| Compound ID |
Pharmacological profile |
Compound name |
Binding data |
Activity data |
Bibliographic ref |
Cross-reactvity |
| CHEMBL2062552 |
agonist |
Compound 5 |
|
EC50 = 55 +/- 3 µM (132%) |
ACS Med. Chem. Lett., 2012, 3, 4, 273 |
|
| CHEMBL2062553 |
agonist |
Compound 6 |
|
EC50 = 22 +/- 1 µM (121%) |
ACS Med. Chem. Lett., 2012, 3, 4, 273 |
|
| CHEMBL2062554 |
agonist |
Compound 7 |
|
EC50 = 11.5 +/- 0.6 µM (210%) |
ACS Med. Chem. Lett., 2012, 3, 4, 273 |
|
| CHEMBL1478 |
agonist |
lithocholic acid |
|
EC50 = 50 µM |
PMID: 10360171 |
|
| CHEMBL51467 |
agonist |
deoxycholic acid |
|
EC50 = 50 µM |
PMID: 10360171 |
|
| ZINC13809556 |
agonist |
Compound 1 |
|
EC50 = 70 +/- 2 nM (60%) |
PMID: 10956205 |
|
| ZINC13809557 |
agonist |
Compound 7 |
|
EC50 = 47 +/- 1 nM (100%) |
PMID: 10956205 |
|
| ZINC13809558 |
agonist |
Compound 10 |
|
EC50 = 100 +/- 10 nM (70%) |
PMID: 10956205 |
|
| ZINC26745705 |
agonist |
Compound 2 |
|
EC50 = 54 +/- 8 nM (130%) |
PMID: 10956205 |
|
| ZINC26745770 |
agonist |
Compound 4 |
|
EC50 = 60 +/- 7 nM (120%) |
PMID: 10956205 |
|
| ZINC26746461 |
agonist |
Compound 5 |
|
EC50 = 12 +/- 1 nM (140%) |
PMID: 10956205 |
|
| ZINC26748330 |
agonist |
Compound 3 |
|
EC50 = 48 +/- 3 nM (160%) |
PMID: 10956205 |
|
| ZINC26816396 |
agonist |
Compound 8 |
|
EC50 = 100 +/- 8 nM (100%) |
PMID: 10956205 |
|
| ZINC26817121 |
agonist |
Compound 9 |
|
EC50 = 37 +/- 5 nM (100%) |
PMID: 10956205 |
|
| CHEMBL292618 |
agonist |
Compound 6c |
|
EC50 = 1.11 +/- 0.13 µM (156 +/- 2%) |
PMID: 12166927 |
|
| CHEMBL298787 |
agonist |
6-ECDCA |
|
EC50 = 0.099 +/- 0.01 µM (144 +/- 5%) |
PMID: 12166927 |
|
| CHEMBL55439 |
agonist |
Compound 6a |
|
EC50 = 0.75 +/- 0.08 µM (148 +/- 3%) |
PMID: 12166927 |
|
| ZINC12502251 |
agonist |
fexaramine |
|
EC50= 25 nM |
PMID: 12718892 |
|
| CHEMBL184469 |
agonist |
Compound 28 |
|
EC50 = 1.22 µM (111%) |
PMID: 15317466 |
|
| CHEMBL185723 |
agonist |
Compound 11 |
|
EC50 = 0.54 µM (105%) |
PMID: 15317466 |
|
| CHEMBL185808 |
agonist |
Compound 16 |
|
EC50 = 1.30 µM (87%) |
PMID: 15317466 |
|
| CHEMBL186340 |
agonist |
Compound 20 |
|
EC50 = 15.62 µM (60%) |
PMID: 15317466 |
|
| CHEMBL186727 |
agonist |
Compound 30 |
|
EC50 = 4.55 µM (68%) |
PMID: 15317466 |
|
| CHEMBL187095 |
agonist |
Compound 23 |
|
EC50 = 2.43 µM (82%) |
PMID: 15317466 |
|
| CHEMBL187204 |
agonist |
Compound 17 |
|
EC50 = 33.18 µM (66%) |
PMID: 15317466 |
|
| CHEMBL187232 |
agonist |
Compound 10 |
|
EC50 = 61.15 µM (68%) |
PMID: 15317466 |
|
| CHEMBL187283 |
agonist |
Compound 26 |
|
EC50 = 9.68 µM (101%) |
PMID: 15317466 |
|
| CHEMBL189246 |
agonist |
Compound 9 |
|
EC50 = 0.48 µM (170%) |
PMID: 15317466 |
|
| CHEMBL189624 |
agonist |
Compound 13 |
|
EC50 = 14.73 µM (113%) |
PMID: 15317466 |
|
| CHEMBL361076 |
agonist |
Compound 14 |
|
EC50 = 15.11 µM (99%) |
PMID: 15317466 |
|
| CHEMBL361464 |
agonist |
Compound 15 |
|
EC50 = 1.21 µM (76%) |
PMID: 15317466 |
|
| CHEMBL426268 |
agonist |
Compound 18 |
|
EC50 = 13.20 µM (58%) |
PMID: 15317466 |
|
| ZINC04096816 |
agonist |
22(R)-hydroxycholesterol |
|
|
PMID: 16371446 |
|
| CHEMBL209146 |
agonist |
DPPF-13 |
|
|
PMID: 16617018 |
|
| ZINC38156691 |
agonist |
DPPF-01 |
|
EC50 = 3.4 µM |
PMID: 16617018 |
