Compound ID Pharmacological profile Compound name Binding data Activity data Bibliographic ref Cross-reactivity
ZINC01490075 agonist Compound (S,S)-2b RBA = 14 +/- 4 % PMID: 10395487 ER_alpha
ZINC13557154 agonist Compound trans-3a RBA = 254 +/- 57 % PMID: 10395487 ER_alpha
ZINC03926298 antagonist fulvestrant IC50 = 7+/-3 nM IC50 = 0.72 +/- 0.2 nM (100%) PMID: 10673099 ER_alpha
ZINC28262868 antagonist Compound 27 RBA = 0.06 % PMID: 11392537
ZINC28264205 antagonist Compound 21 RBA = 10 % PMID: 11392537 ER_alpha
CHEMBL58563 antagonist Compound 4 Ki = 680 +/- 190 nM IC50 = 160 nM PMID: 11459665
CHEMBL132868 agonist Compound 64a RBA = 22 +/- 4 % EC50 = 2.0 nM PMID: 11708925 ER_alpha
CHEMBL133203 agonist Compound 69 RBA = 1.3 % EC50 = 160 nM PMID: 11708925 ER_alpha
CHEMBL134646 agonist Compound 27 RBA = 6.6 +/- 1.9 % EC50 = 8.0 nM PMID: 11708925 ER_alpha
CHEMBL135597 agonist Compound 16h RBA = 18 +/- 3 % EC50 = 1.7 nM PMID: 11708925 ER_alpha
CHEMBL135649 agonist Compound 71 RBA = 2.3 % EC50 = 35 nM PMID: 11708925 ER_alpha
CHEMBL135695 agonist Compound 16g RBA = 60 +/- 11% EC50 = 0.37 nM PMID: 11708925 ER_alpha
CHEMBL136039 agonist Compound 42b RBA = 43 +/- 7 % EC50 = 2.1 nM PMID: 11708925 ER_alpha
CHEMBL334773 agonist DPN RBA = 18 +/- 2 % EC50 = 0.85 nM PMID: 11708925 ER_alpha
CHEMBL334798 agonist Compound 42a RBA = 78 +/- 10% EC50 = 1.4 nM PMID: 11708925 ER_alpha
CHEMBL335412 agonist Compound 66 RBA = 8.3 +/- 1.2 % EC50 = 4.9 nM PMID: 11708925 ER_alpha
CHEMBL335620 agonist Compound 64b RBA = 35 +/- 10 % EC50 = 15 nM PMID: 11708925 ER_alpha
CHEMBL342418 agonist Compound meso-31a RBA = 29 +/- 7 % EC50 = 0.42 nM PMID: 11708925 ER_alpha
ZINC01698387 agonist Compound (E)-37 RBA = 82 +/- 4 % EC50 = 220 nM PMID: 11708925 ER_alpha
ZINC05923210 agonist Compound 29b RBA = 75 +/- 6 % EC50 = 0.15 nM PMID: 11708925 ER_alpha
ZINC13470332 agonist Compound 25 RBA = 2.2 % EC50 = 30 nM PMID: 11708925 ER_alpha
ZINC13470338 agonist Compound dl-31a RBA =2.8 +/- 0.8 % EC50 = 0.41 nM PMID: 11708925 ER_alpha
ZINC13470339 agonist Compound erythro-31b RBA = 3.4 % EC50 = 110 nM PMID: 11708925 ER_alpha
ZINC13470340 agonist Compound 35 RBA = 2.5 +/- 0.7 % EC50 = 21 nM PMID: 11708925 ER_alpha
ZINC13470347 agonist Compound dl-54 RBA = 14 +/- 4% EC50 = 3.7 nM PMID: 11708925 ER_alpha
ZINC13674162 agonist Compound 29a RBA = 48 +/- 3 % EC50 = 0.14 nM PMID: 11708925 ER_alpha
ZINC17327767 agonist Compound (Z)-36 RBA =17 +/- 3 % EC50 = 140 nM PMID: 11708925 ER_alpha
ZINC03581478 agonist Compound 3 EC50 = 114 nM EC50 = 17 nM PMID: 11906280
ZINC13472829 agonist Compound 1 EC50 = 4310 nM EC50 = 166 nM PMID: 11906280
ZINC13472831 agonist Compound 4 EC50 = 115 nM EC50 = 32 nM PMID: 11906280
ZINC13472832 agonist Compound 5 EC50 = 1830 nM EC50 = 302 nM PMID: 11906280
