 0.43 µM PMID: 17651969
CHEMBL438857 antagonist Compound 6d IC50 = 0.67 µM PMID: 17651968
CHEMBL583410 agonist Compound 16 Ki = 81 +/- 12 nM EC50 = 200 +/- 28 nM PMID: 19791803
CHEMBL60037 agonist Compound 76 Ki = 79 nM EC50 = 70 nM PMID: 15056000
CHEMBL60090 agonist Compound 51 Ki = 200 nM EC50 = 97 nM PMID: 15056000
CHEMBL62537 agonist Compound 47 Ki = 40 nM EC50 = 20 nM PMID: 15056000
CHEMBL62880 agonist Compound 46a,b Ki = 6 nM EC50 = 3 nM PMID: 15056000
CHEMBL64222 agonist Compound 69 Ki = 158 nM EC50 = 42 nM PMID: 15056000
CHEMBL64392 agonist Compound 54 Ki = 63 nM EC50 = 60 nM PMID: 15056000
CHEMBL64771 agonist Compound 50 Ki = 100 nM EC50 = 137 nM PMID: 15056000
CHEMBL69091 agonist Compound 5 Kd = 1.5 nM EC50 = 1.5 nM Bioorg. Med. Chem. Lett., 1996, 6, 2, 213
RXR_beta
CHEMBL75133 agonist Compound 2 Kd = 0.4 nM EC50 = 0.2 nM PMID: 11428923
RXR_beta
CHEMBL89241 agonist LG100567 Ki = 4.6 +/- 0.6 nM EC50 = 134 +/- 16 nM PMID: 8709094
RXR_beta
CID2950 antagonist danthron Kd = 6.2 µM IC50 = 0.11 µM PMID: 21084305
CID447226 agonist BMS649 Kd = 5-10 nM PMID: 11981034 
ZINC00001536 agonist honokiol EC50 = 11.8 µM PMID: 20695472
ZINC01539543 agonist Compound 7 EC50 = 201 nM PMID: 7636843
RAR_beta
ZINC01539546 agonist Compound 5 EC50 = 592 nM PMID: 7636843
ZINC01539579 agonist targretin Ki = 36 nM EC50 = 28 nM PMID: 10052980
RAR_gamma
ZINC01540632 agonist SR11237 EC50 = 34 nM PMID: 7650690
ZINC01543312 agonist SR11246 EC50 = 55 nM PMID: 7650690
ZINC01546069 agonist Compound 6b Ki = 4 nM EC50 = 5 nM Bioorg. Med. Chem. Lett., 1997, 7, 21, 2747
RXR_beta
ZINC01549276 antagonist Compound 11g Ki = 4 +/- 5 nM IC50 = 4 +/- 3 nM PMID: 12801232
ZINC01550918 agonist Compound 14 EC50 = 2700 nM PMID: 9733501
RAR_alpha
ZINC01891675 agonist Compound 7b Ki = 5 nM EC50 = 95 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC01892655 antagonist LG100754 Ki = 8 nM PMID: 8765503
ZINC01895566 agonist Compound 14b relative IC50 = 6.6 relative EC30 = 0.067 PMID: 9703470
RXR_beta
ZINC01997144 agonist Compound 18 Ki = 394 nM EC50 = 384 nM PMID: 10052980 RXR_gamma
ZINC02008474 agonist Compound 5a Kd = 2 nM EC50 = 13 nM PMID: 12482435
RAR_alpha
ZINC02568233 agonist Compound 5 EC50 = 2700 nM PMID: 8410972
RAR_alpha
ZINC03777578 agonist Compound 13 EC50 = 2800 nM PMID: 9733501
RAR_alpha
ZINC03818818 antagonist Compound 23a Ki = 7.8 +/- 1.2 nM IC50 = 6.8 +/- 2.3 nM PMID: 14592510
ZINC03834061 agonist Compound 3 Ki = 6 nM EC50 = 7 nM PMID: 10052980
RXR_beta
ZINC03834062 agonist Compound 9 Ki = 6 nM EC50 = 32 nM PMID: 10052980
RXR_beta
ZINC03834065 agonist Compound 14 Ki = 11 nM EC50 = 12 M PMID: 10052980
RXR_beta
ZINC03834066 agonist Compound 5 Ki = 12 nM EC50 = 27 nM PMID: 10052980
RXR_beta
ZINC03834068 agonist Compound 8 Ki = 26 nM EC50 = 5 nM PMID: 10052980