|
| CHEMBL210030 |
agonist |
Compound 7d |
|
EC50 = 0.79 µM (62%) |
PMID: 16821780 |
|
| CHEMBL210894 |
agonist |
Compound 7f |
|
EC50 = 7.11 µM (98%) |
PMID: 16821780 |
|
| CHEMBL212641 |
agonist |
Compound 7h |
|
EC50 = 0.59 µM (66%) |
PMID: 16821780 |
|
| CHEMBL212726 |
agonist |
Compound 7e |
|
EC50 = 1.48 µM (106%) |
PMID: 16821780 |
|
| CHEMBL378271 |
agonist |
Compound 7b |
|
EC50 = 1.14 µM (77%) |
PMID: 16821780 |
|
| CHEMBL380156 |
agonist |
Compound 7a |
|
EC50 = 2.50 µM (61%) |
PMID: 16821780 |
|
| CHEMBL438438 |
agonist |
Compound 7g |
|
EC50 = 0.41 µM (63%) |
PMID: 16821780 |
|
| CHEMBL216782 |
antagonist |
Compound 4 |
|
IC50 = 25.3 µM |
PMID: 16905319 |
|
| CHEMBL218308 |
antagonist |
Compound 3 |
|
IC50 = 24.8 µM |
PMID: 16905319 |
|
| CHEMBL219377 |
antagonist |
Compound 2 |
|
IC50 = 64.5 µM |
PMID: 16905319 |
|
| CHEMBL373765 |
antagonist |
Compound 1 |
|
IC50 = 8.1 µM |
PMID: 16905319 |
|
| CHEMBL413656 |
antagonist |
Compound 5 |
|
IC50 = 81.1 µM |
PMID: 16905319 |
|
| ZINC14976971 |
agonist |
Compound 11a |
|
EC50 = 9 µM |
PMID: 17292610 |
|
| ZINC14976974 |
agonist |
Compound 15a |
|
EC50 = 3.0 µM |
PMID: 17292610 |
|
| ZINC14976977 |
agonist |
Compound 15b |
|
EC50 = 3.1 µM |
PMID: 17292610 |
|
| ZINC14976980 |
agonist |
Compound 15c |
|
EC50 = 2.1 µM |
PMID: 17292610 |
|
| ZINC14976983 |
agonist |
Compound 10d |
|
EC50 = 1.3 µM |
PMID: 17292610 |
|
| ZINC14976986 |
antagonist |
Compound 10e |
|
IC50 = 15.8 µM |
PMID: 17292610 |
|
| ZINC14976989 |
agonist |
Compound 15f |
|
EC50 = 1.3 µM |
PMID: 17292610 |
|
| ZINC28816318 |
agonist |
Compound 11b |
|
EC50 = 35.1 µM |
PMID: 17292610 |
|
| ZINC28816330 |
agonist |
Compound 15d |
|
EC50 = 2.5 µM |
PMID: 17292610 |
|
| ZINC28816332 |
agonist |
Compound 15e |
|
EC50 = 0.84 µM |
PMID: 17292610 |
|
| ZINC28816343 |
antagonist |
Compound 10f |
|
IC50 = 22.2 µM |
PMID: 17292610 |
|
| ZINC28816369 |
antagonist |
Compound 10g |
|
IC50 = 33.9 µM |
PMID: 17292610 |
|
| ZINC28816404 |
antagonist |
Compound 15g |
|
IC50 = 4.0 µM |
PMID: 17292610 |
|
| ZINC28816406 |
antagonist |
Compound 15h |
|
IC50 = 3.7 µM |
PMID: 17292610 |
|
| ZINC42852834 |
agonist |
Compound 1c |
|
EC50 = 45 nM (87%) |
PMID: 18621523 |
|
| ZINC42875159 |
agonist |
Compound 1d |
|
EC50 = 500 nM (90%) |
PMID: 18621523 |
|
| CHEMBL483187 |
agonist |
Compound 1u |
|
EC50 = 6.31 µM |
PMID: 18815030 |
|
| CHEMBL483197 |
agonist |
Compound 7 |
|
EC50 = 4.27 µM |
PMID: 18815030 |
|
| CHEMBL483579 |
agonist |
Compound 1n |
|
EC50 = 3.98 µM |
PMID: 18815030 |
|
| CHEMBL484547 |
agonist |
Compound 5b |
|
EC50 = 6.17 µM |
PMID: 18815030 |
|
| CHEMBL485210 |
agonist |
Compound 1a |
|
EC50 = 5.15 µM |
PMID: 18815030 |
|
| CHEMBL485403 |
agonist |
Compound 1c |
|
EC50 = 6.92 µM |
PMID: 18815030 |
|
| CHEMBL485404 |
agonist |
Compound 1d |
|
EC50 = 2.04 µM |
PMID: 18815030 |
|
| CHEMBL485563 |
agonist |
Compound 1t |
|
EC50 = 3.31 µM |
PMID: 18815030 |
|
| CHEMBL519840 |
agonist |
Compound 1b |
|
EC50 = 4.79 µM |
PMID: 18815030 |
|
| CHEMBL519861 |
agonist |
Compound 1f |
|
EC50 = 1.86 µM |
PMID: 18815030 |
|
| CHEMBL520519 |
agonist |
Compound 1e |
|
EC50 = 5.37 µM |
PMID: 18815030 |
|
| CHEMBL520976 |
agonist |
Compound 1j |
|
