Compound ID |
Pharmacological profile |
Compound name |
Binding data |
Activity data |
Bibliographic ref |
Cross-reactivity |
CHEMBL468608 |
agonist |
Compound 4 |
|
EC50 = 91 nM |
PMID: 19058965 |
RAR_beta |
ZINC00840991 |
agonist |
Compound 20b |
Relative IC50 = 27 +/- 4 |
Relative EC30 = 0.76 +/- 0.34 |
PMID: 10669568 |
RAR_alpha |
ZINC01483343 |
agonist |
Compound 16 |
|
EC50 = 152 nM |
PMID: 10543887 |
RAR_alpha |
ZINC01532939 |
agonist |
SR11004 |
|
EC50 = 1700 nM |
PMID: 7650690 |
|
ZINC01533168 |
agonist |
Compound 190121 |
Kd = 190 nM |
EC50 = 10 nM |
PMID: 11277515 |
|
ZINC01536828 |
agonist |
Compound 5d |
|
EC50 = 15 nM |
Bioorg. Med. Chem. Lett.1995,5,5,523 |
|
ZINC01539148 |
antagonist |
ER27191 |
IC50 = 0.34 nM |
IC50 = 4.9 nM |
PMID: 7636879 |
RAR_alpha |
ZINC01539149 |
antagonist |
Compound 55 |
IC50 = 0.91 nM |
IC50 = 1.3 nM |
PMID: 7636879 |
RAR_alpha |
ZINC01539150 |
antagonist |
Compound 40 |
IC50 = 0.16 nM |
IC50 = 5.6 nM |
PMID: 7636879 |
RAR_alpha |
ZINC01539151 |
antagonist |
Compound 4 |
IC50 = 16 nM |
IC50 = 0.12 µM |
PMID: 7636879 |
RAR_alpha |
ZINC01539543 |
agonist |
Compound 3 |
|
EC50 = 979 nM |
Bioorg. Med. Chem. Lett.1995,5,22,2729 |
|
ZINC01539579 |
agonist |
SR11247 |
|
EC50 = 122 nM |
PMID: 7650690 |
|
ZINC01540058 |
agonist |
Compound 8 |
|
EC50 = 10 nM |
PMID: 19058965 |
RAR_beta |
ZINC01542199 |
agonist |
Tazarotene |
|
EC50 = 40 nM |
PMID: 19058965 |
|
ZINC01543482 |
antagonist |
AGN193109 |
Kd = 7 +/- 1 |
IC50 = 5 +/- 1 |
PMID: 8798442 |
RAR_alpha |
ZINC01550918 |
agonist |
Compound 14 |
|
EC50 = 12 nM |
PMID: 9733501 |
|
ZINC01891052 |
agonist |
LG100567 |
Ki = 124 +/- 18 nM |
EC50 = 16 +/- 1.0
nM |
PMID: 8709094 |
|
ZINC01891456 |
agonist |
Compound 37 |
|
EC50 ratio = 8 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC01891459 |
agonist |
Compound 33 |
|
EC50 ratio = 2 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC01895357 |
antagonist |
Compound 5 |
Kd = 10618 +/- 3688 nM |
|
PMID: 9258350 |
|
ZINC01895361 |
antagonist |
Compound 1 |
Kd =3121 +/- 1457 nM |
|
PMID: 9258350 |
|
ZINC01895365 |
antagonist |
Compound 2 |
Kd = 863 +/- 138 nM |
|
PMID: 9258350 |
|
ZINC01895370 |
antagonist |
Compound 4 |
Kd = 7258 +/- 2648 nM |
|
PMID: 9258350 |
|
ZINC01896358 |
antagonist |
Compound 2b |
Kd = 33 nM |
IC50 = 4 nM |
PMID: 10201840 |
|
ZINC01996688 |
antagonist |
Compound 3a |
Kd = 5 nM |
IC50 = 0.5 nM |
PMID: 10201840 |
|
ZINC02008474 |
agonist |
Compound 5a |
Kd = 552 nM |
EC50 = 24 nM |
PMID: 12482435 |
|
ZINC02046792 |
agonist |
BMS961 |
|
|
PMID: 9501913 |
|
ZINC02568233 |
agonist |
TTNPB |
IC50 = 26 +/- 4.3 nM |
EC50 = 2 +/- 1 nM |
PMID: 7791761 |
|
ZINC03777578 |
agonist |
Compound 13 |
|
EC50 = 39 nM |
PMID: 9733501 |
|
ZINC03784077 |
agonist |
Am580 |
Kd = 3800 nM |
EC50 = 19 nM |
PMID: 12372520 |
RAR_alpha |
ZINC03784182 |
agonist |
adapalene |
Ki = 130 +/- 25 nM |
AC50 = 37 +/- 7 nM |
PMID: 8544175 |
RAR_alpha |
ZINC03834070 |
agonist |
SR11225 |
|
EC50 = 1200 nM |
PMID: 7650690 |
|
ZINC03871916 |
agonist |
Compound 1 |
|
EC50 ratio = 1.4 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
|
ZINC03936873 |