RXR_beta
ZINC03834070 agonist TTCNB Ki = 138 EC50 = 279 nM PMID: 10052980
RAR_gamma
ZINC03834071 agonist Compound 10 Ki = 177 nM EC50 = 86 nM PMID: 10052980
RXR_beta
ZINC03873121 agonist Compound 4 Ki = 18 +/- 1 nM EC50 = 11 +/- 10 nM PMID: 12801232
ZINC04474564 agonist docosahexaenoic acid EC50 = 5 – 10 µM PMID: 11118147 
ZINC04821771 agonist Compound 4 Ki = 9 nM EC50 = 5 nM PMID: 10052980
RXR_beta
ZINC04837700 antagonist Compound 11f Ki = 3 +/- 3 nM IC50 = 4 +/- 3 nM PMID: 12801232
ZINC04847295 antagonist Compound 4 Ki = 4.8 nM EC50 antago = 3.3 nM PMID: 12951091
ZINC05132309 agonist Compound 9 EC50 = 1100 nM PMID: 8410972
ZINC06070388 agonist Compound 2 EC50 = 385 nM PMID: 7636843
RAR_alpha
ZINC06845860 agonist oleic aCID EC50 = 5 – 10 µM PMID: 15073272
ZINC12358651 agonist ATRA Ki = 350 +/- 3.7 nM EC50 = 1084 +/- 33 nM PMID: 8709094
PPAR_gamma
ZINC12661824 agonist 9 cis-retinoic acid Kd = 15.7 nM EC50 = 100 +/- 25 nM PMID: 8380496 
RAR_alpha
ZINC13487075 agonist Compound 5b Kd = 16 nM EC50 = 31 nM PMID: 12482435 RXR_gamma
ZINC13487076 agonist Compound 8 Kd = 41 nM EC50 = 63 nM PMID: 12482435 RXR_gamma
ZINC13522221 agonist Compound 11a Ki = 1 +/- 2 nM EC50 = 2 +/- 1 nM PMID: 12801232
ZINC13522225 agonist Compound 11b Ki = 2 +/- 2 nM EC50 = 2 +/- 1 nM PMID: 12801232
ZINC13522229 antagonist Compound 11d Ki = 2 +/- 1 nM IC50 = 1 +/- 1 nM PMID: 12801232
ZINC13522234 antagonist Compound 11e Ki = 3 +/- 2 nM IC50 = 6 +/- 4 nM PMID: 12801232
ZINC13522239 antagonist Compound 6 Ki = 3.8 nM EC50_antago = 3.3 nM PMID: 12951091
ZINC13522243 agonist Compound 12a Ki = 1 +/- 1 nM EC50 = 36 +/- 15 nM PMID: 12801232
ZINC13522253 antagonist LG101506 Ki = 3 +/- 2 nM IC50 = 8 +/- 4 nM PMID: 15006411
ZINC13522257 antagonist Compound 12d Ki = 27 +/- 14 nM IC50 = 8 +/- 4 nM PMID: 12801232
ZINC13522262 antagonist Compound 12e Ki = 14 +/- 7 nM IC50 = 43 +/- 12 nM PMID: 12801232
ZINC13522268 agonist Compound 13a Ki = 2 +/- 1 nM EC50 = 506 +/- 50 nM PMID: 12801232
ZINC13522271 antagonist Compound 13b Ki = 2 +/- 1 nM IC50 = 17 +/- 5 nM PMID: 12801232
ZINC13522274 antagonist Compound 13c Ki = 29 +/- 5 nM IC50 = 16 +/- 10 nM PMID: 12801232
ZINC13522276 antagonist Compound 13d Ki = 23 +/- 6 nM IC50 = 13 +/- 2 nM PMID: 12801232
ZINC13560351 agonist Compound 20 Ki = 158 nM EC50 = 106 nM PMID: 15056000
ZINC13560369 agonist Compound 60 Ki = 90 nM EC50 = 97 nM PMID: 15056000
ZINC13587533 antagonist Compound 22 Ki = 4.4 +/- 2.1 nM IC50 = 4.7 +/- 1.6 nM PMID: 14592510
ZINC13587534 antagonist Compound 23b Ki = 4.1 +/- 2.4 nM IC50 = 7.2 +/- 2.5 nM PMID: 14592510
ZINC13587535 antagonist Compound 24 Ki = 28.7 +/- 1.3 nM IC50 = 13.7 +/- 3.0 nM PMID: 14592510
ZINC13587536 antagonist Compound 34a Ki = 2.3 +/- 1.5 nM IC50 = 3.1 +/- 1.0 nM PMID: 14592510