EC50 = 2.40 µM |
PMID: 18815030 |
|
| CHEMBL410683 |
antagonist |
Z-guggulsterone |
|
antagonist activity = 166 % |
PMID: 19102680 |
|
| CHEMBL518855 |
antagonist |
sarcophine |
|
antagonist activity = 86 % |
PMID: 19102680 |
|
| CHEMBL560225 |
antagonist |
2-epi-16-deoxysarcophine |
|
antagonist activity = 79.5 % |
PMID: 19102680 |
|
| ZINC43070465 |
antagonist |
cembren-1-ol |
|
antagonist activity = 81.7 % |
PMID: 19102680 |
|
| CHEMBL453098 |
agonist |
Compound 6e |
|
EC50 = 73 nM (155%) |
PMID: 19159286 |
|
| CHEMBL453912 |
agonist |
Compound 6g |
|
EC50 = 32 nM (170%) |
PMID: 19159286 |
|
| CHEMBL507745 |
agonist |
Compound 6d |
|
EC50 = 57 nM (160%) |
PMID: 19159286 |
|
| CHEMBL509416 |
agonist |
Compound 6f |
|
EC50 = 60 nM (145%) |
PMID: 19159286 |
|
| ZINC03819618 |
agonist |
Compound 6i |
|
EC50 = 12 nM (144%) |
PMID: 19159286 |
|
| ZINC36409485 |
agonist |
Compound 6h |
|
EC50 = 22 nM (148%) |
PMID: 19159286 |
|
| ZINC36409808 |
agonist |
Compound 6k |
|
EC50 = 29 nM (139%) |
PMID: 19159286 |
|
| ZINC38939746 |
agonist |
Compound 6j |
|
EC50 = 25 nM (190%) |
PMID: 19159286 |
|
| ZINC40379787 |
agonist |
Compound 6b |
|
EC50 = 500 nM (130%) |
PMID: 19159286 |
|
| ZINC40380224 |
agonist |
Compound 6l |
|
EC50 = 8 nM (146%) |
PMID: 19159286 |
|
| ZINC40421371 |
agonist |
Compound 1 |
|
EC50 = 600 nM (100%) |
PMID: 19159286 |
|
| ZINC40848320 |
agonist |
Compound 6m |
|
EC50 = 4 nM (149%) |
PMID: 19159286 |
|
| ZINC40860227 |
agonist |
Compound 6a |
|
EC50 = 500 nM (120%) |
PMID: 19159286 |
|
| ZINC40860229 |
agonist |
Compound 6c |
|
EC50 = 1100 nM (109%) |
PMID: 19159286 |
|
| ZINC01548806 |
agonist |
GW4064 |
IC50 = 0.064 µM |
EC50 = 0.9 µM (100%) |
PMID: 19328688 |
|
| ZINC40876986 |
agonist |
Compound 6b |
IC50 = 0.25 µM |
EC50 = 10 µM (54.3%) |
PMID: 19328688 |
|
| ZINC42852395 |
agonist |
Compound 7c |
IC50 = 1.10-1.13 µM |
EC50 = 5 µM (58.5%) |
PMID: 19328688 |
|
| ZINC44404630 |
agonist |
Compound 6d |
IC50 = 0.69 µM |
EC50 = 9 µM (59.4%) |
PMID: 19328688 |
|
| ZINC44404794 |
agonist |
Compound 7b |
IC50 = 0.045 µM |
EC50 = 0.102 µM (53.7%) |
PMID: 19328688 |
|
| CHEMBL468714 |
agonist |
Compound 1n |
|
EC50 = 72 nM (100%) |
PMID: 19410460 |
|
| ZINC40395281 |
agonist |
Compound 1e |
|
EC50 = 1200 nM (68%) |
PMID: 19410460 |
|
| ZINC40874776 |
agonist |
Compound 1c |
|
EC50 = 230 nM (120%) |
PMID: 19410460 |
|
| ZINC40874778 |
agonist |
Compound 1d |
|
EC50 = 93 nM (110%) |
PMID: 19410460 |
|
| ZINC40879700 |
agonist |
Compound 1g |
|
EC50 = 600 nM (132%) |
PMID: 19410460 |
|
| ZINC42835883 |
agonist |
Compound 1o |
|
EC50 = 390 nM (68%) |
PMID: 19410460 |
|
| ZINC42852245 |
agonist |
Compound 1an |
|
EC50 = 93 nM (105%) |
PMID: 19410460 |
|
| ZINC44388029 |
agonist |
Compound 1am |
|
EC50 = 290 nM (99%) |
PMID: 19410460 |
|
| ZINC44388341 |
agonist |
Compound 1j |
|
EC50 = 89 nM (89%) |
PMID: 19410460 |
|
| ZINC44388344 |
agonist |
Compound 1k |
|
EC50 = 140 nM (70%) |
PMID: 19410460 |
|
| ZINC44388363 |
agonist |
Compound 1ad |
|
EC50 = 200 nM (68%) |
PMID: 19410460 |
|
| ZINC44403921 |
agonist |
Compound 1m |
|
EC50 = 100 nM (86%) |
PMID: 19410460 |
|
| ZINC44404378 |
agonist |
Compound 1ab |
|
EC50 = 540 nM (56%) |
PMID: 19410460 |
|