agonist |
CD437 |
|
|
PMID: 9929154 |
RAR_alpha |
ZINC03951146 |
agonist |
ER-34617 |
Relative IC50 = 310 +/- 40 |
Relative EC30 = 20 +/- 6 |
PMID: 10669568 |
|
ZINC03952051 |
agonist |
MX3350-1 |
|
|
PMID: 19216008 |
|
ZINC04475360 |
agonist |
Compound 1 |
|
EC50 = 2.4 nM |
PMID: 7636843 |
|
ZINC04825704 |
agonist |
ALRT1550 |
Ki = 1.9 +/- 0.2 nM |
EC50 = 0.34 +/- 0.04 nM |
PMID: 8709094 |
|
ZINC05762247 |
agonist |
CD2019 |
Ki = 160 +/- 23 nM |
AC50 = 150 +/- 21
nM |
PMID: 8544175 |
|
ZINC06070388 |
agonist |
3-methyl-TTNPB |
IC50 = 645 +/- 120 nM |
EC50 = 180 +/- 15
nM |
PMID: 8308867 |
|
ZINC06394310 |
agonist |
BMS184394 |
Kd = 816 nM |
|
PMID: 8691435 |
RAR_beta |
ZINC12358651 |
agonist |
All-trans-retinoic acid |
IC50 = 18 +/- 1.8 nM |
EC50 = 10 +/- 2 nM |
PMID: 7791761 |
|
ZINC12661824 |
agonist |
9-cis-retinoic acid |
IC50 = 17 +/- 1.1 nM |
EC50 =45 +/- 5 nM |
PMID: 7791761 |
RAR_alpha |
ZINC13649044 |
agonist |
AGN 193312 |
Kd = 990 nM |
EC50 = 350 nM |
PMID: 12372520 |
|
ZINC13652275 |
agonist |
Compound 18 |
|
EC50 = 30 nM |
PMID: 9733501 |
RAR_alpha |
ZINC13652278 |
agonist |
Compound 15 |
|
EC50 = 8 nM |
PMID: 9733501 |
|
ZINC13652279 |
agonist |
Compound 17 |
|
EC50 = 460 nM |
PMID: 9733501 |
RAR_alpha |
ZINC13652284 |
agonist |
Compound 16 |
|
EC50 = 200 nM |
PMID: 9733501 |
RAR_alpha |
ZINC13676272 |
agonist |
Compound 28 |
|
PEC50 = 6.3 +/- 0.6 |
PMID: 19239230 |
|
ZINC13734373 |
agonist |
3-ethyl-TTNPB |
IC50 = 250 +/- 38 nM |
EC50 = 23 +/- 4 nM |
PMID: 8308867 |
|
ZINC13734849 |
agonist |
Compound 12a |
Ki = 887 nM |
EC50 = 266 nM |
Bioorg. Med. Chem. Lett.1997,7,21,2747 |
RAR_beta |
ZINC13738449 |
agonist |
SR11201 |
|
EC50 = 3000 nM |
PMID: 7650690 |
|
ZINC13742306 |
agonist |
Compound 4 |
|
EC50 = 374 nM |
PMID: 7636843 |
|
ZINC13742307 |
agonist |
Compound 4 |
|
EC50 = 131 nM |
Bioorg. Med. Chem. Lett.1995,5,22,2729 |
|
ZINC13742673 |
agonist |
Compound 2 |
Ki = 3206 nM |
EC50 = 648 nM |
PMID: 10052980 |
RAR_beta |
ZINC13742689 |
antagonist |
Compound 3 |
IC50 = 17 nM |
IC50 = 0.5 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742692 |
antagonist |
Compound 26 |
IC50 = 14 nM |
IC50 = 0.36 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742693 |
antagonist |
Compound 27 |
IC50 = 19 nM |
IC50 = 0.52 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742694 |
antagonist |
Compound 29 |
IC50 = 1.2 nM |
IC50 = 0.21 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742695 |
antagonist |
Compound 30 |
IC50 = 0.59 nM |
IC50 = 33 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742696 |
antagonist |
Compound 32 |
IC50 = 2.3 nM |
IC50 = 84 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742697 |
antagonist |
Compound 33 |
IC50 = 0.14 nM |
IC50 = 17 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742698 |
antagonist |
Compound 34 |
IC50 = 16 nM |
IC50 = 1.3 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742699 |
antagonist |
Compound 35 |
IC50 = 5.6 nM |
IC50 = 0.65 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742700 |
antagonist |
Compound 36 |
IC50 = 3.2 nM |
IC50 = 0.49 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742701 |
