Compound ID Pharmacological profile Compound name Binding data Activity data Bibliographic ref Cross-reactivity
CHEMBL101914 antagonist Compound 13 IC50 = 354 +/- 85 nM PMID: 9464360
CHEMBL102403 antagonist Compound 22 IC50 = 1592 +/- 460 nM PMID: 9464360
CHEMBL102754 antagonist Compound 26 IC50 = 1358 +/- 299 nM PMID: 9464360 PR
CHEMBL103232 antagonist Compound 16 IC50 = 977 +/- 706 nM PMID: 9464360
CHEMBL1094114 antagonist Compound 5a IC50 = 59 nM PMID: 20672820
CHEMBL1214688 antagonist Compound 4i IC50 = 180 nM PMID: 20672822
CHEMBL1214766 antagonist Compound 12a IC50 = 243 nM PMID: 20672822
CHEMBL1214767 antagonist Compound 12b IC50 = 535 nM PMID: 20672822
CHEMBL1214838 antagonist Compound 12c IC50 = 56 nM PMID: 20672822
CHEMBL1214840 antagonist Compound 12d IC50 = 284 nM PMID: 20672822
CHEMBL1214841 antagonist Compound 12e IC50 = 56 nM PMID: 20672822
CHEMBL1214903 antagonist Compound 12f IC50 = 127 nM PMID: 20672822
CHEMBL1214968 antagonist Compound 12l IC50 = 410 nM PMID: 20672822
CHEMBL1214969 antagonist Compound 12m IC50 = 763 nM PMID: 20672822
CHEMBL1214971 antagonist Compound 15b IC50 = 441 nM PMID: 20672822
CHEMBL1215045 antagonist Compound 4a IC50 = 621 nM PMID: 20672820
CHEMBL1215047 antagonist Compound 4c IC50 = 224 nM PMID: 20672820
CHEMBL1215048 antagonist Compound 4d IC50 = 208 nM PMID: 20672820
CHEMBL1215049 antagonist Compound 4e IC50 = 553 nM PMID: 20672820
CHEMBL1215052 antagonist Compound 15e IC50 = 151 nM PMID: 20672822
CHEMBL1215053 antagonist Compound 12h IC50 = 383 nM PMID: 20672822
CHEMBL1215123 antagonist Compound 4h IC50 = 888 nM PMID: 20672820
CHEMBL1215124 antagonist Compound 4i IC50 = 518 nM PMID: 20672820
CHEMBL1215125 antagonist Compound 4j IC50 = 702 nM PMID: 20672820
CHEMBL1215193 antagonist Compound 4m IC50 = 309 nM PMID: 20672820
CHEMBL1215195 antagonist Compound 4o IC50 = 288 nM PMID: 20672820
CHEMBL1215259 antagonist Compound 4r IC50 = 319 nM PMID: 20672820
CHEMBL1215260 antagonist Compound 4s IC50 = 78 nM PMID: 20672820
CHEMBL1215261 antagonist Compound 4t IC50 = 574 nM PMID: 20672820
CHEMBL1215325 antagonist Compound 5b IC50 = 329 nM PMID: 20672820
CHEMBL1215326 antagonist Compound 5c IC50 = 661 nM PMID: 20672820
CHEMBL1215327 antagonist Compound 5d IC50 = 201 nM PMID: 20672820
CHEMBL1215403 antagonist Compound 5g IC50 = 92 nM PMID: 20672820 PR
CHEMBL1215404 antagonist Compound 5h IC50 = 594 nM PMID: 20672820
CHEMBL1215405 antagonist Compound 5i IC50 = 232 nM PMID: 20672820
CHEMBL1215406 antagonist Compound 5j IC50 = 64 nM PMID: 20672820 PR
CHEMBL1215407 antagonist Compound 5k IC50 = 208 nM PMID: 20672820
CHEMBL1215480 antagonist Compound 5l IC50 = 58 nM PMID: 20672820 PR
CHEMBL1215481 antagonist Compound 5m IC50 = 655 nM PMID: 20672820