| ZINC44404382 |
agonist |
Compound 1ac |
|
EC50 = 300 nM (95%) |
PMID: 19410460 |
|
| ZINC44404499 |
agonist |
Compound 1r |
|
EC50 = 1300 nM (53%) |
PMID: 19410460 |
|
| ZINC44404626 |
agonist |
Compound 1s |
|
EC50 = 150 nM (111%) |
PMID: 19410460 |
|
| ZINC44404665 |
agonist |
Compound 1ak |
|
EC50 = 240 nM (75%) |
PMID: 19410460 |
|
| ZINC44404669 |
agonist |
Compound 1al |
|
EC50 = 280 nM (71%) |
PMID: 19410460 |
|
| ZINC44404928 |
agonist |
Compound 1ae |
|
EC50 = 110 nM (66%) |
PMID: 19410460 |
|
| ZINC44405796 |
agonist |
Compound 1f |
|
EC50 = 48 nM (104%) |
PMID: 19410460 |
|
| ZINC44405940 |
agonist |
Compound 1p |
|
EC50 = 82 nM (71%) |
PMID: 19410460 |
|
| ZINC44406403 |
agonist |
Compound 1aj |
|
EC50 = 140 nM (100%) |
PMID: 19410460 |
|
| ZINC44406427 |
agonist |
Compound 1t |
|
EC50 = 56 nM (118%) |
PMID: 19410460 |
|
| ZINC49881460 |
agonist |
Compound 1v |
|
EC50 = 720 nM (112%) |
PMID: 19410460 |
|
| ZINC49881613 |
agonist |
Compound 1u |
|
EC50 = 290 nM
(121%) |
PMID: 19410460 |
|
| ZINC39289518 |
agonist |
Compound 2c |
|
EC50 = 63 nM (93%) |
PMID: 19586769 |
|
| ZINC39289726 |
agonist |
Compound 3a |
|
EC50 = 210 nM (84%) |
PMID: 19586769 |
|
| ZINC43010395 |
agonist |
Compound 3d |
|
EC50 = 1300 nM (63%) |
PMID: 19586769 |
|
| ZINC43013451 |
agonist |
Compound 2d |
|
EC50 = 220 nM (79%) |
PMID: 19586769 |
|
| ZINC43014987 |
agonist |
Compound 2i |
|
EC50 = 1100 nM (61%) |
PMID: 19586769 |
|
| ZINC43023237 |
agonist |
Compound 2l |
|
EC50 = 380 nM (123%) |
PMID: 19586769 |
|
| ZINC43061882 |
agonist |
Compound 2a |
|
EC50 = 32 nM (87%) |
PMID: 19586769 |
|
| ZINC43063208 |
agonist |
Compound 2m |
|
EC50 = 710 nM (75%) |
PMID: 19586769 |
|
| ZINC43065311 |
agonist |
Compound 2e |
|
EC50 = 410 nM (86%) |
PMID: 19586769 |
|
| ZINC43066255 |
agonist |
Compound 2h |
|
EC50 = 980 nM (170%) |
PMID: 19586769 |
|
| ZINC43069532 |
agonist |
Compound 2f |
|
EC50 = 630 nM (103%) |
PMID: 19586769 |
|
| ZINC43071252 |
agonist |
Compound 2b |
|
EC50 = 160 nM (89%) |
PMID: 19586769 |
|
| ZINC43071975 |
agonist |
Compound 2g |
|
EC50 = 130nM (103%) |
PMID: 19586769 |
|
| ZINC43077373 |
agonist |
Compound 3b |
|
EC50 = 330 nM (79%) |
PMID: 19586769 |
|
| ZINC43077789 |
agonist |
Compound 3e |
|
EC50 = 860 nM (63%) |
PMID: 19586769 |
|
| ZINC43120618 |
agonist |
Compound 2j |
|
EC50 = 8300 nM (112%) |
PMID: 19586769 |
|
| CHEMBL565729 |
agonist |
Compound 11c |
|
EC50 = 640 nM (85%) |
PMID: 19683924 |
|
| CHEMBL565752 |
agonist |
Compound 11f |
|
EC50 = 1300 nM (103%) |
PMID: 19683924 |
|
| CHEMBL565981 |
agonist |
Compound 11g |
|
EC50 = 2700 nM (114%) |
PMID: 19683924 |
|
| CHEMBL568014 |
agonist |
Compound 11a |
|
EC50 = 280 nM (115%) |
PMID: 19683924 |
|
| CHEMBL576636 |
agonist |
Compound 11i |
|
EC50 = 3300 nM (112%) |
PMID: 19683924 |
|
| CHEMBL579197 |
agonist |
Compound 11d |
|
EC50 = 1900 nM (127%) |
PMID: 19683924 |
|
| CHEMBL579263 |
agonist |
Compound 11e |
|
EC50 = 5700 nM (91%) |
PMID: 19683924 |
|
| CHEMBL584048 |
agonist |
Compound 11b |
|
EC50 = 1300 nM (84%) |
PMID: 19683924 |
|
| CHEMBL584897 |
agonist |
Compound 11h |
|
EC50 = 4100 nM (115%) |
PMID: 19683924 |
|
| ZINC45245665 |
agonist |
Compound 10a |
|
EC50 = 6.3 nM (121%) |
PMID: 19683924 |