ZINC13472833 agonist Compound 6 EC50 = 4710 nM EC50 = 257 nM PMID: 11906280
ZINC13472834 agonist Compound 7 EC50 = 3940 nM EC50 = 186 nM PMID: 11906280
ZINC13472835 agonist Compound 8 EC50 = 249 nM EC50 = 525 nM PMID: 11906280
ZINC13472836 agonist Compound 9 EC50 = 740 nM EC50 = 245 nM PMID: 11906280
ZINC13472838 agonist Compound 11 EC50 = 129 nM EC50 = 15 nM PMID: 11906280
ZINC13400121 agonist Compound 4 PMID: 12350164 ER_alpha
ZINC14819371 agonist Compound 3 PMID: 12350164 ER_alpha
ZINC14819381 agonist Compound 2 PMID: 12350164 ER_alpha
ZINC01553578 antagonist Compound 15 Ki = 15+/-10 nM IC50 = 6 +/- 2 nM (103 +/- 6%) PMID: 12459017
ZINC13492566 antagonist Compound 21 Ki = 15 +/- 2 nM IC50 = 15 +/- 5 nM (98 +/- 5%) PMID: 12459017
ZINC13492576 antagonist Compound 31 Ki = 40 +/- 15 nM IC50 = 20 +/- 3 nM (93 +/- 2%) PMID: 12459017
ZINC27630210 antagonist Compound 43 Ki = 25 +/ 10 nM IC50 = 5 +/- 2 nM (98 +/- 2%) PMID: 12459017
ZINC27633960 antagonist Compound 17 Ki = 15 +/- 9 nM IC50 = 5 +/- 1 nM (112 +/- 5%) PMID: 12459017
CHEMBL512579 antagonist Compound 1 IC50 = 0.88 +/- 0.004 µM IC50 = 10.5 +/- 5.0 µM PMID: 12502307
CHEMBL296018 antagonist Compound 10 RBA = 35 +/- 7 % PMID: 12699377 ER_alpha
CHEMBL43246 antagonist Compound 9 RBA = 52 +/- 11 % PMID: 12699377
CHEMBL43636 antagonist Compound 11 RBA = 187 +/- 44 % PMID: 12699377
CHEMBL44565 antagonist Compound 32 RBA = 189 +/- 15 % PMID: 12699377
CHEMBL6619 antagonist Compound 36 RBA = 334 +/- 54 % PMID: 12699377
ZINC12353793 antagonist Compound 16 RBA = 211 +/- 57 % PMID: 12699377
ZINC13517894 antagonist Compound 14 RBA = 317 +/- 31 % PMID: 12699377
ZINC13517909 antagonist Compound 8 RBA = 301 +/- 54 % PMID: 12699377
ZINC13517915 antagonist Compound 18 RBA = 125 +/- 22 % PMID: 12699377
ZINC03991700 agonist E15-1,2 (50) RBA = 7 +/- 2 % RSA = 18 +/- 10 % PMID: 12723952 ER_alpha
ZINC13518409 agonist E7α-1,2 (9) RBA = 9 +/- 2 % RSA = 15 +/- 12 % PMID: 12723952 ER_alpha
CHEMBL294889 agonist Compound 2 IC50 = 850 nM %agonist = 149 % PMID: 12749898 ER_alpha
ZINC13490127 agonist Compound 3 IC50 = 75 nM %agonist = 139 % PMID: 12749898 ER_alpha
CHEMBL311878 agonist Compound 6 IC50 = 42 +/- 24 nM EC50 = 18 nM PMID: 12824043
CHEMBL103650 agonist Compound 27 IC50 = 421 +/ 5 nM EC50 = 1 nM PMID: 12825935 ER_alpha
ZINC03831614 agonist alpha-zearalanol EC50 = 24 nM PMID: 12828470
ZINC03831616 agonist beta-zearalanol EC50 = 72 nM PMID: 12828470
ZINC03898789 agonist zearalenone EC50 = 110 nM PMID: 12828470
ZINC04655389 agonist alpha-zearalenol EC50 = 38 nM PMID: 12828470
ZINC04655390 agonist beta-zearalenol EC50 = 220 nM PMID: 12828470
ZINC04655391 agonist zearalanone EC50 = 660 nM PMID: 12828470
ZINC13560486 antagonist Compound 6 IC50 = 2049 nM inhibition = 50% PMID: 15006374 ER_alpha