CHEMBL1215482 antagonist Compound 5n IC50 = 923 nM PMID: 20672820
CHEMBL1215483 antagonist Compound 5o IC50 = 1090 nM PMID: 20672820
CHEMBL1215484 antagonist Compound 5p IC50 = 852 nM PMID: 20672820
CHEMBL1215549 antagonist Compound 5r IC50 = 16 nM PMID: 20672820
CHEMBL1215550 antagonist Compound 5s IC50 = 52 nM PMID: 20672820
CHEMBL1215551 antagonist Compound 5t IC50 = 275 nM PMID: 20672820
CHEMBL1215552 antagonist Compound 7a IC50 = 9 nM PMID: 20672820
CHEMBL1215620 antagonist Compound 7b IC50 = 54 nM PMID: 20672820
CHEMBL1215621 antagonist Compound 7c IC50 = 123 nM PMID: 20672820
CHEMBL1215689 antagonist Compound 4a IC50 = 460 nM PMID: 20672822
CHEMBL1215755 antagonist Compound 4d IC50 = 83 nM PMID: 20672822
CHEMBL1215757 antagonist Compound 4f IC50 = 784 nM PMID: 20672822
CHEMBL130141 antagonist Compound 8b IC50 = 363 +/- 120 nM PMID: 12954062
CHEMBL134260 antagonist Compound 7 IC50 = 1000 +/- 500 nM PMID: 10743938 GR
CHEMBL134277 antagonist Compound 18b IC50 = 1900 +/- 780 nM PMID: 12954062 AR
CHEMBL134421 antagonist Compound 6 IC50 = 3000 +/- 500 nM PMID: 9784110 PR
CHEMBL1480 antagonist felodipine IC50 = 170 +/- 30 nM PMID: 18250364
CHEMBL1672542 antagonist Compound 7a IC50 = 64.1 +/- 25.8 nM ACS Med. Chem. Lett., 2011, 2, 2, 148 PR
CHEMBL1928872 antagonist Compound 17 IC50 = 510 nM PMID: 22866979
CHEMBL1929036 antagonist Compound 14k IC50 = 80 nM (65-100) IC50 = 150 nM (80-280) PMID: 22074142
CHEMBL211039 antagonist Compound 27 IC50  = 21 +/- 4 µM PMID: 16759088
CHEMBL2112397 antagonist Compound 3 Kd = 20 +/- 2 nM IC50 = 700 nM PMID: 8709117
CHEMBL2112398 antagonist Compound 2 Kd = 20 +/- 1 nM IC50 = 900 nM PMID: 8709117
CHEMBL2181925 antagonist Compound 1 Ki = 0.40 nM PMID: 22866979
CHEMBL2181929 antagonist Compound 9 PMID: 22866979
CHEMBL2181931 antagonist Compound 11 IC50 = 22 nM PMID: 22866979
CHEMBL2181933 antagonist Compound 15 IC50 = 7.1 nM IC50 = 19 nM PMID: 22866979
CHEMBL259820 antagonist LGD5552 Ki = 149 +/- 30 nM PMID: 18032610
CHEMBL286595 antagonist Compound 15 IC50 = 1525 +/- 504 nM PMID: 9464360
CHEMBL317921 antagonist Compound 25 IC50 = 1062 +/- 945 nM PMID: 9464360
CHEMBL318513 antagonist Compound 24 IC50 = 2219 +/- 644 nM PMID: 9464360 PR
CHEMBL320690 antagonist Compound 18 IC50 = 748 +/- 580 nM PMID: 9464360
CHEMBL337856 antagonist Compound 9d IC50 = 1850 +/- 500 nM PMID: 12954062
CHEMBL410683 antagonist Z-guggulsterone Ki = 1880 +/- 390 nM IC50 = 6060 +/- 310 nM PMID: 16250653
FXR_alpha
CHEMBL423620 antagonist Compound 27 IC50 = 570 nM PMID: 9871534
CHEMBL430855 antagonist Compound 19 IC50 = 1068 +/- 406 nM PMID: 9464360
CHEMBL453579 antagonist Compound 5c IC50 = 1350 nM PMID: 18553958
CHEMBL489788 antagonist Compound 13 IC50 = 155 nM PMID: 18722119