|
| ZINC45257753 |
agonist |
Compound 10d |
|
EC50 = 6.5 nM (124%) |
PMID: 19683924 |
|
| ZINC45286584 |
agonist |
Compound 10e |
|
EC50 = 35 nM (116%) |
PMID: 19683924 |
|
| ZINC45290896 |
agonist |
Compound 10g |
|
EC50 = 8.5 nM (94%) |
PMID: 19683924 |
|
| ZINC45300451 |
agonist |
Compound 10c |
|
EC50 = 5.0 nM (119%) |
PMID: 19683924 |
|
| ZINC45302234 |
agonist |
Compound 10b |
|
EC50 = 2.5 nM (120%) |
PMID: 19683924 |
|
| ZINC45302320 |
agonist |
Compound 10h |
|
EC50 = 16 nM (114%) |
PMID: 19683924 |
|
| ZINC45302321 |
agonist |
Compound 10f |
|
EC50 = 12 nM (122%) |
PMID: 19683924 |
|
| ZINC36410871 |
agonist |
Compound 7 |
|
EC50 = 45 +/- 8 nM (150 +/- 27%) |
PMID: 20095622 |
|
| ZINC44460365 |
agonist |
Compound 14cc |
|
EC50 = 88 +/- 7 nM (219 +/- 40%) |
PMID: 20095622 |
|
| ZINC45367639 |
agonist |
Compound 14x |
|
EC50 = 617 +/- 17 nM (76 +/- 8%) |
PMID: 20095622 |
|
| ZINC45367716 |
agonist |
Compound 14y |
|
EC50 = 1603 +/- 64 nM (70 +/- 18%) |
PMID: 20095622 |
|
| ZINC45368412 |
agonist |
Compound 11g |
|
EC50 = 602 +/- 131 nM (143+/-10%) |
PMID: 20095622 |
|
| ZINC45368417 |
agonist |
Compound 14s |
|
EC50 = 1386 +/- 356 nM (88 +/- 35%) |
PMID: 20095622 |
|
| ZINC45369676 |
agonist |
Compound 11c |
|
EC50 = 534 +/- 131 nM (111 +/- 21%) |
PMID: 20095622 |
|
| ZINC45371148 |
agonist |
Compound 11b |
|
EC50 = 368 +/- 58 nM (75 +/- 4%) |
PMID: 20095622 |
|
| ZINC45372680 |
agonist |
Compound 14t |
|
EC50 = 1317 +/- 343 nM (99 +/- 31%) |
PMID: 20095622 |
|
| ZINC45372684 |
agonist |
Compound 14u |
|
EC50 = 894 +/- 242 nM (98 +/- 22%) |
PMID: 20095622 |
|
| ZINC45373420 |
agonist |
Compound 14l |
|
EC50 = 698 +/- 168 nM (112 +/- 8%) |
PMID: 20095622 |
|
| ZINC45373528 |
agonist |
Compound 11h |
|
EC50 = 342 +/- 93 nM (162 +/- 8%) |
PMID: 20095622 |
|
| ZINC45373665 |
agonist |
Compound 14p |
|
EC50 = 362 +/- 61 nM (103 +/- 3%) |
PMID: 20095622 |
|
| ZINC45384485 |
agonist |
Compound 11e |
|
EC50 = 23 +/- 3 nM (68 +/- 14%) |
PMID: 20095622 |
|
| ZINC45385780 |
agonist |
Compound 14j |
|
EC50 = 1066 +/- 129 nM (140 +/- 11%) |
PMID: 20095622 |
|
| ZINC45386813 |
agonist |
Compound 11d |
|
EC50 = 340 +/- 46 nM (90 +/- 5%) |
PMID: 20095622 |
|
| ZINC45386841 |
agonist |
Compound 14o |
|
EC50 = 271 +/- 20 nM (106 +/- 11%) |
PMID: 20095622 |
|
| ZINC45386986 |
agonist |
Compound 11a |
|
EC50 = 1579 +/- 520 nM (106 +/- 6%) |
PMID: 20095622 |
|
| ZINC45389056 |
agonist |
Compound 14m |
|
EC50 = 249 +/- 70 nM (144 +/- 14%) |
PMID: 20095622 |
|
| ZINC45390278 |
agonist |
Compound 11f |
|
EC50 = 447 +/- 95 nM (149 +/- 5%) |
PMID: 20095622 |
|
| ZINC45392099 |
agonist |
Compound 14k |
|
EC50 = 439 +/- 104 nM (124 +/- 13%) |
PMID: 20095622 |
|
| ZINC45392199 |
agonist |
Compound 14v |
|
EC50 = 855 +/- 220 n M (119 +/- 26%) |
PMID: 20095622 |
|
| ZINC49746667 |
agonist |
Compound 14dd |
|
EC50 = 99 +/- 8 nM (160 +/- 23%) |
PMID: 20095622 |
|
| ZINC49756147 |
agonist |
Compound 14r |
|
EC50 = 194 +/- 17 nM (128 +/- 2%) |
PMID: 20095622 |
|
| ZINC49766388 |
agonist |
Compound 14i |
|
EC50 = 101 +/- 29 nM (156 +/- 12%) |
PMID: 20095622 |
|
| ZINC49766510 |
agonist |
Compound 14w |
|
EC50 = 2870 +/- 23 nM (108 +/- 25%) |
PMID: 20095622 |
|
| ZINC49767149 |
