Compound ID |
Pharmacological profile |
Compound name |
Binding data |
Activity data |
Bibliographic ref |
Cross-reactivity |
CHEMBL468623 |
agonist |
Compound 10 |
|
EC50 = 520 nM |
PMID: 19058965 |
|
ZINC00006827 |
agonist |
Compound 11b |
Relative IC50 = 13 |
Relative EC30 =0.19 |
PMID: 10762038 |
RAR_beta |
ZINC00007543 |
agonist |
Compound 1b |
Relative IC50 = 1.4 +/- 0.3 |
Relative EC30 = 0.37 +/- 0.02 |
PMID: 10956201 |
RAR_beta |
ZINC00017723 |
agonist |
Compound 11a |
IC50 = 24 |
Relative EC30 = 2.8 |
PMID: 10762039 |
|
ZINC00538415 |
agonist |
AM80 |
IC50 = 124 nnM |
EC50 = 45 +/- 28 nM |
PMID: 7791761 |
|
ZINC00583260 |
agonist |
Compound 1f |
Relative IC50 = 1.9 +/- 0.4 |
Relative EC30 = 0.29 +/- 0.04 |
PMID: 10956201 |
RAR_beta |
ZINC00840991 |
agonist |
Compound 20b |
Relative IC50 = 19 +/- 5 |
ED30 = 0.21 +/- 0.02 nM |
PMID: 10669568 |
RAR_gamma |
ZINC01397300 |
agonist |
Compound 1 |
|
EC50 = 4µM |
PMID: 11405897 |
|
ZINC01483343 |
agonist |
Compound 16 |
|
EC50 = 225 nM |
PMID: 10543887 |
RAR_gamma |
ZINC01532939 |
agonist |
SR11004 |
|
EC50 = 4500 nM |
PMID: 7650690 |
|
ZINC01533168 |
agonist |
Compound 190121 |
Kd = 135 nM |
EC50 = 435 nM |
PMID: 11277515 |
|
ZINC01538323 |
antagonist |
Ro-41-5253 |
IC50 = 60 nM |
|
PMID: 8264595 |
|
ZINC01538326 |
antagonist |
Ro 46-5471 |
IC50 = 27 nM |
|
PMID: 8264595 |
|
ZINC01539148 |
antagonist |
ER27191 |
IC50 = 0.34 nM |
IC50 = 4.9 nM |
PMID: 7636879 |
RAR_gamma |
ZINC01539149 |
antagonist |
Compound 55 |
IC50 = 0.91 nM |
IC50 = 1.3 nM |
PMID: 7636879 |
RAR_gamma |
ZINC01539150 |
antagonist |
Compound 40 |
IC50 = 0.16 nM |
IC50 = 5.6 nM |
PMID: 7636879 |
RAR_gamma |
ZINC01539151 |
antagonist |
Compound 4 |
IC50 = 16 nM |
IC50 = 0.12 µM |
PMID: 7636879 |
RAR_gamma |
ZINC01542199 |
agonist |
Tazarotene |
|
EC50 = 63 nM |
PMID: 19058965 |
|
ZINC01543482 |
antagonist |
AGN193109 |
Kd = 16 +/- 5 |
IC50 = 9 +/- 1 |
PMID: 8798442 |
RAR_gamma |
ZINC01550227 |
antagonist |
Compound 1 |
Kd = 148 nM |
IC50 = 210 nM |
PMID: 11277517 |
|
ZINC01550228 |
antagonist |
Compound 2 |
Kd = 136 nM |
Ic50 = 220 nM |
PMID: 11277517 |
|
ZINC01550229 |
antagonist |
Compound 3 |
Kd = 875 nM |
IC50 = 350 nM |
PMID: 11277517 |
|
ZINC01550230 |
antagonist |
Compound 4 |
Kd = 252 nM |
IC50 = 129 nM |
PMID: 11277517 |
|
ZINC01550918 |
agonist |
Compound 14 |
|
EC50 = 1400 nM |
PMID: 9733501 |
|
ZINC01891052 |
agonist |
LG100567 |
Ki = 63.5 +/- 8.5 nM |
EC50 = 65 +/- 12 nM |
PMID: 8709094 |
|
ZINC01891456 |
agonist |
Compound 37 |
|
EC50= 63 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC01891459 |
agonist |
Compound 33 |
|
EC50= 25 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC01891905 |
agonist |
AGN193835 |
Kd = 4.4 +/- 2.3 nM |
|
PMID: 8759622 |
RAR_beta |
ZINC01893319 |
antagonist |
BMS614 |