antagonist |
Compound 37 |
IC50 = 3.4 nM |
IC50 = 51 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742702 |
antagonist |
Compound 38 |
IC50 = 4.5 nM |
IC50 = 0.54 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742703 |
antagonist |
Compound 54 |
IC50 = 1.5 nM |
IC50 = 56 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742704 |
antagonist |
Compound 39 |
IC50 = 19 nM |
IC50 = 0.1 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742705 |
antagonist |
Compound 42 |
IC50 = 4.7 nM |
IC50 = 78 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742706 |
antagonist |
Compound 51 |
IC50 = 11 nM |
IC50 = 77 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742707 |
antagonist |
Compound 43 |
IC50 = 13 nM |
IC50 = 1.1 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742708 |
antagonist |
Compound 45 |
IC50 = 0.97 nM |
IC50 = 69 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742709 |
antagonist |
Compound 46 |
IC50 = 22 nM |
IC50 = 0.17 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742710 |
antagonist |
Compound 47 |
IC50 = 3.7 nM |
IC50 = 37 nM |
PMID: 7636879 |
RAR_alpha |
ZINC13742711 |
antagonist |
Compound 48 |
IC50 = 2.9 nM |
IC50 = 0.23 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13742712 |
antagonist |
Compound 49 |
IC50 = 30 nM |
IC50 = 0.3 µM |
PMID: 7636879 |
RAR_alpha |
ZINC13743071 |
agonist |
SR11215 |
|
EC50 = 530 nM |
PMID: 7650690 |
RAR_beta |
ZINC13743072 |
agonist |
SR11224 |
|
EC50 = 2000 nM |
PMID: 7650690 |
RAR_beta |
ZINC13743075 |
agonist |
SR11255 |
|
EC50 = 2300 nM |
PMID: 7650690 |
RAR_beta |
ZINC13743076 |
agonist |
SR11332 |
|
EC50 = 370 nM |
PMID: 7650690 |
|
ZINC13743081 |
agonist |
SR11236 |
|
EC50 = 1200 NM |
PMID: 7650690 |
|
ZINC13743082 |
agonist |
SR11203 |
|
EC50 = 540 nM |
PMID: 7650690 |
RAR_alpha |
ZINC13743083 |
agonist |
SR11245 |
|
EC50 = 300 nM |
PMID: 7650690 |
|
ZINC13743084 |
agonist |
SR11251 |
|
EC50 = 520 nM |
PMID: 7650690 |
|
ZINC13743085 |
agonist |
SR11269 |
|
EC50 = 650 nM |
PMID: 7650690 |
|
ZINC13743087 |
agonist |
SR11249 |
|
EC50 = 2300 nM |
PMID: 7650690 |
|
ZINC13745041 |
agonist |
Compound 1 |
Ki = 426 +/- 16 nM |
AC50 = 200 +/- 80 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13745045 |
agonist |
Compound 4 |
Ki = 121 +/- 6 nM |
AC50 = 175 +/- 25 nM |
PMID: 8544175 |
|
ZINC13745047 |
agonist |
MX2870-1 |
|
|
PMID: 14576769
|
|
ZINC13745049 |
agonist |
Compound 9 |
Ki = 72 +/- 2 nM |
AC50 = 7.5 +/- 4 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13745051 |
agonist |
Compound 10 |
Ki = 153 +/- 27 nM |
AC50 = 73 +/- 70 nM |
PMID: 8544175 |
|
ZINC13745055 |
agonist |
Compound 11 |
Ki = 34 +/- 5 nM |
AC50 = 100 +/- 39 nM |
PMID: 8544175 |
|
ZINC13745061 |
agonist |
Compound 12 |
Ki = 151 +/- 45 nM |
AC50 = 83 +/- 28 nM |
PMID: 8544175 |
|
ZINC13745065 |
agonist |
Compound 14 |
Ki = 13 +/- 2.5 nM |
AC50 = 30 +/- 5 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13745067 |
antagonist |
Compound 15 |
Ki = 85 +/- 10 nM |
IC50 = 700 +/- 125 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13745069 |
agonist |
Compound 16 |