ZINC29215330 antagonist Compound 11 IC50 = 546 nM inhibition = 46% PMID: 15006374 ER_alpha
CHEMBL264862 agonist Compound 4i IC50 = 310 nM EC50 = 47 nM PMID: 15081034 ER_alpha
CHEMBL306636 agonist Compound 4d IC50 = 320 nM EC50 = 18 nM PMID: 15081034 ER_alpha
CHEMBL74757 agonist Compound 4b IC50 = 330 nM EC50 = 30 nM PMID: 15081034 ER_alpha
CHEMBL74758 agonist Compound 4c IC50 = 200 nM EC50 = 7 nM PMID: 15081034 ER_alpha
CHEMBL77466 agonist Compound 4k IC50 = 1100 nM EC50 = 180 nM PMID: 15081034 ER_alpha
CHEMBL77609 agonist Compound 4n IC50 = 90 nM EC50 = 8 nM PMID: 15081034 ER_alpha
CHEMBL77620 agonist Compound 4m IC50 = 90 nM EC50 = 16 nM PMID: 15081034 ER_alpha
CHEMBL77930 agonist Compound 4j IC50 = 120 nM EC50 = 26 nM PMID: 15081034 ER_alpha
ZINC12353741 agonist Compound 4g IC50 = 1400 nM EC50 = 77 nM PMID: 15081034 ER_alpha
ZINC12353750 agonist Compound 4f IC50 = 2600 nM EC50 = 240 nM PMID: 15081034 ER_alpha
ZINC26392428 agonist Compound 4l IC50 = 1700 nM EC50 = 120 nM PMID: 15081034 ER_alpha
ZINC26399859 agonist Compound 4e IC50 = 5600 nM EC50 = 140 nM PMID: 15081034 ER_alpha
ZINC34801132 agonist Compound 4h IC50 = 2800 nM EC50 = 270 nM PMID: 15081034 ER_alpha
ZINC53151203 agonist Compound 4a IC50 = 2900 nM EC50 = 160 nM PMID: 15081034 ER_alpha
CHEMBL330307 antagonist Compound 11f IC50 = 71.2 nM IC50 = 29.8 nM (66%) PMID: 15125923 ER_alpha
CHEMBL412907 agonist Compound 6c IC50 = 99.0 nM EC50 = 11.1 nM (93%) PMID: 15125923 ER_alpha
CHEMBL89994 antagonist Compound 11c IC50 = 93.3 nM IC50 = 86.6 nM (83%) PMID: 15125923 ER_alpha
CHEMBL93230 antagonist Compound 11i IC50 = 21.3 nM IC50 = 51.3 nM (96%) PMID: 15125923 ER_alpha
ZINC03816519 agonist Compound 2 IC50 = 6 +/- 2 nM % Activity = 126 % PMID: 15341953 ER_alpha
ZINC13520815 agonist 17b-estradiol IC50 = 3.6 +/- 1.6 nM PMID: 15341953 ER_alpha
ZINC16051646 agonist WAY-697 IC50 = 2.2 +/- 1 nM % Activity = 142 % PMID: 15341953 ER_alpha
ZINC16051648 agonist WAY-244 IC50 = 14 +/- 3 nM % Activity = 105 % PMID: 15341953 ER_alpha
ZINC28360400 agonist Compound 9 IC50 = 10 +/- 2 nM PMID: 15341953
ZINC28365864 agonist Compound 10 IC50 = 0.5 +/- 0.2 nM % Activity = 80 % PMID: 15341953
ZINC28365964 agonist Compound 11 IC50 = 3.3 +/- 1.4 nM % Activity = 100 % PMID: 15341953
ZINC28366344 agonist Compound 28 IC50 = 3.2 +/- 0 nM % Activity = 100 % PMID: 15341953
ZINC28367107 agonist Compound 31 IC50 = 1.1 +/- 0 nM % Activity = 90 % PMID: 15341953
ZINC28370566 agonist Compound 20 IC50 = 4.0 +/- 1 nM % Activity = 120 % PMID: 15341953
ZINC28375865 agonist Compound 29 IC50 = 6.6 +/- 2 nM % Activity = 122 % PMID: 15341953
ZINC28388341 agonist Compound 24 IC50 = 7.9 +/- 6 nM % Activity = 113 % PMID: 15341953
ZINC28388344 agonist Compound 27 IC50 = 6.0 +/- 1 nM % Activity = 120 % PMID: 15341953