ZINC13587537 antagonist Compound 34b Ki = 1.0 +/- 0.2 nM IC50 = 3.9 +/- 1.1 nM PMID: 14592510
ZINC13587538 antagonist Compound 34c Ki = 0.8 +/- 0.2 nM IC50 = 1.9 +/- 0.5 nM PMID: 14592510
ZINC13587539 antagonist Compound 34d Ki = 2.6 +/- 1.2 nM IC50 = 4.6 +/- 1.5 nM PMID: 14592510
ZINC13587540 antagonist Compound 34e Ki = 3.0 +/- 1.3 nM IC50 = 3.6 +/- 1.5 nM PMID: 14592510
ZINC13587541 antagonist Compound 34f Ki = 0.8 +/- 0.3 nM IC50 = 2.2 +/- 1.2 nM PMID: 14592510
ZINC13587543 antagonist Compound 42b Ki = 25.6 +/- 15.2 nM IC50 = 5.1 +/- 2.2 nM PMID: 14592510
ZINC13587544 antagonist Compound 42c Ki = 21.4 +/- 12.3 nM IC50 = 4.0 +/- 1.2 nM PMID: 14592510
ZINC13587545 antagonist Compound 56 Ki = 6.1 +/- 4.2 nM IC50 = 57.9 +/- 8.3 nM PMID: 14592510
ZINC13587546 antagonist Compound 57 Ki = 85.8 +/- 18.3 nM IC50 = 10.7 +/- 6.4 nM PMID: 14592510
ZINC13648945 agonist Compound 7 Kd = 220 nM AC50 = 79 nM PMID: 12182871
ZINC13652278 agonist Compound 15 EC50 = 2600 nM PMID: 9733501
RAR_alpha
ZINC13734373 agonist 3-ethyl-TTNPB IC50 = 320 +/- 40 nM EC50 = 2900 +/- 250 nM PMID: 8308867 RAR_alpha
ZINC13734376 agonist 3-isopropyl-TTNPB IC50 = 320 +/- 65 nM EC50 = 300 +/- 32 nM PMID: 8308867 RXR_gamma
ZINC13738441 agonist Compound 5c Kd = 195 +/- 11 nM EC50 = 514 +/- 64 nM PMID: 8071941
ZINC13738442 agonist Compound 5d Kd = 113 +/- 13 nM EC50 = 381 +/- 16 nM PMID: 8071941
ZINC13738444 agonist Compound 5f Kd = 706 +/- 148 nM EC50 = 1820 nM PMID: 8071941
ZINC13738445 agonist Compound 5g Kd = 130 +/- 37 nM EC50 = 294 +/- 25 nM PMID: 8071941
ZINC13738446 agonist Compound 5h Kd = 105 +/- 7 nM EC50 = 332 nM PMID: 8071941
ZINC13738449 agonist Compound 12a Ki = 150 nM EC50 = 409 nM Bioorg. Med. Chem. Lett., 1997, 7, 21, 2747
RAR_alpha
ZINC13738450 agonist Compound 6c Kd = 31 +/- 8 nM EC50 = 115 nM PMID: 8071941
ZINC13738451 agonist Compound 6d Kd = 55 +/- 12 nM EC50 = 207 nM PMID: 8071941
ZINC13738453 agonist Compound 6f Kd = 69 +/- 21 nM EC50 = 197 nM PMID: 8071941
ZINC13738454 agonist Compound 6g Kd = 27 +/- 11 nM EC50 = 52 +/- 10 nM PMID: 8071941
ZINC13738455 agonist Compound 6h Kd = 28 +/- 3 nM EC50 = 51 +/- 6 nM PMID: 8071941
ZINC13738456 agonist Compound 6i Kd = 487 +/- 12 nM EC50 = 455 nM PMID: 8071941
ZINC13738457 agonist Compound 6j Kd = 96 +/- 46 nM EC50 = 83 nM PMID: 8071941
ZINC13739978 agonist (9Z)-UAB7 Kd = 33 +/- 5 nM IC50 = 620 nM PMID: 8809153
ZINC13741830 agonist (9Z)-UAB8 Kd = 16 +/- 0.6 nM IC50 = 1000 nM PMID: 8809153
ZINC13742306 agonist Compound 4 EC50 = 105 nM PMID: 7636843
RAR_alpha
ZINC13742307 agonist Compound 6 EC50 = 11 nM PMID: 7636843
RAR_beta
ZINC13742308 agonist Compound 8 EC50 = 112 nM PMID: 7636843 RAR_beta
ZINC13742674 agonist Compound 6b Kd = 1159 +/- 29 nM EC50 = 1200 nM PMID: 7636877
ZINC13742677 agonist Compound 6d Kd = 22 +/- 8 nM EC50 = 6 +/- 1 nM PMID: 7636877