Ki = 29 +/- 15 nM |
AC50 = 30 +/- 16 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13745071 |
agonist |
Compound 17 |
Ki = 27 +/- 12 nM |
AC50 = 300 +/- 60 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13745073 |
agonist |
Compound 20 |
Ki = 20 +/- 6 nM |
AC50 = 1 +/- 0.41 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13745075 |
agonist |
CD2325 |
Ki = 53 +/- 7 nM |
AC50 = 66 +/- 24 nM |
PMID: 8544175 |
RAR_alpha |
ZINC13775908 |
antagonist |
LE-540 |
Ki = 490 nM |
IC50 = 0.36 nM |
PMID: 9435893 |
|
ZINC13780871 |
agonist |
Compound 10 |
relative IC50 = 187 |
relative EC30 = 25 |
PMID: 9703470 |
|
ZINC13781194 |
agonist |
Compound 10 |
|
EC50 = 230 nM |
PMID: 9733501 |
|
ZINC13781195 |
agonist |
Compound 12 |
|
EC50 = 84 nM |
PMID: 9733501 |
RAR_alpha |
ZINC13781196 |
agonist |
Compound 19 |
|
EC50 = 330 nM |
PMID: 9733501 |
RAR_alpha |
ZINC13781197 |
agonist |
Compound 20 |
|
EC50 = 400 nM |
PMID: 9733501 |
|
ZINC13800362 |
agonist |
Compound 2 |
|
EC50 = 6 nM |
PMID: 10479291 |
RAR_alpha |
ZINC13804910 |
agonist |
Compound 2 |
Relative IC50 = 21 +/- 5 |
Relative EC30 = 3.5 +/- 0.5 |
PMID: 10669568 |
|
ZINC13804913 |
agonist |
Compound 20a |
Relative IC50 = 150 +/- |
Relative EC30 = 1.6 +/- 0.3 |
PMID: 10669568 |
|
ZINC13804918 |
agonist |
Compound 3b |
Relative IC50 = 4.6 +/- 0.9 |
Relative EC30 = 1.5 +/- 0.4 |
PMID: 10669568 |
RAR_alpha |
ZINC13804921 |
agonist |
Compound 3c |
Relative IC50 = 17 +/- 4 |
Relative EC30 = 2.1 +/- 0.5 |
PMID: 10669568 |
RAR_alpha |
ZINC13804924 |
agonist |
Compound 20c |
Relative IC50 = 2.0 +/- 0.5 |
Relative EC30 = 0.72 +/- 0.18 |
PMID: 10669568 |
RAR_alpha |
ZINC13804926 |
agonist |
Compound 27 b |
Relative IC50 = 3.6 +/- 0.7 |
Relative EC30 = 0.34 +/- 0.03 |
PMID: 10669568 |
RAR_alpha |
ZINC13815202 |
agonist |
Compound 4 |
|
EC50 ratio = 67 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
RAR_beta |
ZINC13815342 |
agonist |
Compound 36 |
|
EC50 ratio = 15 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
|
ZINC13815366 |
agonist |
Compound II |
Ki = 19 nM |
AC50 = 58 nM |
Bioorg. Med. Chem. Lett.1997,7,17,2289 |
RAR_alpha |
ZINC13815373 |
agonist |
Compound VII |
Ki = 1036 nM |
AC50 = 300 nM |
Bioorg. Med. Chem. Lett.1997,7,17,2289 |
RAR_alpha |
ZINC13815441 |
agonist |
Cp 18 |
Ki = 95 +/- 15 nM |
AC50 = 100 +/- 29 nM |
PMID: 8544175 |
|
ZINC13815522 |
agonist |
Compound IV |
Ki = 148 nM |
AC50 = 148 nM |
Bioorg. Med. Chem. Lett.1997,7,17,2289 |
RAR_alpha |
ZINC13815525 |
agonist |
Compound VI |
Ki = 531 nM |
AC50 = 305 nM |
Bioorg. Med. Chem. Lett.1997,7,17,2289 |
|
ZINC26385838 |
agonist |
Compound III |
Ki = 174 nM |
AC50 = 34 nM |
Bioorg. Med. Chem. Lett.1997,7,17,2289 |
RAR_alpha |
ZINC26404440 |
agonist |
Compound 5 |
Kd = 17 nM |
EC50 = 4 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
RAR_beta |
ZINC26404528 |
agonist |
Compound 9 |
Kd = 52 nM |
EC50 = 3 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
|
ZINC26468527 |
agonist |
Compound 6 |
Kd = 233 nM |
EC50 = 54 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
RAR_beta |
ZINC26472010 |
agonist |
Compound 7 |
Kd = 52 nM |