Ki = 2.5 nM |
|
PMID: 10421757 |
|
ZINC01895357 |
antagonist |
Compound 5 |
Kd = 1.5 +/- 0.8 nM |
|
PMID: 9258350 |
|
ZINC01895361 |
antagonist |
Compound 1 |
Kd = 27 +/- 15 nM |
|
PMID: 9258350 |
|
ZINC01895365 |
antagonist |
Compound 2 |
Kd = 5.7 +/- 0.9 nM |
|
PMID: 9258350 |
|
ZINC01895368 |
antagonist |
Compound 3 |
Kd = 32 +/- 15 nM |
|
PMID: 9258350 |
RAR_beta |
ZINC01895370 |
antagonist |
Compound 4 |
Kd = 2.8 +/- 1.1 nM |
|
PMID: 9258350 |
|
ZINC01896358 |
antagonist |
Compound 2b |
Kd = 17 nM |
IC50 = 6.5 nM |
PMID: 10201840 |
|
ZINC01909562 |
agonist |
AGN195183 |
Kd = 3 nM |
EC50 = 200 nM |
PMID: 12372520 |
|
ZINC01996688 |
antagonist |
Compound 3a |
Kd = 5.5 nM |
IC50 = 1.5 nM |
PMID: 10201840 |
|
ZINC02007450 |
antagonist |
AGN194310 |
Kd = 3 +/- 2 nnM |
IC50 = 67 nM |
PMID: 10465407 |
|
ZINC02008474 |
agonist |
Compound 5a |
Kd = 644 nM |
EC50 = 59 nM |
PMID: 12482435 |
|
ZINC02030426 |
agonist |
Compound 3 |
|
pEC50 = 5.6 +/- 0.0 |
PMID: 19239230 |
RAR_beta |
ZINC02568233 |
agonist |
TTNPB |
IC50 = 36 +/- 5.1 |
EC50 = 30 +/- 6 nM |
PMID: 7791761 |
|
ZINC03777578 |
agonist |
Compound 13 |
|
EC50 = 740 nM |
PMID: 9733501 |
|
ZINC03784077 |
agonist |
AM580 |
Kd = 36 nM |
EC50 = 2 nM |
PMID: 12372520 |
RAR_gamma |
ZINC03784182 |
agonist |
Compound5 |
Ki = 1100 +/- 70 nM |
AC50 = 37 +/- 7 nM |
PMID: 8544177 |
RAR_gamma |
ZINC03871916 |
agonist |
Compound 1 |
|
EC50 = 13 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC03936873 |
agonist |
Compound 7 |
Ki = 6500 +/- 570 nM |
AC50 = 33 +/- 27 nM |
PMID: 8544177 |
RAR_gamma |
ZINC03951146 |
agonist |
ER-34617 |
Relative IC50 = 2.2 +/- 1.5 |
Relative EC30 = 0.32 +/- 0.03 |
PMID: 10669568 |
|
ZINC03974554 |
agonist |
Compound 12a |
IC50 = 9.7 |
Relative EC30 = 1.8 |
PMID: 10762039 |
|
ZINC03990465 |
agonist |
Compound 2 |
|
EC50 = 0.2 µM |
PMID: 16033272 |
|
ZINC04097702 |
agonist |
B-cryptoxanthin |
|
|
PMID: 17521617 |
|
ZINC04475360 |
agonist |
arotinoid |
IC50 = 36 nM |
EC50 = 2.1 nM |
PMID: 8264595 |
|
ZINC04825704 |
agonist |
ALRT1550 |
Ki = 1.1 +/- 0.1 nM |
EC50 = 4.0 +/- 0.6 nM |
PMID: 8709094 |
|
ZINC05762192 |
agonist |
Compound 4 |
|
ED30 = 54 µM |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
RAR_beta |
ZINC05762247 |
agonist |
Compound 3 |
Ki = 1120 +/- 200 nM |
AC50 = 150 +/- 21 nM |
PMID: 8544177 |
|
ZINC06070388 |
agonist |
3-methyl-TTNPB |
IC50 = 638 +/- 75 nM |
EC50 = 340 +/- 30 nM |
PMID: 8308867 |
|
ZINC12358651 |
agonist |
All-trans-retinoic acid |
IC50 = 15 +/- 2 nM |
EC50 = 350 +/- 31 nM |
PMID: 7791761 |
|
ZINC12661824 |
agonist |
9-cis-retinoic acid |
IC50 = 7+/- 1.7 nM |
EC50 =191 +/- 20 nM |
PMID: 7791761 |
RAR_beta |
ZINC13558478 |
agonist |
Compound 9 |
|
AC50 = 14 nM |
PMID: 10890153 |
|
ZINC13648516 |
agonist |
Compound 7a |
|
EC50 = 20.3 µM |
