Compound ID Pharmacological profile Compound name Binding data Activity data Bibliographic ref Cross-reactivity
CHEMBL468608 agonist Compound 4 EC50 = 26 nM PMID: 19058965 RAR_gamma
CHEMBL511855 agonist Compound 5 EC50 = 820 nM PMID: 19058965
CID10068598 agonist LE-511 PMID: 10336422 
CID10410894 antagonist LE-135 Ki = 0.22 µM PMID: 10336422 
CID10458226 antagonist LE-540 PMID: 10336422 
CID216241 antagonist CD2665 Kd=306 nM PMID: 10651997
CID22737393 agonist BMS641 Kd = 2.5 nM PMID: 15319780
CID60164 agonist adapalene Kd=34 nM AC50=40 nM PMID: 10651997
ZINC00006827 agonist Compound 11b Relative IC50 = 660 Relative EC30 = 1.8 PMID: 10762038 RAR_alpha
ZINC00007543 agonist Compound 1b Relative IC50 = 490 +/- 60 Relative EC30 = 25 +/- 12 PMID: 10956201 RAR_alpha
ZINC00583260 agonist Compound 1f Relative IC50 =500 +/- 50 Relative EC30 = 8.5 +/- 0.4 PMID: 10956201 RAR_alpha
ZINC00839593 agonist Compound 3 Kd = 189 +/- 41 nM EC50 = 26 +/- 2 nM PMID: 8978832
ZINC01532939 agonist SR11004 EC50 = 3200 nM PMID: 7650690 
RAR_alpha
ZINC01533168 agonist Compound 190121 Kd = 20 nM EC50 = 7 nM PMID: 11277515
RAR_alpha
ZINC01539543 agonist Compound 3 EC50 = 1990 nM Bioorg. Med. Chem. Lett.1995,5,22,2729
RAR_gamma
ZINC01540058 agonist Compound 8 EC50 = 10 nM PMID: 19058965 RAR_gamma
ZINC01542199 agonist Tazarotene EC50 = 0.8 nM PMID: 19058965
RAR_alpha
ZINC01891052 agonist LG100567 Ki = 90.4 +/- 9.0 nM EC50 =24 +/- 3.0 nM PMID: 8709094
RAR_alpha
ZINC01891456 agonist Compound 37 EC50 ratio = 20 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC01891459 agonist Compound 33 EC50 ratio = 10 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC01891905 agonist AGN193835 Kd = 3037 +/- 859 nM PMID: 8759622 RAR_alpha
ZINC01895357 antagonist Compound 5 Kd =898 +/- 362 nM PMID: 9258350
RAR_alpha
ZINC01895361 antagonist Compound 1 Kd = 1020 +/- 316 nM PMID: 9258350
RAR_alpha
ZINC01895365 antagonist Compound 2 Kd = 622 +/- 185 nM PMID: 9258350
RAR_alpha
ZINC01895368 antagonist Compound 3 Kd =2256 +/- 1257 nM PMID: 9258350 RAR_alpha
ZINC01895370 antagonist Compound 4 Kd = 320 +/- 87 nM PMID: 9258350
RAR_alpha
ZINC01896358 antagonist Compound 2b Kd = 12 nM IC50 = 6.5 nM PMID: 10201840 RAR_alpha
ZINC01996688 antagonist Compound 3a Kd = 6 nM IC50 = 2 nM PMID: 10201840 RAR_alpha
ZINC02008474 agonist Compound 5a Kd = 463 nM EC50 = 17 nM PMID: 12482435 RAR_alpha
ZINC02030426 agonist Compound 3 pEC50 = 6.9 +/ - 0.4 PMID: 19239230 RAR_alpha
ZINC02512493 agonist Compound 4 pEC50 = 7.6 +/- 0.3 PMID: 19239230
ZINC02512494 agonist Compound 1e pEC50 = 7.3 +/- 0.5 PMID: 16302793
ZINC02557057 agonist Compound 20 PEC50 = 7.0 +/- 0.2 PMID: 19239230