EC50 = 3 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
|
ZINC26475061 |
agonist |
Compound 1 |
Kd = 2421 nM |
EC50 = 130 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
|
ZINC26475560 |
agonist |
Compound 3 |
Kd = 72 nM |
EC50 = 6 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
RAR_beta |
ZINC26649488 |
agonist |
Compound 6 |
|
EC50 = 200 nM |
Bioorg. Med. Chem. Lett.1995,5,22,2729 |
|
ZINC26653776 |
agonist |
Compound 5 |
|
EC50 = 15 nM |
Bioorg. Med. Chem. Lett.1995,5,22,2729 |
|
ZINC26657237 |
agonist |
Compound 7 |
|
EC50 = 34 nM |
Bioorg. Med. Chem. Lett.1995,5,22,2729 |
|
ZINC26720801 |
agonist |
Compound 34 |
|
EC50 ratio = 100 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
RAR_beta |
ZINC26721478 |
agonist |
Compound 8 |
|
EC50 ratio = 6 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26722733 |
agonist |
Compound 11 |
|
EC50 ratio = 10 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
RAR_beta |
ZINC26722746 |
agonist |
Compound 14 |
|
EC50 ratio = 5.6 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
RAR_beta |
ZINC26723573 |
agonist |
Compound 3 |
|
EC50 ratio = 15 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26723692 |
agonist |
CD666 |
Kd = 68 nM |
AC50 = 1.4 nM |
PMID: 1323296 |
|
ZINC26723802 |
agonist |
Compound 12 |
|
EC50 ratio = 15 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
RAR_beta |
ZINC26725973 |
agonist |
Compound 5 |
|
EC50 ratio = 20 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26726175 |
agonist |
Compound 40 |
|
EC50 ratio = 150 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
RAR_beta |
ZINC26726186 |
agonist |
Compound 39 |
|
EC50 ratio = 8 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26726205 |
agonist |
Compound 38 |
|
EC50 ratio = 0.2 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26726337 |
agonist |
Compound 35 |
|
EC50 ratio = 100 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
RAR_beta |
ZINC26728419 |
agonist |
Compound 6 |
|
EC50 ratio = 75 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26728536 |
agonist |
Compound 13 |
|
EC50 ratio = 30 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26729112 |
agonist |
Compound 8 |
|
EC50 ratio = 17 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
RAR_beta |
ZINC26730594 |
agonist |
Compound 10 |
|
EC50 ratio = 1 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
|
ZINC26730599 |
agonist |
Compound 6 |
|
EC50 ratio = 167 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
|
ZINC26731406 |
agonist |
Compound 15 |
|
EC50 ratio = 100 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
RAR_beta |
ZINC26731440 |
agonist |
Compound 12 |
|
EC50 ratio = 20 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
RAR_beta |
ZINC26731806 |
agonist |
Compound 9 |
|
EC50 ratio = 17 |
Bioorg. Med. Chem. Lett.1996,6,23,2859 |
RAR_beta |
ZINC26731821 |
agonist |
Compound 7 |
|
EC50 ratio = 3 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26731825 |
agonist |
Compound 9 |
|
EC50 ratio = 6.7 |
Bioorg. Med. Chem. Lett.1996,6,23,2865 |
|
ZINC26850547 |
agonist |
Compound 2 |
IC50 = 19 nM |