PMID: 16033272 |
|
ZINC13648519 |
agonist |
Compound 7b |
|
EC50 = 18.2 µM |
PMID: 16033272 |
|
ZINC13649044 |
agonist |
AGN 193312 |
Kd = 2 nM |
EC50 = 8 nM |
PMID: 12372520 |
|
ZINC13649046 |
agonist |
AGN 193931 |
Kd = 7 nM |
EC50 = 94 nM |
PMID: 12372520 |
|
ZINC13649048 |
agonist |
AGN 194078 |
Kd = 3 nM |
EC50 = 112 nM |
PMID: 12372520 |
|
ZINC13652275 |
agonist |
Compound 18 |
|
EC50 = 420 nM |
PMID: 9733501 |
RAR_gamma |
ZINC13652276 |
agonist |
Compound 1 |
|
EC50 = 1128 nM |
PMID: 10479291 |
|
ZINC13652278 |
agonist |
Compound 15 |
|
EC50 = 1000 nM |
PMID: 9733501 |
|
ZINC13652279 |
agonist |
Compound 17 |
|
EC50 = 2300 nM |
PMID: 9733501 |
RAR_gamma |
ZINC13652284 |
agonist |
Compound 16 |
|
EC50 = 1100 nM |
PMID: 9733501 |
RAR_gamma |
ZINC13676272 |
agonist |
Compound 28 |
|
PEC50 = 6.2 +/- 0.3 |
PMID: 19239230 |
|
ZINC13734373 |
agonist |
3-ethyl-TTNPB |
IC50 = 100 +/- 49 nM |
EC50 = 1700 +/- 118 nM |
PMID: 8308867 |
|
ZINC13738449 |
agonist |
SR11201 |
|
EC50 = 2300 nM |
PMID: 7650690 |
RAR_beta |
ZINC13742306 |
agonist |
Compound 4 |
|
EC50 = 2690 nM |
PMID: 7636843 |
|
ZINC13742689 |
antagonist |
Compound 3 |
IC50 = 17 nM |
IC50 = 0.5 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742692 |
antagonist |
Compound 26 |
IC50 = 14 nM |
IC50 = 0.36 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742693 |
antagonist |
Compound 27 |
IC50 = 19 nM |
IC50 = 0.52 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742694 |
antagonist |
Compound 29 |
IC50 = 1.2 nM |
IC50 = 0.21 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742695 |
antagonist |
Compound 30 |
IC50 = 0.59 nM |
IC50 = 33 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742696 |
antagonist |
Compound 32 |
IC50 = 2.3 nM |
IC50 = 84 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742697 |
antagonist |
Compound 33 |
IC50 = 0.14 nM |
IC50 = 17 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742698 |
antagonist |
Compound 34 |
IC50 = 16 nM |
IC50 = 1.3 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742699 |
antagonist |
Compound 35 |
IC50 = 5.6 nM |
IC50 = 0.65 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742700 |
antagonist |
Compound 36 |
IC50 = 3.2 nM |
IC50 = 0.49 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742701 |
antagonist |
Compound 37 |
IC50 = 3.4 nM |
IC50 = 51 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742702 |
antagonist |
Compound 38 |
IC50 = 4.5 nM |
IC50 = 0.54 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742703 |
antagonist |
Compound 54 |
IC50 = 1.5 nM |
IC50 = 56 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742704 |
antagonist |
Compound 39 |
IC50 = 19 nM |
IC50 = 0.1 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742705 |
antagonist |
Compound 42 |
IC50 = 4.7 nM |