ZINC13742678 agonist Compound 8b Kd = 50 nM EC50 = 300 nM PMID: 7636877
ZINC13742682 agonist Compound 12b Kd = 46 +/- 23 nM EC50 = 26 +/- 1 nM PMID: 7636877
ZINC13742685 agonist Compound 16b Kd = 520 nM EC50 = 1000 nM PMID: 7636877
ZINC13743076 agonist SR11332 EC50 = 55 nM PMID: 7650690
RAR_alpha
ZINC13743078 agonist SR11217 EC50 = 86 nM PMID: 7650690
ZINC13743081 agonist SR11236 EC50 = 750 nM PMID: 7650690
RAR_alpha
ZINC13743085 agonist SR11269 EC50 = 380 nM PMID: 7650690
RAR_alpha
ZINC13743086 agonist SR11268 EC50 = 200 nM PMID: 7650690 RAR_beta
ZINC13757372 agonist Compound 11 Ki = 2 nM EC50 = 5 nM PMID: 8765503
RXR_beta
ZINC13758053 agonist Compound 1 Kd = 3868 nM EC50 = 770 nM PMID: 8784454
RAR_beta
ZINC13758055 agonist Compound 2 Kd = 296 nM EC50 = 280 nM PMID: 8784454
RXR_beta
ZINC13758062 agonist Compound 4 Kd = 2518 nM EC50 = 2800 nM PMID: 8784454
RXR_beta
ZINC13758065 agonist Compound 5 Kd = 32 nM EC50 = 54 nM PMID: 8784454
RXR_beta
ZINC13775906 antagonist HX603 PMID: 19408900
ZINC13780871 agonist Compound 10 relative IC50 = 12.7 relative EC30 = 5.2 PMID: 9703470
RAR_alpha
ZINC13780872 agonist Compound 14a relative IC50 = 4.7 relative EC30 = 0.16 PMID: 9703470
RXR_beta
ZINC13780873 agonist Compound 14c relative IC50 = 9.0 relative EC30 = 0.68 PMID: 9703470
RXR_beta
ZINC13780874 agonist Compound 14d relative IC50 = 121 relative EC30 = 110 PMID: 9703470
RXR_beta
ZINC13781194 agonist Compound 10 EC50 = 2800 nM PMID: 9733501
RAR_alpha
ZINC13794324 agonist Compound 17 Ki = 60 nM EC50 = 46 nM PMID: 10052980
RXR_beta
ZINC13794339 agonist Compound 12 Ki = 7 nM EC50 = 6 nM PMID: 10052980
RXR_beta
ZINC13794342 agonist Compound 13 Ki = 21 nM EC50 = 116 nM PMID: 10052980
RXR_beta
ZINC13832720 agonist Compound 10 EC50 = 2800 nM PMID: 8410972
ZINC13832724 agonist Compound 14 EC50 = 1500 nM PMID: 8410972
RAR_alpha
ZINC13832727 agonist Compound 17 EC50 = 2800 nM PMID: 8410972
ZINC13911442 agonist Compound 6a Ki = 3 nM EC50 = 23 nM Bioorg. Med. Chem. Lett., 1997, 7, 21, 2747
RXR_beta
ZINC13973730 antagonist Compound 3 Ki = 7.8 nM EC50 antago = 3.4 nM PMID: 12951091
ZINC26403756 agonist Compound 16 Ki = 17 nM EC50 = 62 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC26403759 agonist Compound 9 Ki = 3 nM EC50 = 4 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC26466377 agonist Compound 17 Ki = 4 nM EC50 = 7 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC26467857 agonist Compound 6 Ki = 3 nM EC50 = 8 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC26469122 agonist Compound 14 Ki = 66 nM EC50 = 169 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC26476005 agonist Compound 7a Ki = 20 nM EC50 = 53 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC26486731 agonist Compound 15 Ki = 38 nM EC50 = 189 nM Bioorg. Med. Chem. Lett., 1997, 7, 18, 2393