ZINC02559374 agonist Compound 1c pEC50 = 7.2 +/- 0.6 PMID: 16302793
ZINC02559375 agonist Compound 1d pEC50 = 7.8 +/- 0.2 PMID: 16302793
ZINC02566763 agonist Compound 14 PEC50 = 7.5 +/- 1.0 PMID: 19239230
ZINC02568233 agonist TTNPB IC50 = 5 +/- 2.3 EC50 = 3 +/- 2 nM PMID: 7791761
RAR_alpha
ZINC02569866 agonist Compound 19 PEC50 = 7.2 +/- 0.3 PMID: 19239230
ZINC03014539 agonist Compound 1h pEC50 = 7.8 +/- 0.4 PMID: 16302793
ZINC03871916 agonist CD564 Kd = 1.2 nM PMID: 10964567 
RAR_alpha
ZINC03951146 agonist ER-34617 Relative IC50 = 230 +/- 120 Relative EC30 = 2.5 +/- 0.3 PMID: 10669568 RAR_alpha
ZINC04475360 agonist Compound 3 EC50 = 6 nM PMID: 8410972 RAR_alpha
ZINC04825619 agonist Compound 6 AC50 = 2 nM PMID: 10890152
ZINC04825704 agonist ALRT1550 Ki = 0.7 +/- 0.3 nM EC50 = 2.2 +/- 0.7 nM PMID: 8709094
RAR_alpha
ZINC05132292 agonist Compound 6 EC50 = 250 nM PMID: 8410972
ZINC05355080 agonist Ch 55 PMID: 11769677
ZINC05762192 agonist BMS181156 Kd = 3.5 µM PMID: 10964567  RAR_alpha
ZINC05762247 agonist CD2019 Ki = 26 +/- 5 nM AC50 = 150 +/- 21  nM PMID: 8544175 
RAR_alpha
ZINC06070388 agonist 3-methyl-TTNPB IC50 = 1169 +/- 274 nM EC50 = 230 +/- 28  nM PMID: 8308867 RAR_alpha
ZINC06394310 agonist Compound 2 EC50 ratio = 133 Bioorg. Med. Chem. Lett. 1996,6,23,2859 RAR_gamma
ZINC12358651 agonist All-trans-retinoic acid IC50 50 = 13 +/- 3 nM EC50 = 80 +/- 9 nM PMID: 7791761
PPAR_gamma
ZINC12661824 agonist 9-cis-retinoic acid IC50 = 7 +/- 1.3 nM EC50 = 50 +/- 17 nM PMID: 7791761
RAR_alpha
ZINC13649044 agonist AGN193312 Kd = 380 nM EC50 = 45 nM PMID: 12372520
RAR_alpha
ZINC13676272 agonist Ac 261066 PEC50 = 8.1 +/- 0.4 PMID: 19239230 RAR_alpha
ZINC13734373 agonist 3-ethyl-TTNPB IC50 = 75 +/- 20 nM EC50 = 310 +/- 29 nM PMID: 8308867 RAR_alpha
ZINC13734849 agonist Compound 12a Ki = 909 nM EC50 = 304 nM Bioorg. Med. Chem. Lett. 1997, 7,21, 2747 RAR_gamma
ZINC13738449 agonist SR11201 EC50 = 320 nM PMID: 7650690 
RAR_alpha
ZINC13742306 agonist Compound 4 EC50 = 21 nM PMID: 7636843
RAR_alpha
ZINC13742307 agonist Compound 4 EC50 = 56 nM Bioorg. Med. Chem. Lett.1995,5,22,2729 RAR_gamma
ZINC13742308 agonist Compound 8 EC50 = 1080 nM PMID: 7636843 RXR_alpha
ZINC13742673 agonist Compound 2 Ki = 5353 nM EC50 = 282 nM PMID: 10052980 RAR_gamma
ZINC13743071 agonist SR11215 EC50 = 1900 nM PMID: 7650690  RAR_gamma
ZINC13743072 agonist SR11224 EC50 = 2700 nM PMID: 7650690  RAR_gamma
ZINC13743073 agonist SR11223 EC50 = 500 nM PMID: 7650690 
ZINC13743075 agonist SR11255 EC50 = 2200 nM PMID: 7650690  RAR_gamma
ZINC13743076 agonist SR11332 EC50 = 160 nM PMID: 7650690 
RAR_alpha
ZINC13743085 agonist SR11269 EC50 = 850 nM PMID: 7650690 
RAR_alpha
ZINC13757372 agonist Compound 11 Ki = 400 nM EC50 = 8 nM PMID: 8765503 RXR_alpha