IC50 = 78 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742706 |
antagonist |
Compound 51 |
IC50 = 11 nM |
IC50 = 77 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742707 |
antagonist |
Compound 43 |
IC50 = 13 nM |
IC50 = 1.1 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742708 |
antagonist |
Compound 45 |
IC50 = 0.97 nM |
IC50 = 69 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742709 |
antagonist |
Compound 46 |
IC50 = 22 nM |
IC50 = 0.17 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742710 |
antagonist |
Compound 47 |
IC50 = 3.7 nM |
IC50 = 37 nM |
PMID: 7636879 |
RAR_gamma |
ZINC13742711 |
antagonist |
Compound 48 |
IC50 = 2.9 nM |
IC50 = 0.23 µM |
PMID: 7636879 |
RAR_gamma |
ZINC13742712 |
antagonist |
Compound 49 |
IC50 = 30 nM |
IC50 = 0.3 µM |
PMID: 7636879 |
|
ZINC13743076 |
agonist |
SR11332 |
|
EC50 = 470 nM |
PMID: 7650690 |
RAR_beta |
ZINC13743081 |
agonist |
SR11236 |
|
EC50 = 1200 NM |
PMID: 7650690 |
|
ZINC13743082 |
agonist |
SR11203 |
|
EC50 = 540 nM |
PMID: 7650690 |
RAR_gamma |
ZINC13743085 |
agonist |
SR11269 |
|
EC50 = 2500 nM |
PMID: 7650690 |
|
ZINC13745041 |
agonist |
Compound 1 |
Ki = 6500 +/- 2500 nM |
AC50 = 200 +/- 80 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745049 |
agonist |
Compound 9 |
Ki = 695 +/- 248 nM |
AC50 = 7.5 +/- 4 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745059 |
agonist |
Compound 12 |
Ki = 5000 nM |
AC580 = 83 +/- 28 nM |
PMID: 8544177 |
|
ZINC13745065 |
agonist |
Compound 14 |
Ki = 130 +/- 50 nM |
AC50 = 30 +/- 5 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745067 |
antagonist |
Compound 15 |
Ki = 834 +/- 54 nM |
IC50 = 700 +/- 125 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745069 |
agonist |
Compound 16 |
Ki = 420 +/- 110 nM |
AC50 = 30 +/- 16 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745071 |
agonist |
Compound 17 |
Ki = 1056 +/- 88 nM |
AC50 = 300 +/- 60 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745073 |
agonist |
Compound 18 |
Ki = 460 +/- 100 nM |
AC50 = 100 +/- 29 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745075 |
agonist |
Compound 19 |
Ki = 1144 +/- 67 nM |
AC50 = 66 +/- 24 nM |
PMID: 8544177 |
RAR_gamma |
ZINC13745077 |
agonist |
Compound 20 |
Ki = 610 +/- 29 nM |
AC50 = 1 +/- 0.41 nM |
PMID: 8544177 |
|
ZINC13780871 |
agonist |
Compound 10 |
Relative IC50 = 372 |
relative EC30 = 21 |
PMID: 9703470 |
|
ZINC13781194 |
agonist |
Compound 10 |
|
EC50 = 800 nM |
PMID: 9733501 |
|
ZINC13781195 |
agonist |
Compound 12 |
|
EC50 = 620 nM |
PMID: 9733501 |
RAR_gamma |
ZINC13781196 |
agonist |
Compound 19 |
|
EC50 = 1100 nM |
PMID: 9733501 |
RAR_gamma |
ZINC13800362 |
agonist |
Compound 2 |
|
EC50 = 796 nM |
PMID: 10479291 |
RAR_gamma |
ZINC13800364 |
agonist |
Compound 3 |
|
EC50 = 217 nM |