ED1/3 = 90 nM |
PMID: 7636879 |
RAR_alpha |
ZINC27564375 |
agonist |
Compound 10 |
|
EC50 = 930 nM |
Bioorg. Med. Chem. Lett.1995,5,5,523 |
|
ZINC27638789 |
antagonist |
Compound 19 |
Kd = 36 +/- 7 nM |
|
PMID: 10098666 |
|
ZINC27645098 |
antagonist |
Compound 18 |
Kd = 99 +/- 24 nM |
|
PMID: 10098666 |
|
ZINC27645104 |
antagonist |
Compound 17 |
Kd = 254 +/- 118 nM |
|
PMID: 10098666 |
|
ZINC27646410 |
antagonist |
Compound 14 |
Kd = 82 +/- 35 nM |
|
PMID: 10098666 |
|
ZINC27646416 |
antagonist |
Compound 13 |
Kd = 94 +/- 63 nM |
|
PMID: 10098666 |
|
ZINC27647311 |
antagonist |
Compound 8 |
Kd = 35 +/- 9 nM |
|
PMID: 10098666 |
|
ZINC27647825 |
antagonist |
Compound 7 |
Kd = 42 +/- 9 nM |
|
PMID: 10098666 |
|
ZINC27648652 |
antagonist |
Compound 16 |
Kd = 57 +/- 28 nM |
|
PMID: 10098666 |
|
ZINC27648730 |
antagonist |
Compound 20 |
Kd = 51 +/- 15 nM |
|
PMID: 10098666 |
|
ZINC27650406 |
antagonist |
Compound 15 |
Kd = 27 +/- 8 nM |
|
PMID: 10098666 |
|
ZINC27651543 |
antagonist |
Compound 9 |
Kd = 67 +/- 30 nM |
|
PMID: 10098666 |
|
ZINC27652518 |
antagonist |
Compound 12 |
Kd = 171 +/- 51 nM |
|
PMID: 10098666 |
|
ZINC27652522 |
antagonist |
Compound 11 |
Kd = 19 +/- 8 nM |
|
PMID: 10098666 |
|
ZINC27652526 |
antagonist |
Compound 10 |
Kd =408 +/- 146 nM |
|
PMID: 10098666 |
|
ZINC27720272 |
agonist |
Compound 11c |
Relative IC50 = 70 |
Relative EC30 = 2.3 |
PMID: 10762038 |
|
ZINC27847873 |
antagonist |
Compound 2a |
Kd = 14 nM |
IC50 = 2 nM |
PMID: 10201840 |
|
ZINC27858089 |
antagonist |
Compound 1a |
Kd = 7 nM |
IC50 = 2 nM |
PMID: 10201840 |
|
ZINC27866591 |
antagonist |
Compound 1b |
Kd = 11 nM |
IC50 = 2 nM |
PMID: 10201840 |
|
ZINC28227159 |
agonist |
Compound 12b |
Relative IC50 = 251 |
ED30 = 100 nM |
PMID: 11354380 |
|
ZINC28227625 |
agonist |
Compound 12d |
Relative IC50 = 141 |
ED30 = 100 nM |
PMID: 11354380 |
|
ZINC28227633 |
antagonist |
Compound 12e |
Relative IC50 = 22 |
IC50 = 17 nM |
PMID: 11354380 |
|
ZINC28227892 |
antagonist |
Compound 12c |
Relative IC50 = 834 |
IC50 = 1.6 nM |
PMID: 11354380 |
|
ZINC28228318 |
antagonist |
Compound 12f |
Relative IC50 = 432 |
IC50 = 6.4 nM |
PMID: 11354380 |
|
ZINC28648307 |
agonist |
Compound 7 |
Ki = 77 +/- 18 nM |
AC50 = 33 +/- 27 nM |
PMID: 8544175 |
|
ZINC28758554 |
agonist |
Compound 3 |
|
AC50 = 2.3 nM |
PMID: 10890153 |
|
ZINC28759623 |
agonist |
Compound 7 |
|
AC50 = 1000 nM |
PMID: 10890153 |
|
ZINC28760483 |
agonist |
Compound 8 |
|
AC50 = 220 nM |
PMID: 10890153 |
RAR_beta |
ZINC28760647 |
agonist |
Compound 5 |
|
AC50 = 1.0 nM |
PMID: 10890153 |
|
ZINC31597129 |
antagonist |
CD2665 |
|
|
PMID: 11072095 |
|
ZINC34023910 |
antagonist |
BMS493 |
|
|
PMID: 19670208 |
RAR_beta |
ZINC34807014 |
agonist |
Compound 26 |
|
PEC50 = 6.2 +/- 0.3 |
PMID: 19239230 |
RAR_beta |
ZINC38467831 |
agonist |
palovarotene |
|
|
PMID: 19876792 |
|
ZINC38493164 |
agonist |
Compound 9 |
|
EC50 = 0.6 nM |
PMID: 19058965 |
|
ZINC42891672 |
agonist |
Compound 8 |
|
PEC50 = 6.8 |
PMID: 19239230 |
|
ZINC59480982 |
agonist |
Compound 2 |
|
EC50 = 152 nM |
PMID: 7636843 |
|
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