agonist |
Compound 14n |
|
EC50 = 287 +/- 18 nM (125 +/- 11%) |
PMID: 20095622 |
|
| ZINC49767304 |
agonist |
Compound 14z |
|
EC50 = 1121 +/- 76 nM (69 +/- 21%) |
PMID: 20095622 |
|
| ZINC49767456 |
agonist |
Compound 14aa |
|
EC50 = 796 +/- 207 nM (127 +/- 13%) |
PMID: 20095622 |
|
| ZINC49767743 |
agonist |
Compound 14q |
|
EC50 = 424 +/- 72 nM (103 +/- 8%) |
PMID: 20095622 |
|
| ZINC49767834 |
agonist |
Compound 14bb |
|
EC50 = 1023 +/- 69 nM (90 +/- 16%) |
PMID: 20095622 |
|
| CHEMBL1209112 |
agonist |
Compound 16 |
|
EC50 = 40 nM (105%) |
PMID: 20638278 |
|
| CHEMBL1209171 |
agonist |
Compound 20 |
|
EC50 = 48 nM (110%) |
PMID: 20638278 |
|
| CHEMBL1209229 |
agonist |
Compound 33 |
|
EC50 = 101 nM (99%) |
PMID: 20638278 |
|
| CHEMBL1209230 |
agonist |
Compound 34 |
|
EC50 = 179 nM (102%) |
PMID: 20638278 |
|
| CHEMBL1209364 |
agonist |
Compound 38 |
|
EC50 = 155 nM (102%) |
PMID: 20638278 |
|
| CHEMBL1209365 |
agonist |
Compound 39 |
|
EC50 = 352 nM (89%) |
PMID: 20638278 |
|
| ZINC43195963 |
agonist |
Compound 5 |
|
EC50 = 235 nM (101%) |
PMID: 20638278 |
|
| ZINC58468539 |
agonist |
Compound 9 |
|
EC50 = 89 nM (101%) |
PMID: 20638278 |
|
| ZINC58534543 |
agonist |
Compound 11 |
|
EC50 = 225 nM (98%) |
PMID: 20638278 |
|
| ZINC58534789 |
agonist |
Compound 7 |
|
EC50 = 365 nM (95%) |
PMID: 20638278 |
|
| ZINC58538081 |
agonist |
Compound 10 |
|
EC50 = 147 nM (104%) |
PMID: 20638278 |
|
| ZINC58538161 |
agonist |
Compound 27 |
|
EC50 = 242 nM (103%) |
PMID: 20638278 |
|
| ZINC58538443 |
agonist |
Compound 12 |
|
EC50 = 162 nM (97%) |
PMID: 20638278 |
|
| ZINC58540857 |
agonist |
Compound 28 |
|
EC50 = 190 nM (105%) |
PMID: 20638278 |
|
| ZINC58559121 |
agonist |
Compound 22 |
|
EC50 = 12 nM (109%) |
PMID: 20638278 |
|
| ZINC58563831 |
agonist |
Compound 36 |
|
EC50 = 43 nM (98%) |
PMID: 20638278 |
|
| ZINC58563889 |
agonist |
Compound 15 |
|
EC50 = 12 nM (102%) |
PMID: 20638278 |
|
| ZINC58563901 |
agonist |
Compound 13 |
|
EC50 = 22 nM (97%) |
PMID: 20638278 |
|
| ZINC58564033 |
agonist |
Compound 18 |
|
EC50 = 164 nM (87%) |
PMID: 20638278 |
|
| ZINC58564036 |
agonist |
Compound 35 |
|
EC50 = 434 nM (91%) |
PMID: 20638278 |
|
| ZINC58568344 |
agonist |
Compound 19 |
|
EC50 = 3 nM (102%) |
PMID: 20638278 |
|
| ZINC58568459 |
agonist |
Compound 37 |
|
EC50 = 76 nM (86%) |
PMID: 20638278 |
|
| ZINC58575875 |
agonist |
Compound 8 |
|
EC50 = 433 nM (110%) |
PMID: 20638278 |
|
| ZINC58582154 |
agonist |
Compound 14 |
|
EC50 = 17 nM (96%) |
PMID: 20638278 |
|
| ZINC58591476 |
agonist |
Compound 21 |
|
EC50 = 36 nM (114%) |
PMID: 20638278 |
|
| ZINC58598582 |
agonist |
Compound 24 |
|
EC50 = 194 nM (94%) |
PMID: 20638278 |
|
| ZINC58598792 |
agonist |
Compound 17 |
|
EC50 = 35 nM (90%) |
PMID: 20638278 |
|
| ZINC58650353 |
agonist |
Compound 23 |
|
EC50 = 14 nM (105%) |
PMID: 20638278 |
|
| ZINC58650471 |
agonist |
Compound 6 |
|
EC50 = 452 nM (109%) |
PMID: 20638278 |
|
| CHEMBL1668776 |
antagonist |
Compound 4 |
|
IC50 = 5.9 µM |
PMID: 21142112 |
|
| ZINC14691441 |
antagonist |
Compound 5 |
|
IC50 = 9.0 µM |
PMID: 21142112 |
|
| ZINC14691443 |
antagonist |
Compound 6 |
|
IC50 = 17 µM |
PMID: 21142112 |
|
| ZINC66112874 |
antagonist |
Compound 1 |
|