ZINC28391251 agonist Compound 23 IC50 = 2.0 +/- 1 nM % Activity = 100 % PMID: 15341953
ZINC28391660 agonist Compound 22 IC50 = 10 +/- 3 nM % Activity = 130 % PMID: 15341953
CHEMBL360410 agonist cl-272 IC50 = 3.5 +/- 1.3 nM PMID: 15456246
ZINC13583645 agonist Compound 95 IC50 = 1.4 +/- 0.4 nM % activity = 117 % PMID: 15456246
ZINC03817711 agonist Compound 62 IC50 = 5 +/- 2 nM PMID: 15456246 ER_alpha
ZINC03817763 agonist Erb-041 IC50 (h)= 2.8 +/- 1.5 nM % activity = 120 % PMID: 15456246
ZINC13583638 agonist Compound 91 IC50 (h)= 52 +/- 16 nM % activity = 130 % PMID: 15456246
ZINC13583640 agonist Compound 93 IC50 (h)= 4.4 +/- 2.2 nM % activity = 100 % PMID: 15456246
ZINC13583650 agonist Compound 98 IC50 (h)= 18 +/- 7 nM % activity = 122 % PMID: 15456246
ZINC13583653 agonist Compound 99 IC50 (h)= 2.9 +/- 0.9 nM % activity = 100 % PMID: 15456246
ZINC13583669 agonist Compound 105 IC50 = 190 +/- 88 nM % activity = 83 % PMID: 15456246
ZINC13583673 agonist Compound 108 IC50 = 13 +/- 6 nM % activity = 86 % PMID: 15456246
ZINC13583676 agonist Compound 109 IC50 = 11 +/- 6 nM % activity = 100 % PMID: 15456246
ZINC13583684 agonist Compound 112 IC50 = 15 +/- 3 nM % activity = 117 % PMID: 15456246
ZINC13583689 agonist Compound 114 IC50 = 14 +/- 10 nM % activity = 158 % PMID: 15456246
ZINC13583694 agonist Compound 116 IC50 = 3.5 +/- 1.7 nM % activity = 117 % PMID: 15456246
ZINC13583710 agonist Compound 123 IC50 = 1.9 +/- 0.6 nM % activity = 120 % PMID: 15456246
ZINC13583713 agonist Compound 124 IC50 (h)= 3.1 +/- 1.4 nM % activity = 117 % PMID: 15456246
ZINC13583716 agonist Compound 125 IC50 = 2.2 +/- 1.1 nM % activity = 81 % PMID: 15456246
ZINC28394513 agonist Compound 118 IC50 (h)= 6.3 +/- 1.4 nM % activity = 120 % PMID: 15456246
ZINC28395140 agonist Compound 122 IC50 = 23 +/- 6 nM % activity = 131 % PMID: 15456246
CHEMBL185907 antagonist Compound 21c RBA = 0.10 +/- 0.002 % PMID: 15537344
CHEMBL187972 antagonist Compound 23c RBA = 0.07 +/- 0.01 % PMID: 15537344
CHEMBL191066 antagonist Compound 24b RBA = 0.05 +/- 0.006 % PMID: 15537344
CHEMBL191210 antagonist Compound 25c RBA = 0.07 +/- 0.006 % PMID: 15537344
CHEMBL365110 antagonist Compound 22c RBA = 0.07 +/- 0.01 % PMID: 15537344
CHEMBL426073 antagonist Compound 24c RBA = 1.7 +/- 0.06 % PMID: 15537344
ZINC13584974 antagonist Compound 22a RBA = 0.11 +/- 0.001 % PMID: 15537344
ZINC13607930 agonist Compound 3a EC50 = 3.55 µM (75 %) PMID: 15658860 ER_alpha
ZINC13607934 agonist Compound 3c EC50 = 0.60 µM (60%) PMID: 15658860 ER_alpha
ZINC13607940 agonist Compound 5a EC50 = 0.40 µM (103%) PMID: 15658860 ER_alpha
ZINC00210379 agonist Compound 33 EC50 = 195 nM PMID: 15713407 ER_alpha
ZINC00517292 agonist Compound 31 EC50 = 418 nM PMID: 15713407 ER_alpha
ZINC00519098 agonist Compound 24 EC50 = 38 nM PMID: 15713407 ER_alpha