GR
CHEMBL522432 antagonist Compound 12 IC50 = 440 nM PMID: 18722119 GR
CHEMBL65929 antagonist Compound 18 IC50 = 681 nM PMID: 12781197 GR
CHEMBL97531 agonist Compound 1 Kd = 0.74 +/- 0.14 nM EC50 = 6 nM PMID: 8709117
ZINC03831128 antagonist mifepristone IC50 = 590 nM PMID: 18504132
GR
ZINC03832312 antagonist Compound 5c IC50 = 2050 +/- 800 nM PMID: 10743938 GR
ZINC03832316 antagonist Compound 6k IC50 = 2000 +/- 600 nM PMID: 10743938
GR
ZINC03833821 agonist prednisolone Ki = 37 +/- 12 nM PMID: 11520196 GR
ZINC03833823 agonist desoxycorticosterone Kd = 0.01 PMID: 17132855 GR
ZINC03833824 agonist aldosterone Kd = 0.1 – 0.15 PMID: 17132855 GR
ZINC03833825 antagonist spironolactone IC50 = 14 nM PMID: 17132855 GR
ZINC03927200 antagonist drospirenone PMID: 8922878
GR
ZINC04428529 agonist progesterone Ki < 0.01 nM PMID: 8282004 AR
ZINC04646295 agonist paeoniflorin Kd = 3.5 PMID: 8957748
ZINC12349477 antagonist Compound 4l IC50 = 1386 nM PMID: 12238914 PR
ZINC13490446 antagonist Compound 11j IC50 = 1889 nM PMID: 12781198 GR
ZINC13491407 antagonist Compound 4g IC50 = 839 nM PMID: 12238914 PR
ZINC13491408 antagonist Compound 4h IC50 = 2369 nM PMID: 12238914 PR
ZINC13491410 antagonist Compound 4j IC50 = 2492 nM PMID: 12238914 PR
ZINC13513592 agonist corticosterone Kd = 0.1 – 0.15 PMID: 8070376
ZINC13540519 agonist cortisol Kd = 0.1 – 0.15 PMID: 17132855 AR
ZINC13829445 antagonist RU 26752 PMID: 2333987
ZINC19132424 antagonist E-guggulsterone Ki = 1000 +/- 310 nM IC50 = 1740 +/- 150 nM PMID: 16250653
GR
ZINC19594578 antagonist nifedipine IC50 = 740 nM PMID: 18250364 PXR
ZINC28824240 antagonist Compound (S)-14 Ki = 0.494 nM Kb = 19 nM PMID: 18038968 PR
ZINC28824243 antagonist Compound (R)-14 Ki = 2.25 nM Kb = 66 nM PMID: 18038968 PR
ZINC28824246 antagonist Compound 7 Ki = 7.5 nM Kb = 115 nM PMID: 18038968
ZINC28824247 antagonist Compound 3 Ki = 1.56 nM Kb = 38.2 nM PMID: 18038968
ZINC34891546 antagonist BR-4628 IC50 = 28 nM PMID: 22866979
ZINC36288960 antagonist Compound 1 Ki = 124 nM Kb = 189 nM PMID: 18038968
ZINC38795962 antagonist (+)-mebudipine PMID: 22866979
ZINC38824281 antagonist Compound 1 PMID: 20672822
ZINC3985982 antagonist eplerenone IC50 = 122 nM PMID: 16101407
ZINC40410016 antagonist Compound 17 IC50 = 2300 nM PMID: 18722119 PR
ZINC40937612 antagonist Compound 18 IC50 = 2800 nM PMID: 18722119 PR
ZINC43066029 agonist Compound 22 EC50 = 5.0 nM PMID: 19595590
ZINC43131422 antagonist SM-368229 IC50 = 130 nM PMID: 22866979
ZINC43199512 antagonist Compound 3 IC50 = 16 nM PMID: 22866979
ZINC43200720 antagonist Compound 12 IC50 = 2.4 nM PMID: 22866979
ZINC49070725 antagonist Compound 3 PMID: 20672822
ZINC53195016 antagonist Compound 12 IC50 = 2100 +/- 800 nM PMID: 10743938 GR