IC50 = 3.9 µM |
PMID: 21142112 |
|
| ZINC66157578 |
antagonist |
Compound 3 |
|
IC50 = 2.5 µM |
PMID: 21142112 |
|
| ZINC66113266 |
antagonist |
Compound 2 |
|
IC50 = 1.5 µM |
PMID: 21142112 |
|
| ZINC39122511 |
agonist |
Compound 1b |
|
EC50 = 68 nM (104%) |
PMID: 21256005 |
|
| ZINC66065898 |
agonist |
Compound 1v |
|
EC50 = 81 nM (93%) |
PMID: 21256005 |
|
| ZINC66066214 |
agonist |
Compound 1r |
|
EC50 = 17 nM (107%) |
PMID: 21256005 |
|
| ZINC66066573 |
agonist |
Compound 1s |
|
EC50 = 14 nM (84%) |
PMID: 21256005 |
|
| ZINC66066574 |
agonist |
Compound 1t |
|
EC50 = 14 nM (103%) |
PMID: 21256005 |
|
| ZINC66066575 |
agonist |
Compound 1u |
|
EC50 = 22 nM (93%) |
PMID: 21256005 |
|
| ZINC66076980 |
agonist |
Compound 1c |
|
EC50 = 50 nM (102%) |
PMID: 21256005 |
|
| ZINC66077321 |
agonist |
Compound 1m |
|
EC50 = 52 nM (91%) |
PMID: 21256005 |
|
| ZINC66077688 |
agonist |
Compound 1d |
|
EC50 = 560 nM (85%) |
PMID: 21256005 |
|
| ZINC66078425 |
agonist |
Compound 1e |
|
EC50 = 260 nM (88%) |
PMID: 21256005 |
|
| ZINC66078427 |
agonist |
Compound 1f |
|
EC50 = 77 nM (86%) |
PMID: 21256005 |
|
| ZINC66078428 |
agonist |
Compound 1g |
|
EC50 = 190 nM (102%) |
PMID: 21256005 |
|
| ZINC66080128 |
agonist |
Compound 1p |
|
EC50 = 24 nM (107%) |
PMID: 21256005 |
|
| ZINC66080131 |
agonist |
Compound 1q |
|
EC50 = 32 nM (109%) |
PMID: 21256005 |
|
| ZINC66112652 |
agonist |
Compound 1k |
|
EC50 = 38 nM (101%) |
PMID: 21256005 |
|
| ZINC66112653 |
agonist |
Compound 1l |
|
EC50 = 110 nM (107%) |
PMID: 21256005 |
|
| ZINC66112891 |
agonist |
Compound 1h |
|
EC50 = 1000 nM (127%) |
PMID: 21256005 |
|
| ZINC66112893 |
agonist |
Compound 1i |
|
EC50 = 690 nM (109%) |
PMID: 21256005 |
|
| ZINC66157567 |
agonist |
Compound 1n |
|
EC50 = 44 nM (94%) |
PMID: 21256005 |
|
| ZINC64744159 |
agonist |
Compound 7i |
IC50 = 0.02 µM |
EC50 = 0.5 µM (51%) |
PMID: 21269824 |
|
| ZINC66099204 |
agonist |
Compound 7h |
IC50 = 0.009 µM |
EC50 = 0.3 µM (54%) |
PMID: 21269824 |
|
| ZINC66099205 |
agonist |
Compound 7j |
IC50 = 0.008 µM |
EC50 = 0.05 µM (59%) |
PMID: 21269824 |
|
| CHEMBL1688117 |
antagonist |
Compound 8 |
|
inhibition = 80 % |
PMID: 21309576 |
|
| ZINC71281670 |
antagonist |
Theonellasterol F |
|
|
PMID: 21428459 |
|
| ZINC71281761 |
antagonist |
Theonellasterol C |
|
|
PMID: 21428459 |
PXR |
| ZINC71282148 |
antagonist |
Theonellasterol E |
|
|
PMID: 21428459 |
PXR |
| ZINC71294190 |
antagonist |
Conicasterol D |
|
|
PMID: 21428459 |
PXR |
| ZINC71294251 |
antagonist |
Conicasterol B |
|
|
PMID: 21428459 |
PXR |
| ZINC71294448 |
antagonist |
Conicasterol C |
|
|
PMID: 21428459 |
PXR |
| ZINC71295392 |
antagonist |
Theonellasterol B |
|
|
PMID: 21428459 |
PXR |
| CHEMBL1765565 |
agonist |
Compound 4 |
|
EC50 = 0.15 +/- 0.05 µM (290%) |
PMID: 21459580 |
|
| CHEMBL240597 |
agonist |
chenodeoxycholic acid |
|
EC50 = 21.0 +/- 3.5 µM (100%) |
PMID: 21459580 |
PXR |
| CHEMBL1834967 |
agonist |
Compound 1e |
|
EC50 = 750 nM (68%) |
PMID: 21890356 |
|
| CHEMBL1835051 |
agonist |
Compound 1o |
|
EC50 = 490 nM (59%) |
PMID: 21890356 |
|
| ZINC72122925 |
agonist |
Compound 1f |
|
EC50 = 24 nM (81%) |
PMID: 21890356 |
|
| ZINC72125848 |
agonist |
Compound 1m |
|
EC50 = 140 nM (69%) |