ZINC28118725 agonist Compound 22 EC50 = 12 nM PMID: 15713407 ER_alpha
ZINC28119115 agonist Compound 29 EC50 = 180 nM PMID: 15713407 ER_alpha
ZINC28119716 agonist Compound 11 EC50 = 197 nM PMID: 15713407 ER_alpha
ZINC28123535 agonist Compound 35 EC50 = 183 nM PMID: 15713407 ER_alpha
ZINC28127517 agonist Compound 20 EC50 = 67 nM PMID: 15713407 ER_alpha
ZINC28127985 agonist Compound 13 EC50 = 485 nM PMID: 15713407 ER_alpha
ZINC28128206 agonist Compound 21 EC50 = 6 nM PMID: 15713407 ER_alpha
ZINC28128361 agonist Compound 36 EC50 = 25 nM PMID: 15713407 ER_alpha
ZINC28128467 agonist Compound 15 EC50 = 79 nM PMID: 15713407 ER_alpha
ZINC28128474 agonist Compound 25 EC50 = 46 nM PMID: 15713407 ER_alpha
ZINC28129275 agonist Compound 37 EC50 = 24 nM PMID: 15713407 ER_alpha
ZINC28129302 agonist Compound 16 EC50 = 275 nM PMID: 15713407 ER_alpha
ZINC28129315 agonist Compound 32 EC50 = 318 nM PMID: 15713407 ER_alpha
ZINC28131038 agonist Compound 17 EC50 = 3164 nM PMID: 15713407 ER_alpha
ZINC28131195 agonist Compound 39 EC50 = 9.2 nM PMID: 15713407 ER_alpha
ZINC28131911 agonist Compound 40 EC50 = 6.0 nM PMID: 15713407 ER_alpha
ZINC28132349 agonist Compound 8 EC50 = 305 nM PMID: 15713407 ER_alpha
ZINC28135139 agonist Compound 19 EC50 = 39 nM PMID: 15713407 ER_alpha
ZINC28135609 agonist Compound 41 EC50 = 1.4 nM PMID: 15713407 ER_alpha
ZINC28135615 agonist Compound 42 EC50 = 7.2 nM PMID: 15713407 ER_alpha
ZINC28136021 agonist Compound 27 EC50 = 40 nM PMID: 15713407 ER_alpha
ZINC28136565 agonist Compound 18 EC50 = 3050 nM PMID: 15713407 ER_alpha
ZINC28136625 agonist Compound 9 EC50 = 2825 nM PMID: 15713407 ER_alpha
CHEMBL178097 agonist Compound 18b RBA = 69 +/- 15 % %efficacy = 78 % PMID: 15715479
CHEMBL178148 agonist Compound 19b RBA = 0.97 +/- 0.21 % %efficacy = 57 % PMID: 15715479
CHEMBL179526 agonist Compound 12e RBA = 18.4 +/- 1.7 % %efficacy = 66 % PMID: 15715479
CHEMBL180071 agonist Compound 12c RBA = 32.1 +/- 9.0 % %efficacy = 88 % PMID: 15715479
CHEMBL180517 agonist Compound 16b RBA = 3.24 +/- 0.92 % %efficacy = 63 % PMID: 15715479
CHEMBL362609 agonist Compound 12f RBA = 8.5 +/- 2.5 % %efficacy = 85 % PMID: 15715479
CHEMBL368225 agonist Compound 21b RBA = 30.1 +/- 6.6 % %efficacy = 82 % PMID: 15715479
CHEMBL1627700 agonist Compound 43 RBA = 240 +/- 130 % 125 +/- 32 % PMID: 15743187
CHEMBL1627711 antagonist Compound 47 RBA = 125 +/- 98 Ki = 0.3 +/- 0.2 nM PMID: 15743187
CHEMBL1627715 antagonist Compound 76 RBA = 82 +/- 16 % Ki = 0.09 +/- 0.06 nM PMID: 15743187
CHEMBL1627717 antagonist Compound 71 RBA = 75 +/- 16 % Ki = 0.3 +/- 0.2 nM PMID: 15743187
CHEMBL1627718 antagonist Compound 60 RBA = 88 +/- 17 % Ki = 0.3 +/- 0.2 nM PMID: 15743187
CHEMBL1627719 antagonist Compound 69 RBA = 111 +/- 23 % Ki = 0.3 +/- 0.2 nM PMID: 15743187