ZINC58468427 antagonist Compound cis-27i IC50 = 89 nM PMID: 20672822
ZINC58541427 antagonist Compound (R)-4g IC50 = 101 nM PMID: 20672822
ZINC58563742 antagonist Compound (R)-21a IC50 = 52 nM PMID: 20672822
ZINC58563744 antagonist Compound (R)-12o IC50 = 14 nM PMID: 20672822
ZINC58568397 antagonist Compound cis-27b IC50 = 553 nM PMID: 20672822
ZINC58568502 antagonist Compound cis-27o IC50 = 849 nM PMID: 20672822
ZINC58568873 antagonist Compound (R)-4b IC50 = 41 nM PMID: 20672822
ZINC58568953 antagonist Compound 5 IC50 = 52 nM PMID: 22866979
ZINC58568975 antagonist Compound 4S,5S-23 IC50 = 69 nM PMID: 20672822
ZINC58569034 antagonist Compound cis-27k IC50 = 7 nM PMID: 20672822
ZINC58569035 antagonist Compound cis-27l IC50 = 150 nM PMID: 20672822
ZINC58569241 antagonist Compound trans-27p IC50 = 146 nM PMID: 20672822
ZINC58569251 antagonist Compound (R)-15g IC50 = 16 nM PMID: 20672822
ZINC58569344 antagonist Compound cis-27q IC50 = 39 nM PMID: 20672822
ZINC58575004 antagonist Compound (R)-12p IC50 = 2 nM PMID: 20672822
ZINC58575007 antagonist Compound (R)-22 IC50 = 13 nM PMID: 20672822
ZINC58575322 antagonist Compound cis-27e IC50 = 21 nM PMID: 20672822
ZINC58575990 antagonist Compound cis-27p IC50 = 65 nM PMID: 20672822
ZINC58576098 antagonist Compound cis-27f IC50 = 15 nM PMID: 20672822
ZINC58576175 antagonist Compound 3R,3aR-27c IC50 = 41 nM PMID: 20672822
ZINC58576268 antagonist Compound cis-27g IC50 = 720 nM PMID: 20672822
ZINC58576457 antagonist Compound (R)-4c IC50 = 32 n M PMID: 20672822
ZINC58583488 antagonist Compound (R)-12n IC50 = 26 nM PMID: 20672822
ZINC58583489 antagonist PF-3882845 IC50 = 9 nM PMID: 22866979 PR
ZINC58583655 antagonist Compound cis-27m IC50 = 488 nM PMID: 20672822
ZINC58590675 antagonist Compound cis-27j IC50 = 4 nM PMID: 20672822
ZINC58591058 antagonist Compound (R)-21b IC50 = 6 nM PMID: 20672822
ZINC58592292 antagonist Compound 3S,3aR-29 IC50 = 25 nM PMID: 20672822
ZINC58651263 antagonist Compound (R)-21d IC50 = 135 nM PMID: 20672822
ZINC58655386 antagonist Compound (R)-21c IC50 = 80 nM PMID: 20672822
ZINC62224770 antagonist Compound cis-27h IC50 = 127 nM PMID: 20672822
ZINC68079088 antagonist Compound 29a IC50 = 76 nM (64-90) IC50 = 85 nM (42-170) PMID: 22074142
ZINC72318134 antagonist Compound 8 IC50 = 44 nM PMID: 22866979
ZINC73197627 antagonist Compound 14n IC50 = 41 nM (32-53) IC50 = 43 nM (24-79) PMID: 22074142
ZINC73197628 antagonist Compound 29b IC50 = 12 nM (9.5-15) IC50 = 70 nM (45 -110) PMID: 22074142
ZINC73197629 antagonist Compound 29c IC50 = 21 nM (19-24) IC50 = 15 nM (8.2 -26) PMID: 22074142
ZINC73198000 antagonist Compound 16 PMID: 22866979
ZINC73198784 antagonist Compound 18 PMID: 22866979