PMID: 21890356 |
|
| ZINC72125849 |
agonist |
Compound 1n |
|
EC50 = 1700 nM (82%) |
PMID: 21890356 |
|
| ZINC72125912 |
agonist |
Compound 1k |
|
EC50 = 130 nM (90%) |
PMID: 21890356 |
|
| ZINC72125913 |
agonist |
Compound 1l |
|
EC50 = 110 nM (78%) |
PMID: 21890356 |
|
| ZINC72125988 |
agonist |
Compound 1i |
|
EC50 = 990 nM (59%) |
PMID: 21890356 |
|
| ZINC72126044 |
agonist |
Compound 1g |
|
EC50 = 31 nM (85%) |
PMID: 21890356 |
|
| ZINC72126050 |
agonist |
Compound 1j |
|
EC50 = 530 nM (91%) |
PMID: 21890356 |
|
| CHEMBL1097474 |
agonist |
Compound 12 |
|
EC50 = 14.0 µM |
PMID: 22014750 |
|
| CHEMBL1915761 |
agonist |
Compound 14 |
|
EC50 = 5.0 µM |
PMID: 22014750 |
|
| CHEMBL1915763 |
agonist |
Compound 13 |
|
EC50 = 2.5 µM |
PMID: 22014750 |
|
| CHEMBL1917739 |
agonist |
Compound 11 |
|
EC50 = 18.6 µM |
PMID: 22014750 |
|
| CHEMBL434750 |
agonist |
Compound 2 |
|
EC50 = 0.85 µM |
PMID: 22014750 |
|
| ZINC05554770 |
agonist |
Compound 20 |
|
EC50 = 6.17 µM |
PMID: 22018919 |
|
| ZINC17064239 |
agonist |
Compound 19 |
|
EC50 = 3.15 µM |
PMID: 22018919 |
|
| ZINC73385923 |
agonist |
Conicasterol E |
|
|
PMID: 22126372 |
PXR |
| ZINC01658901 |
agonist |
auraptene |
|
|
PMID: 22472691 |
|
| ZINC05158589 |
agonist |
nelumol A |
|
|
PMID: 22472691 |
|
| ZINC38330353 |
agonist |
nelumal A |
|
|
PMID: 22472691 |
|
| CHEMBL2037185 |
agonist |
Compound 7 |
|
EC50 = 10.5 +/- 0.5 µM (63 +/- 9%) |
PMID: 22564381 |
|
| CHEMBL2037187 |
agonist |
Compound 9 |
|
EC50 = 1.1 +/- 0.3 µM (50 +/- 3%) |
PMID: 22564381 |
|
| CHEMBL2037310 |
agonist |
Compound 18 |
|
EC50 = 2.6 +/- 0.4 µM (85 +/- 3%) |
PMID: 22564381 |
|
| CHEMBL2037311 |
agonist |
Compound 19 |
|
EC50 = 1.4 +/- 0.5 µM (68 +/- 4%) |
PMID: 22564381 |
|
| CHEMBL2037313 |
agonist |
Compound 23 |
|
EC50 = 1.3 +/- 0.5 µM (118 +/- 4%) |
PMID: 22564381 |
|
| CHEMBL2037314 |
agonist |
Compound 24 |
|
EC50 = 1.7 +/- 0.4 µM (240 +/- 20%) |
PMID: 22564381 |
|
| CHEMBL2037315 |
agonist |
Compound 25 |
|
EC50 = 1.7 +/- 0.1 µM (120 +/- 2%) |
PMID: 22564381 |
|
| CHEMBL2037316 |
agonist |
Compound 26 |
|
EC50 = 2.2 +/- 0.1 µM (70 +/- 20%) |
PMID: 22564381 |
|
| CHEMBL2037324 |
agonist |
Compound 34 |
|
EC50 = 1.9 +/- 0.1 µM (130 +/- 7%) |
PMID: 22564381 |
|
| CHEMBL2037327 |
agonist |
Compound 37 |
|
EC50 = 1.1 +/- 0.1 µM (190 +/- 10%) |
PMID: 22564381 |
|
| CHEMBL2037328 |
agonist |
Compound 38 |
|
EC50 = 1.1 +/- 0.3 µM (240 +/- 50%) |
PMID: 22564381 |
|
| CHEMBL2037329 |
agonist |
Compound 39 |
|
EC50 = 1.9 +/- 0.1 µM (174 +/- 20%) |
PMID: 22564381 |
|
| CHEMBL2037330 |
agonist |
Compound 40 |
|
EC50 = 2.0 +/- 0.3 µM (50 +/- 3%) |
PMID: 22564381 |
|
| CHEMBL2037331 |
agonist |
Compound 41 |
|
EC50 = 3.9 +/- 0.1 µM (72 +/- 10%) |
PMID: 22564381 |
|
| CHEMBL2037332 |
agonist |
Compound 42 |
|
EC50 = 2.7 +/- 0.2 µM (57 +/- 5%) |
PMID: 22564381 |
|
| CHEMBL2037333 |
agonist |
Compound 43 |
|
EC50 = 1.8 +/- 0.2 µM (84 +/- 6%) |
PMID: 22564381 |
|
| CHEMBL2037334 |
agonist |
Compound 44 |
|
EC50 = 1.3 +/- 0.3 µM (130 +/- 20%) |
PMID: 22564381 |
|
| CHEMBL2059710 |
agonist |
alisol M 23-acetate |
|
RLA = 3.1 |
PMID: 22683342 |
|
| CHEMBL2059711 |
agonist |
alisol A 23-acetate |
|
RLA = 2.7 |
PMID: 22683342 |
|
|
|
|
|
|
|
|