CHEMBL1627720 antagonist Compound 62 RBA = 32 +/- 17 % Ki = 0.4 +/- 0.3 nM PMID: 15743187
CHEMBL1627723 antagonist Compound 58 RBA = 40 +/- 17 % Ki = 0.3 +/- 0.1 nM PMID: 15743187
CHEMBL1628006 antagonist Compound 74 RBA = 93 +/- 18 % Ki = 0.2 +/- 0.2 nM PMID: 15743187
CHEMBL1628013 antagonist Compound 49 RBA = 268 +/- 112 % Ki = 0.1 +/- 0.04 nM PMID: 15743187
ZINC03816518 agonist Way-202196 IC50 = 2.7 +/- 1.9 nM % activity = 120 % PMID: 15943471 ER_alpha
ZINC13645009 agonist Compound 15 IC50 = 2.52 +/- 1.3 nM % activity = 106 % PMID: 15943471 ER_alpha
ZINC13645024 agonist Compound 20 IC50 = 17 +/- 2 nM % activity = 100 % PMID: 15943471
ZINC13645071 agonist Compound 35 IC50 = 4.0 +/- 1 nM % activity = 90 % PMID: 15943471
ZINC13645083 agonist Compound 39 IC50 = 10.6 +/- 0 nM % activity = 100 % PMID: 15943471
ZINC13645093 agonist Compound 42 IC50 = 1.1 +/- 0.5 nM % activity = 88 % PMID: 15943471
ZINC13645096 agonist Compound 43 IC50 = 2.5 +/- 1 nM % activity = 100 % PMID: 15943471
ZINC13645107 agonist Compound 46 IC50 = 2.3 +/- 1.3 nM % activity = 103 % PMID: 15943471
ZINC13645114 agonist Compound 49 IC50 = 6.0 +/- 3.3 nM % activity = 143 % PMID: 15943471
ZINC13645117 agonist Compound 50 IC50 = 11 +/- 6 nM % activity = 100 % PMID: 15943471
CHEMBL306878 agonist NC-1 RBA = 118 % EC50 = 0.30 +/- 0.13 nM (75 +/- 6%) PMID: 16162002 ER_alpha
CHEMBL371192 agonist NC-4 RBA = 0.4 % EC50 = 512 +/- 182 nM (83 +/- 13%) PMID: 16162002 ER_alpha
CHEMBL69408 agonist NC-7 RBA = 8 % EC50 = 52 +/- 18 nM (90 +/- 7%) PMID: 16162002 ER_alpha
ZINC12353813 agonist NC-14 RBA = 5 % EC50 = 37 +/- 9 nM (64 +/- 7%) PMID: 16162002 ER_alpha
ZINC13555419 agonist NC-3 RBA = 1772 % EC50 = 0.30 +/- 0.083 nM (87 +/- 13%) PMID: 16162002 ER_alpha
ZINC13673469 antagonist NC-9 RBA = 4 % Ki = 1.3 +/- 0.4 nM PMID: 16162002
ZINC13673471 antagonist NC-10 RBA = 4 % Ki = 0.19 +/- 0.0 nM PMID: 16162002 ER_alpha
ZINC13673475 antagonist NC-12 RBA = 15 % Ki = 0.49 +/- 0.18 nM PMID: 16162002
ZINC13673477 antagonist NC-13 RBA = 7 % Ki = 1.3 +/- 0.3 nM PMID: 16162002 ER_alpha
ZINC13673479 antagonist NC-15 RBA = 3 % Ki = 0.91 +/- 0.27 nM PMID: 16162002
ZINC13673481 antagonist NC-16 RBA = 7 % Ki = 2.2 +/- 0.73 nM PMID: 16162002
ZINC13673485 antagonist NC-18 RBA = 1 % Ki = 15 +/- 7 nM PMID: 16162002
ZINC13673486 antagonist NC-19 RBA = 18 % Ki = 0.46 +/- 0.16 nM PMID: 16162002 ER_alpha
ZINC13673488 antagonist NC-20 RBA = 1 % Ki =3.8 +/- 1.3  nM PMID: 16162002 ER_alpha
CHEMBL223065 antagonist Compound 12a RBA = 1.7 +/- 0.2  % PMID: 16279785 ER_alpha
CHEMBL389013 antagonist Compound 12b RBA = 0.059 +/- 0.005 % PMID: 16279785 ER_alpha
ZINC03804008 agonist Compound 21 IC50 = 286 nM EC50 = 153 nM PMID: 16309907
ZINC03814414 agonist Compound 22 IC50 = 10 nM EC50 = 6 nM PMID: 16309907