ZINC26649488 agonist Compound 6 EC50 = 4 nM Bioorg. Med. Chem. Lett., 1995, 5, 22, 2729
RXR_beta
ZINC26653564 agonist Compound 8 EC50 = 59 nM Bioorg. Med. Chem. Lett., 1995, 5, 22, 2729
RXR_beta
ZINC26653569 agonist Compound 9 EC50 = 89 nM Bioorg. Med. Chem. Lett., 1995, 5, 22, 2729
RXR_beta
ZINC26653776 agonist Compound 5 EC50 = 2400 nM Bioorg. Med. Chem. Lett., 1995, 5, 22, 2729
RAR_alpha
ZINC26657237 agonist Compound 7 EC50 = 210 nM Bioorg. Med. Chem. Lett., 1995, 5, 22, 2729
RAR_alpha
ZINC26657257 agonist Compound 11a Ki = 92 nM EC50 = 51 nM Bioorg. Med. Chem. Lett., 1997, 7, 21, 2747
RXR_beta
ZINC26658609 antagonist Compound 11 Ki = 7.4 nM EC50 = 21.1 nM PMID: 15125928
ZINC26658839 antagonist Compound 1 Ki = 2.7 nM EC50 = 6.4 nM PMID: 15125928
ZINC26659220 antagonist Compound 12 Ki = 740.0 nM EC50 = 1533 nM PMID: 15125928
ZINC26661695 agonist Compound 8 Ki = 29.6 nM EC50 = 914 nM PMID: 15125928
ZINC26663009 antagonist Compound 13 Ki = 3.2 nM EC50 = 26.4 nM PMID: 15125928
ZINC26663021 antagonist Compound 14 Ki = 1.6 nM EC50 = 30.1 nM PMID: 15125928
ZINC26953150 antagonist Compound 7 Ki = 5208 nM EC50 antago = 805.8 PMID: 12951091
ZINC27072844 antagonist PA452 PMID: 12139443
ZINC27072854 agonist PA024 PMID: 21459577
ZINC28392739 antagonist BI-1003 Kd = 26 nM IC50 = 46 PMID: 19757405
ZINC28457271 antagonist BI-1005 Kd = 329 nM IC50 = 1200 PMID: 19757405
ZINC28458591 agonist Compound 9 PMID: 15317450
ZINC28459938 antagonist SR11179 Kd = 15 nM IC50 = 450 PMID: 19757405
ZINC28758393 agonist Compound 9 AC50 = 5 nM PMID: 10890152 RAR_beta
ZINC28758990 agonist Compound 10 IC50 = 21 nM PMID: 15317450
ZINC28760010 agonist Compound 4 AC50 = 135 nM PMID: 10890153 RAR_alpha
ZINC28760647 agonist Compound 5 AC50 = 430 nM PMID: 10890153
RAR_beta
ZINC28952149 agonist Compound 14a EC50 = 1.8 nM PMID: 17485209
ZINC28952154 agonist Compound 13 EC50 = 39.1 nM PMID: 17490875
ZINC28952165 agonist Compound 17 EC50 = 27.9 nM PMID: 17490875
ZINC28952171 agonist Compound 33 EC50 = 2.3 nM PMID: 17490875
ZINC28952173 agonist Compound 34 EC50 = 361 nM PMID: 17490875
ZINC28952178 agonist Compound 15b EC50 = 7.2 nM PMID: 17490875
ZINC28952180 agonist Compound 25 EC50 = 527 nM PMID: 17490875
ZINC28952251 agonist Compound 15a EC50 = 45.9 nM PMID: 17490875
ZINC28952252 agonist Compound 15c EC50 = 3.4 nM PMID: 17490875
ZINC28952256 agonist Compound 15d EC50 = 1.4 nM PMID: 17490875
ZINC28952260 agonist Compound 15e EC50 = 70.2 nM PMID: 17490875
ZINC28952261 agonist Compound 15f EC50 = 36.5 nM PMID: 17490875
ZINC28952263 agonist Compound 15g EC50 = 361 nM PMID: 17490875
ZINC28952281 agonist Compound 36 EC50 = 10 nM PMID: 17490875
ZINC28952475 agonist Compound 14d EC50 = 67.3 nM PMID: 17485209