ZINC13757374 agonist Compound12 Ki = 3115 nM EC50 = 31 nM PMID: 8765503
ZINC13758053 agonist Compound 1 Kd = 4239 nM EC50 = 570 nM PMID: 8765503
RXR_alpha
ZINC13760599 agonist AGN193639 Kd = 20 +/- 2 nM EC50 = 25 +/- 4 nM PMID: 8978832
ZINC13760600 agonist Compound 2 Kd = 996 +/- 148 nM EC50 = 115 +/- 37 nM PMID: 8978832
ZINC13780871 agonist Compound 10 relative IC50 = 432 relative EC30 = 11 PMID: 9703470
RAR_alpha
ZINC13804907 agonist ER-33635 Relative IC50 = 140 +/- 20 Relative EC30 = 0.40 +/- 0 PMID: 10669568 RAR_alpha
ZINC13804910 agonist Compound 2 Relative IC50 = 100 +/- 8 Relative EC30 = 3.9 +/- 1.4 PMID: 10669568
RAR_alpha
ZINC13804915 agonist Compound 24 Relative IC50 = 290 +/- 190 Relative EC30 = 0.85 +/- 0.16 PMID: 10669568
ZINC13809527 agonist Compound 1c Relative IC50 = 690 +/- 300 Relative EC30 = 110 +/- 30 PMID: 10956201 RAR_alpha
ZINC13815202 agonist Compound 4 EC50 ratio = 100 Bioorg. Med. Chem. Lett. 1996,6,23,2859 RAR_gamma
ZINC13815342 agonist Compound 36 EC50 ratio = 17 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC13832717 agonist Compound 4 EC50 = 15 nM PMID: 8410972 RAR_alpha
ZINC13832718 agonist Compound 7 EC50 = 25 nM PMID: 8410972 RAR_alpha
ZINC13832719 agonist Compound 8 EC50 = 40 nM PMID: 8410972 RAR_alpha
ZINC13832723 agonist Compound 13 EC50 = 5 nM PMID: 8410972 RAR_alpha
ZINC13832724 agonist Compound 14 EC50 = 20 nM PMID: 8410972
RAR_alpha
ZINC26404440 agonist Compound 5 Kd = 17 nM EC50 = 4 nM Bioorg. Med. Chem. Lett.1997,7,18,2373 RAR_gamma
ZINC26404528 agonist Compound 9 Kd = 18 nM EC50 = 4 nM Bioorg. Med. Chem. Lett.1997,7,18,2373
RAR_alpha
ZINC26468527 agonist Compound 6 Kd = 211 nM EC50 = 36 nM Bioorg. Med. Chem. Lett.1997,7,18,2373 RAR_gamma
ZINC26472010 agonist Compound 7 Kd = 18 nM EC50 = 3 nM Bioorg. Med. Chem. Lett.1997,7,18,2373
RAR_alpha
ZINC26475061 agonist Compound 1 Kd = 714 nM EC50 = 170 nM Bioorg. Med. Chem. Lett.1997,7,18,2373
RAR_alpha
ZINC26475560 agonist Compound 3 Kd = 60 nM EC50 = 10 nM Bioorg. Med. Chem. Lett.1997,7,18,2373 RAR_gamma
ZINC26649488 agonist Compound 6 EC50 = 220 nM Bioorg. Med. Chem. Lett.1995,5,22,2729
RAR_gamma
ZINC26653776 agonist Compound 5 EC50 = 29 nM Bioorg. Med. Chem. Lett.1995,5,22,2729
RAR_alpha
ZINC26657237 agonist Compound 7 EC50 = 46 nM Bioorg. Med. Chem. Lett.1995,5,22,2729
RAR_alpha
ZINC26720801 agonist Compound 34 EC50 ratio = 167 Bioorg. Med. Chem. Lett. 1996 6 23 2865 RAR_gamma
ZINC26721478 agonist Compound 8 EC50 ratio = 14 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC26722733 agonist Compound 11 EC50 ratio = 75 Bioorg. Med. Chem. Lett. 1996,6,23,2859 RAR_gamma