PMID: 10479291 |
|
ZINC13804907 |
agonist |
ER-33635 |
Relative IC50 = 40 +/- 2 |
Relative EC30 = 0.15 +/- 0.04 |
PMID: 10669568 |
RAR_beta |
ZINC13804910 |
agonist |
Compound 2 |
Relative IC50 = 0.45 +/- 0.15 |
Relative EC30 = 0.34 +/- 0.1 |
PMID: 10669568 |
|
ZINC13804918 |
agonist |
Compound 3b |
Relative IC50 = 32 +/- 1 |
ED30 = 2.1 +/- 0.4 nM |
PMID: 10669568 |
RAR_gamma |
ZINC13804921 |
agonist |
Compound 3c |
Relative IC50 = 130 +/- 40 |
ED30 = 40 +/- 16 nM |
PMID: 10669568 |
RAR_gamma |
ZINC13804924 |
agonist |
Compound 20c |
Relative IC50 = 2.4 +/- 1.4 |
ED30 = 9.5 +/- 3.5 nM |
PMID: 10669568 |
RAR_gamma |
ZINC13804926 |
agonist |
Compound 27 b |
Relative IC50 = 83 +/- 9 |
ED30 = 11 +/- 2 nM |
PMID: 10669568 |
RAR_gamma |
ZINC13809526 |
agonist |
Compound 1a |
Relative IC50 = 1.6 +/- 0.1 |
Relative EC30 = 0.8 +/- 0.14 |
PMID: 10956201 |
|
ZINC13809527 |
agonist |
Compound 1c |
Relative IC50 = 1.5 +/- 0.3 |
Relative EC30 = 0.7 +/- 0.15 |
PMID: 10956201 |
RAR_beta |
ZINC13809529 |
agonist |
Compound 1d |
Relative IC50 = 15 +/- 3 |
Relative EC30 = 6 +/- 2.1 |
PMID: 10956201 |
|
ZINC13809530 |
agonist |
Compound 1e |
Relative IC50 = 2.5 +/- 0.3 |
Relative EC30 = 0.8 +/- 0.17 |
PMID: 10956201 |
|
ZINC13809531 |
agonist |
Compound 1g |
Relative IC50 = 16 +/- 3 |
Relative EC30 = 1.0 +/- 0.4 |
PMID: 10956201 |
|
ZINC13809532 |
agonist |
Compound 1h |
Relative IC50 = 9.4 +/- 5.0 |
Relative EC30 = 2.0 +/- 0.5 |
PMID: 10956201 |
|
ZINC13809533 |
agonist |
Compound 1i |
Relative IC50 = 12 +/- 8 |
Relative EC30 = 3.1 +/- 1.1 |
PMID: 10956201 |
|
ZINC13809534 |
agonist |
Compound 1j |
Relative IC50 = 6.1 +/- 0.4 |
Relative EC30 = 1.3 +/- 0.6 |
PMID: 10956201 |
|
ZINC13809535 |
agonist |
Compound 1k |
Relative IC50 = 62 +/- 21 |
Relative EC30 = 2.4 +/- 0.5 |
PMID: 10956201 |
|
ZINC13815342 |
agonist |
Compound 36 |
|
EC50 = 25 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC13815366 |
agonist |
Compound 2 |
Ki = 58 nM |
AC50 = 58 nM |
Bioorg. Med. Chem. Lett.1997, 7,17,2289 |
RAR_gamma |
ZINC13815373 |
agonist |
Compound 7 |
Ki = 300 nM |
AC50 = 300 nM |
Bioorg. Med. Chem. Lett.1997, 7,17,2289 |
RAR_gamma |
ZINC13815446 |
agonist |
Compound 2 |
|
EC50 = 2 µM |
PMID: 11405897 |
|
ZINC13815519 |
agonist |
Compound 6 |
Ki = 305 nM |
AC50 = 305 nM |
Bioorg. Med. Chem. Lett.1997, 7,17,2289 |
|
ZINC13815522 |
agonist |
Compound 4 |
Ki = 107 nM |
AC50 = 107 nM |
Bioorg. Med. Chem. Lett.1997, 7,17,2289 |
RAR_gamma |
ZINC13832717 |
agonist |
Compound 4 |
|
EC50 = 27 nM |
PMID: 8410972 |
RAR_beta |
ZINC13832718 |
agonist |
Compound 7 |
|
EC50 = 37 nM |
PMID: 8410972 |
RAR_beta |
ZINC13832719 |
agonist |
Compound 8 |
|
EC50 = 45 nM |
PMID: 8410972 |
RAR_beta |
ZINC13832723 |
agonist |
Compound 13 |
|
EC50 = 240 nM |
PMID: 8410972 |
RAR_beta |
ZINC13832724 |