ZINC28952493 agonist Compound 14f EC50 = 24.3 nM PMID: 17485209
ZINC28952494 agonist Compound 14g EC50 = 2.1 nM PMID: 17485209
ZINC28952496 agonist Compound 14h EC50 = 16.3 nM PMID: 17485209
ZINC28952497 agonist Compound 14i EC50 = 1.8 nM PMID: 17485209
ZINC28952504 agonist Compound 24 EC50 = 173.1 nM PMID: 17485209
ZINC28952509 agonist Compound 37 EC50 = 96.6 nM PMID: 17485209
ZINC29337432 antagonist Compound 59 Ki = 198 +/- 80 nM IC50 = 347 +/- 101 nM PMID: 15006411
ZINC29338322 antagonist Compound 35 Ki = 12 +/- 4 nM IC50 = 24 +/- 14 nM PMID: 15006411
ZINC29338326 antagonist Compound 37 Ki = 3 +/- 2 nM IC50 = 8 +/- 1 nM PMID: 15006411
ZINC29338668 antagonist Compound 38 Ki = 7 +/- 3 nM IC50 = 16 +/- 7 nM PMID: 15006411
ZINC29339034 antagonist Compound 66 Ki = 16 +/- 8 nM IC50 = 11 +/- 6 nM PMID: 15006411
ZINC29339038 antagonist Compound 67 Ki = 101 +/- 50 nM IC50 = 22 +/- 2 nM PMID: 15006411
ZINC29339432 antagonist Compound 36 Ki = 3 +/- 2 nM IC50 = 14 +/- 5 nM PMID: 15006411
ZINC29339441 antagonist Compound 34 Ki = 14 +/- 2 nM IC50 = 16 +/- 12 nM PMID: 15006411
ZINC29341729 antagonist Compound 61 Ki = 161 +/- 62 nM IC50 = 300 +/- 74 nM PMID: 15006411
ZINC29345012 antagonist Compound 58 Ki = 44 +/- 1 nM IC50 = 129 +/- 68 nM PMID: 15006411
ZINC29346737 antagonist Compound 60 Ki = 47 +/- 10 nM IC50 = 194 +/- 13 nM PMID: 15006411
ZINC34471674 agonist DA024 PMID: 21459577
ZINC36241968 antagonist Compound 39 Ki = 5 +/- 1 nM IC50 = 83 +/- 63 nM PMID: 15006411
ZINC36241986 agonist Compound 32 Ki = 644 nM EC50 = 1000 nM PMID: 16364638
RXR_beta
ZINC36241990 agonist Compound 34 Ki = 37 nM EC50 = 378 nM PMID: 16364638
RXR_beta
ZINC36241992 agonist Compound 35 Ki = 31 nM EC50 = 221 nM PMID: 16364638
RXR_beta
ZINC36241998 agonist Compound 49 Ki = 21 nM EC50 = 179 nM PMID: 16364638
RXR_beta
ZINC36242004 agonist Compound 43 Ki = 103 nM EC50 = 216 nM PMID: 16364638
RXR_beta
ZINC36242011 agonist Compound 36 Ki = 17 nM EC50 = 99 nM PMID: 16364638
RXR_beta
ZINC36766817 agonist Compound 12 Kd = 3 nM EC50 = 30 nM PMID: 12482435 RXR_gamma
ZINC37865786 agonist Compound 13 Kd = 6 nM EC50 = 34 nM PMID: 12482435 RXR_gamma
ZINC38563705 agonist Compound 1 J. Nat. Prod. 1994, 57, 10, 1458
ZINC3991534 agonist GW0791 Ki = 5 nM EC50 = 5 nM PMID: 15056000 
ZINC40423958 antagonist UVI3003 PMID: 17947383  RXR_beta
ZINC40846274 agonist Compound 5c PMID: 21489804
ZINC40896500 antagonist Compound 5g IC50 = 2.7 +/- 0.4 µM PMID: 19095448
RXR_beta
ZINC40896883 antagonist Compound 5h IC50 = 4.1 +/- 1.1 µM PMID: 19095448
RXR_beta
ZINC40933591 antagonist Compound 5f IC50 = 5.2 +/- 1.4 µM PMID: 19095448
RXR_beta
ZINC43014909 agonist Compound 35 EC50 = 0.576 µM PMID: 19216008
ZINC43059283 agonist Compound 34 EC50 = 0.60 µM PMID: 19216008
ZINC43074987 agonist Compound 24 EC50 = 1.137 µM PMID: 19216008