ZINC26722746 agonist Compound 14 EC50 ratio = 100 Bioorg. Med. Chem. Lett. 1996 6 23 2865 RAR_gamma
ZINC26723573 agonist Compound 3 EC50 ratio = 6.7 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC26723692 agonist CD666 Kd = 2300 nM EC50 = 50.8 nM PMID: 1323296
RAR_alpha
ZINC26723802 agonist Compound 12 EC50 ratio = 133 Bioorg. Med. Chem. Lett. 1996 6 23 2865 RAR_gamma
ZINC26725973 agonist Compound 5 EC50 ratio = 7.5 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC26726175 agonist Compound 40 EC50 ratio = 200 Bioorg. Med. Chem. Lett. 1996 6 23 2865 RAR_gamma
ZINC26726186 agonist Compound 39 EC50 ratio = 40 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC26726205 agonist Compound 38 EC50 ratio = 0.8 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC26726337 agonist Compound 35 EC50 ratio = 133 Bioorg. Med. Chem. Lett. 1996 6 23 2865 RAR_gamma
ZINC26728419 agonist Compound 6 EC50 ratio = 25 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC26729112 agonist Compound 8 EC50 ratio = 100 Bioorg. Med. Chem. Lett. 1996,6,23,2859 RAR_gamma
ZINC26730594 agonist Compound 10 EC50 ratio = 10 Bioorg. Med. Chem. Lett. 1996,6,23,2859
RAR_alpha
ZINC26731406 agonist Compound 15 EC50 ratio = 133 Bioorg. Med. Chem. Lett. 1996 6 23 2865 RAR_gamma
ZINC26731440 agonist Compound 12 EC50 ratio = 100 Bioorg. Med. Chem. Lett. 1996,6,23,2859 RAR_gamma
ZINC26731806 agonist Compound 9 EC50 ratio = 100 Bioorg. Med. Chem. Lett. 1996,6,23,2859 RAR_gamma
ZINC26731821 agonist Compound 7 EC50 ratio = 15 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC26731825 agonist Compound 9 EC50 ratio = 4 Bioorg. Med. Chem. Lett. 1996 6 23 2865
RAR_alpha
ZINC27638789 antagonist Compound 19 Kd = 16 +/- 1 nM PMID: 10098666
RAR_alpha
ZINC27645098 antagonist Compound 18 Kd = 72 +/- 21 nM PMID: 10098666
RAR_alpha
ZINC27645104 antagonist Compound 17 Kd = 162 +/- 85 nM PMID: 10098666
RAR_alpha
ZINC27646410 antagonist Compound 14 Kd = 52 +/- 30 nM PMID: 10098666
RAR_alpha
ZINC27646416 antagonist Compound 13 Kd = 21 +/- 4 nM PMID: 10098666
RAR_alpha
ZINC27647311 antagonist Compound 8 Kd = 29 +/- 8 nM PMID: 10098666
RAR_alpha
ZINC27647825 antagonist Compound 7 Kd = 33 +/- 6 nM PMID: 10098666
RAR_alpha
ZINC27648652 antagonist Compound 16 Kd = 29 +/- 5 nM PMID: 10098666
RAR_alpha
ZINC27648730 antagonist Compound 20 Kd = 14 +/- 3 nM PMID: 10098666
RAR_alpha
ZINC27650406 antagonist Compound 15 Kd = 18 +/- 2 nM PMID: 10098666
RAR_alpha
ZINC27651543 antagonist Compound 9 Kd = 51 +/- 22 nM PMID: 10098666
RAR_alpha
ZINC27652518 antagonist Compound 12 Kd = 11 +/- 4 nM PMID: 10098666
RAR_alpha
ZINC27652522 antagonist Compound 11 Kd = 10 +/- 2 nM PMID: 10098666
RAR_alpha