agonist |
Compound 14 |
|
EC50 = 550 nM |
PMID: 8410972 |
|
ZINC26385838 |
agonist |
Compound 3 |
Ki = 34 nM |
AC50 = 34 nM |
Bioorg. Med. Chem. Lett.1997, 7,17,2289 |
RAR_gamma |
ZINC26404528 |
agonist |
Compound 7 |
Kd = 52 nM |
EC50 = 17 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
|
ZINC26472010 |
agonist |
Compound 7 |
Kd = 52 nM |
EC50 = 17 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
|
ZINC26475061 |
agonist |
Compound 1 |
Kd = 5202 nM |
EC50 = 2300 nM |
Bioorg. Med. Chem. Lett.1997,7,18,2373 |
|
ZINC26653776 |
agonist |
Compound 5 |
|
EC50 = 690 nM |
Bioorg. Med. Chem. Lett.1995,5,22,2729 |
|
ZINC26657237 |
agonist |
Compound 7 |
|
EC50 = 210 nM |
Bioorg. Med. Chem. Lett.1995,5,22,2729 |
RAR_beta |
ZINC26721478 |
agonist |
Compound 8 |
|
EC50 = 8 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC26723573 |
agonist |
Compound 3 |
|
EC50 = 100 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC26723692 |
agonist |
CD666 |
Kd = 2240 nM |
AC50 = 149 nM |
PMID: 1323296 |
|
ZINC26725973 |
agonist |
Compound 5 |
|
EC50 = 25 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC26726186 |
agonist |
Compound 39 |
|
EC50 = 38 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC26726205 |
agonist |
Compound 38 |
|
EC50 = 1.3 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
RAR_beta |
ZINC26728419 |
agonist |
Compound 6 |
|
EC50 = 25 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
RAR_beta |
ZINC26730594 |
agonist |
Compound 10 |
|
ED30 = 92 µM |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
RAR_beta |
ZINC26731821 |
agonist |
Compound 7 |
|
EC50 = 25 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC26731825 |
agonist |
Compound 9 |
|
EC50 = 10 |
Bioorg. Med. Chem. Lett. 1996 6 23 2865 |
|
ZINC26850547 |
agonist |
Compound 2 |
IC50 = 19 nM |
ED1/3 = 90 nM |
PMID: 7636879 |
|
ZINC27638789 |
antagonist |
Compound 19 |
Kd = 60 +/- 28 nM |
|
PMID: 10098666 |
RAR_beta |
ZINC27645098 |
antagonist |
Compound 18 |
Kd = 229 +/- 48 nM |
|
PMID: 10098666 |
RAR_beta |
ZINC27645104 |
antagonist |
Compound 17 |
Kd = 919 +/- 250 nM |
|
PMID: 10098666 |
RAR_beta |
ZINC27646410 |
antagonist |
Compound 14 |
Kd = 85 +/- 45 nM |
|
PMID: 10098666 |
|
ZINC27646416 |
antagonist |
Compound 13 |
Kd = 178 +/- 81 nM |
|
PMID: 10098666 |
|
ZINC27647311 |
antagonist |
Compound 8 |
Kd = 103 +/- 17 nM |
|
PMID: 10098666 |
|
ZINC27647825 |
antagonist |
Compound 7 |
Kd = 147 +/- 27 nM |
|
PMID: 10098666 |
|
ZINC27648652 |
antagonist |
Compound 16 |
Kd = 44 +/- 7 nM |
|
PMID: 10098666 |
|
ZINC27648730 |
antagonist |
Compound 20 |
Kd = 38 +/- 5 nM |
|
PMID: 10098666 |
RAR_beta |
ZINC27650406 |
antagonist |
Compound 15 |
Kd = 58 +/- 9 nM |
|
PMID: 10098666 |
RAR_beta |
ZINC27651543 |
antagonist |
Compound 9 |
Kd = 267 +/- 175 nM |