ZINC43204076 agonist Compound 5a EC50 = 66 +/- 9 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC44418529 antagonist Compound 5i IC50 = 3.2 +/- 1.1 µM PMID: 19095448
RXR_beta
ZINC45299198 agonist Compound 18 Ki = 161 +/- 28 nM EC50 = 420 +/- 63 nM PMID: 19791803
ZINC45321330 agonist Compound 20 Ki = 12 +/- 2 nM EC50 = 43 +/- 5 nM PMID: 19791803
ZINC45506076 antagonist UVI3006 PMID: 17947383 
ZINC53159698 agonist Compound 41 Ki = 63 nM EC50 = 123 nM PMID: 16364638
RXR_beta
ZINC53255787 agonist Compound 44 Ki = 42 nM EC50 = 64 nM PMID: 16364638
RXR_beta
ZINC53267943 agonist Compound 47 Ki = 257 nM EC50 = 400 nM PMID: 16364638 RXR_beta
ZINC53267949 agonist Compound 39 Ki = 21 nM EC50 = 53 nM PMID: 16364638
RXR_beta
ZINC53268017 agonist Compound 46 Ki = 18 nM EC50 = 231 nM PMID: 16364638
RXR_beta
ZINC53268020 agonist Compound 40 Ki = 67 nM EC50 = 252 nM PMID: 16364638
RXR_beta
ZINC53268030 agonist Compound 45 Ki = 47 nM EC50 = 152 nM PMID: 16364638
RXR_beta
ZINC53268224 agonist Compound 9 Ki = 8 nM EC50 = 22 nM PMID: 16364638
RXR_beta
ZINC58581582 agonist Compound 8d PMID: 20667726
ZINC58581812 agonist Compound 11 EC50 = 5.28 +/- 1.23 nM PMID: 20656484
ZINC58581987 agonist Compound 12 PMID: 20656484
ZINC58584095 agonist Compound 10 EC50 = 205 +/- 22 nM PMID: 20656484
ZINC59480982 agonist 3-methyl-TTNPB IC50 = 32 +/- 8.0 nM EC50 = 1200 +/- 120 nM PMID: 8308867
RAR_gamma
ZINC66102870 agonist Compound 5j EC50 = 280 +/- 150 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66104932 agonist Compound 5d EC50 = 110 +/- 20 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66111583 agonist Compound 5c EC50 = 290 +/- 40 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66111584 agonist Compound 5e EC50 = 160 +/- 80 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66112567 agonist Compound 5f EC50 = 160 +/- 30 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66112568 agonist Compound 5g EC50 = 450 +/- 80 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66112569 agonist Compound 5h EC50 = 180 +/- 30 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66112570 agonist Compound 5i EC50 = 160 +/ -20 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66112571 agonist Compound 5k EC50 = 160 +/- 60 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66112572 agonist Compound 5l EC50 = 330 +/- 120 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66114248 agonist Compound 5m EC50 = 820 +/- 110 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC66114297 agonist Compound 5b EC50 = 19 +/- 6 nM ACS Med. Chem. Lett., 2010, 1, 9, 521
ZINC71296637 agonist Compound 5e PMID: 21489804
ZINC71317138 agonist Compound 5b PMID: 21489804
ZINC71318233 agonist Compound 5d PMID: 21489804
ZINC71319086 agonist Compound 5f PMID: 21489804