ZINC27652526 antagonist Compound 10 Kd = 274 +/- 45 nM PMID: 10098666
RAR_alpha
ZINC27708371 agonist Compound 1 IC50 = 2.7 Relative EC30 = 11 PMID: 10762039 RAR_alpha
ZINC27719619 agonist Compound 2 IC50 = 0.49 Relative EC30 = 0.20 PMID: 10762039 RAR_alpha
ZINC27720272 agonist Compound 11c Relative IC50 = 110 Relative EC30 = 0.63 PMID: 10762038
RAR_alpha
ZINC27847873 antagonist Compound 2a Kd = 7 nM IC50 = 7.5 nM PMID: 10201840
RAR_alpha
ZINC27858089 antagonist Compound 1a Kd  = 4 nM IC50 = 22 nM PMID: 10201840
RAR_alpha
ZINC27866591 antagonist Compound 1b Kd = 6 nM IC50 = 15 nM PMID: 10201840
RAR_alpha
ZINC28227159 agonist Compound 12b Relative IC50 = 79 ED30 = 100 nM PMID: 11354380
RAR_alpha
ZINC28227625 agonist Compound 12d Relative IC50 = 71 ED30 = 100 nM PMID: 11354380
RAR_alpha
ZINC28227633 antagonist Compound 12e Relative IC50 = 32 IC50 = 17 nM PMID: 11354380
RAR_alpha
ZINC28227698 agonist Compound 12a Relative IC50 =579 ED30 = 2500 nM PMID: 11354380 RAR_alpha
ZINC28227892 antagonist Compound 12c Relative IC50 = 475 IC50 = 1.6 nM PMID: 11354380
RAR_alpha
ZINC28228318 antagonist Compound 12f Relative IC50 = 535 IC50 = 6.4 nM PMID: 11354380
RAR_alpha
ZINC28758393 agonist Compound 9 AC50 = 17 nM PMID: 10890152 RXR_alpha
ZINC28758554 agonist Compound 3 AC50 = 4.3 nM PMID: 10890153
RAR_alpha
ZINC28760483 agonist Compound 8 AC50 = 740 nM PMID: 10890153 RAR_gamma
ZINC28760509 agonist Compound 6 AC50 = 140 nM PMID: 10890153 RAR_alpha
ZINC28760647 agonist Compound 5 AC50 = 10 nM PMID: 10890153
RAR_gamma
ZINC34023910 antagonist BMS493 PMID: 19670208 RAR_gamma
ZINC34807014 agonist Compound 26 pEC50 = 7.4 +/- 0.3 PMID: 19239230 RAR_gamma
ZINC34807016 agonist Compound 17 PEC50 = 7.2 +/- 0.2 PMID: 19239230
ZINC34807018 agonist Compound 15 PEC50 = 7.2 +/- 0.2 PMID: 19239230
ZINC34807154 agonist Compound 23 pEC50 = 7.1 +/- 0.3 PMID: 19239230
ZINC34807156 agonist Compound 24 PEC50 = 6.9 +/- 0.2 PMID: 19239230
ZINC34807158 agonist Compound 16 PEC50 = 6.6 +/- 0.3 PMID: 19239230
ZINC38493164 agonist Compound 9 EC50 = 0.3 nM PMID: 19058965
RAR_alpha
ZINC40895923 agonist Compound 25 PEC50 = 7.2 +/- 0.2 PMID: 19239230
ZINC40897866 agonist Compound 18 PEC50 = 7.7 +/- 0.1 PMID: 19239230 RAR_alpha
ZINC42891672 agonist Compound 8 PEC50 = 7.4 +/- 0.2 PMID: 19239230
RAR_alpha
ZINC44417190 agonist Compound 11 PEC50 = 7.0 +/- 0.2 PMID: 19239230
ZINC44417269 agonist Compound 22 PEC50 = 6.0 +/- 0.2 PMID: 19239230
ZINC44418472 agonist Compound 5 pEC50 = 6.9 +/ - 0.2 PMID: 19239230
ZINC59401622 agonist Compound 10 PEC50 = 7.0 +/- 0.4 PMID: 19239230
ZINC59401746 agonist Compound 9 pEC50 = 6.2 +/- 0.7 PMID: 19239230
ZINC65731563 agonist AGN193836 Kd = 17374 +/- 6347 nM PMID: 8759622 RAR_alpha