|
PMID: 10098666 |
RAR_beta |
ZINC27652518 |
antagonist |
Compound 12 |
Kd = 90 +/- 10 nM |
|
PMID: 10098666 |
|
ZINC27652522 |
antagonist |
Compound 11 |
Kd = 40 +/- 16 nM |
|
PMID: 10098666 |
|
ZINC27652526 |
antagonist |
Compound 10 |
Kd = 1051 +/- 802 nM |
|
PMID: 10098666 |
|
ZINC27708371 |
agonist |
Compound 1 |
IC50 = 2.7 |
Relative EC30 = 20 |
PMID: 10762039 |
RAR_beta |
ZINC27710262 |
agonist |
Compound 11b |
IC50 = 15 |
Relative EC30 = 49 |
PMID: 10762039 |
|
ZINC27710632 |
agonist |
Compound 11a |
Relative IC50 = 98 |
Relative EC30 = 1.0 +/- 0.4 |
PMID: 10762038 |
|
ZINC27713389 |
agonist |
Compound 12b |
IC50 = 50 |
Relative EC30 = 4.5 |
PMID: 10762039 |
|
ZINC27718750 |
agonist |
Compound 11f |
IC50 < 1.0 |
Relative EC30 = 1.1 |
PMID: 10762039 |
|
ZINC27719619 |
agonist |
Compound 2 |
IC50 = 0.49 |
Relative EC30 = 0.27 |
PMID: 10762039 |
RAR_beta |
ZINC27720272 |
agonist |
Compound 11c |
Relative IC50 = 7.6 |
Relative EC30 =0.22 |
PMID: 10762038 |
|
ZINC27847873 |
antagonist |
Compound 2a |
Kd = 14 nM |
IC50 = 5.5 nM |
PMID: 10201840 |
|
ZINC27858089 |
antagonist |
Compound 1a |
Kd = 13 nM |
IC50 = 20 nM |
PMID: 10201840 |
|
ZINC27866591 |
antagonist |
Compound 1b |
Kd = 15 nM |
IC50 = 20 nM |
PMID: 10201840 |
|
ZINC28227159 |
agonist |
Compound 12b |
Relative IC50 = 1.3 |
ED30 = 100 nM |
PMID: 11354380 |
|
ZINC28227625 |
agonist |
Compound 12d |
Relative IC50 = 1.7 |
ED30 = 100 nM |
PMID: 11354380 |
RAR_beta |
ZINC28227633 |
antagonist |
Compound 12e |
Relative IC50 = 0.7 |
IC50 = 17 nM |
PMID: 11354380 |
RAR_beta |
ZINC28227698 |
agonist |
Compound 12a |
Relative IC50 =5.7 |
ED30 = 2500 nM |
PMID: 11354380 |
RAR_beta |
ZINC28227892 |
antagonist |
Compound 12c |
Relative IC50 = 0.8 |
IC50 = 1.6 nM |
PMID: 11354380 |
|
ZINC28228318 |
antagonist |
Compound 12f |
Relative IC50 = 1.8 |
IC50 = 6.4 nM |
PMID: 11354380 |
|
ZINC28463728 |
agonist |
Compound 8b |
|
EC50 = 6.4 µM |
PMID: 16033272 |
|
ZINC28758554 |
agonist |
Compound 3 |
|
AC50 = 1.0 nM |
PMID: 10890153 |
|
ZINC28760010 |
agonist |
Compound 4 |
|
AC50 = 79 nM |
PMID: 10890153 |
RXR_alpha |
ZINC28760509 |
agonist |
Compound 6 |
|
AC50 = 370 nM |
PMID: 10890153 |
RAR_beta |
ZINC33973452 |
antagonist |
Compound 7 |
|
|
PMID: 18702457 |
|
ZINC34008167 |
agonist |
BMS753 |
Ki = 2 nM |
|
PMID: 10421757 |
|
ZINC38493164 |
agonist |
Compound 9 |
|
EC50 = 0.6 nM |
PMID: 19058965 |
|
ZINC40392355 |
antagonist |
Compound 24 |
|
|
PMID: 18702457 |
|
ZINC40411361 |
antagonist |
Compound 11h |
|
|
PMID: 18702457 |
|
ZINC40897866 |
agonist |
Compound 18 |
|
pEC50 = 5.8 |
PMID: 19239230 |
RAR_beta |
ZINC42891672 |
agonist |
Compound 8 |
|
pEC50 = 5.7 |
PMID: 19239230 |
|
ZINC65731563 |
agonist |
AGN193836 |
Kd = 4 nM |
EC50 = 290 nM |
PMID: 12372520 |
RAR_beta |
|
|
|
|
|
|
|