ZINC04081389 agonist Compound 23 IC50 = 1754 nM EC50 = 641 nM PMID: 16309907
ZINC28568286 agonist Compound 7 IC50 = 122 nM EC50 = 68 nM PMID: 16309907
ZINC28568460 agonist Compound 3 IC50 = 11 nM EC50 = 4.1 nM PMID: 16309907 ER_alpha
ZINC28568735 agonist Compound 5 IC50 = 22 nM EC50 = 8.7 nM PMID: 16309907
ZINC28568740 agonist Compound 6 IC50 = 83 nM EC50 = 91 nM PMID: 16309907
ZINC28568760 agonist Compound 4 IC50 = 25 nM EC50 = 3.8 nM PMID: 16309907
ZINC28568788 agonist Compound 20 IC50 = 381 nM EC50 = 171 nM PMID: 16309907
ZINC28568841 agonist Compound 13 IC50 = 96 nM EC50 = 39 nM PMID: 16309907
ZINC28568877 agonist Compound 19 IC50 = 17 nM EC50 = 8 nM PMID: 16309907
ZINC28569026 agonist Compound 16 IC50 = 128 nM EC50 = 148 nM PMID: 16309907
ZINC28569825 agonist Compound 24 IC50 = 230 nM EC50 = 78 nM PMID: 16309907
ZINC28569835 agonist Compound 26 IC50 = 14 nM EC50 = 24 nM PMID: 16309907 ER_alpha
ZINC28569921 agonist Compound 11 IC50 = 1299 nM EC50 = 827 nM PMID: 16309907
ZINC28569925 agonist Compound 12 IC50 = 16 nM EC50 = 21 nM PMID: 16309907 ER_alpha
ZINC28569998 agonist Compound 10 IC50 = 303 nM EC50 = 188 nM PMID: 16309907
ZINC28570424 agonist Compound 28 IC50 = 782 nM EC50 = 379 nM PMID: 16309907
ZINC28570509 agonist Compound 9 IC50 = 210 nM EC50 = 67 nM PMID: 16309907
ZINC28570599 agonist Compound 8 IC50 = 212 nM EC50 = 96 nM PMID: 16309907
ZINC28950313 agonist Compound 25 IC50 = 25 nM EC50 = 31 nM PMID: 16309907
ZINC34633744 agonist Compound 14 IC50 = 361 nM EC50 = 252 nM PMID: 16309907
ZINC12353819 agonist Compound 1aaq IC50 = 30661 nM EC50 = 11685 nM PMID: 16610787
ZINC13685353 agonist Compound 1aa IC50 = 179 nM EC50 = 76 +/- 8 nM PMID: 16610787 ER_alpha
ZINC13685377 agonist Compound 1ag IC50 = 256 nM EC50 = 190 nM PMID: 16610787 ER_alpha
ZINC13685406 agonist Compound 1ao IC50 = 1275 nM EC50 = 8870 nM PMID: 16610787 ER_alpha
ZINC13685409 agonist Compound 1ap IC50 = 3970 nM EC50 = 1638 nM PMID: 16610787
ZINC13685439 agonist Compound 1aab IC50 = 72848 nM EC50 = 3843 nM PMID: 16610787
ZINC13685443 agonist Compound 1aac IC50 = 6994 nM EC50 = 1985 nM PMID: 16610787 ER_alpha
ZINC13685446 agonist Compound 1aad IC50 = 13426 nM EC50 = 8776 nM PMID: 16610787
ZINC13685465 agonist Compound 1aal IC50 = 73677 nM EC50 = 7579 +/- 511 nM PMID: 16610787
ZINC13685468 agonist Compound 1aan IC50 = 265 nM EC50 = 62 nM PMID: 16610787 ER_alpha
ZINC13685476 agonist Compound 1aap IC50 = 9536 nM EC50 = 9406 nM PMID: 16610787
ZINC13685480 agonist Compound 1aar IC50 = 24 nM EC50 = 4457 nM PMID: 16610787
ZINC13685498 agonist Compound 1bd IC50 = 79 nM EC50 = 222 nM PMID: 16610787 ER_alpha
ZINC13685507 agonist Compound 1bf IC50 = 515 nM EC50 = 173 nM PMID: 16610787 ER_alpha
ZINC14972377 agonist Compound 1an IC50 = 12298 nM EC50 = 1966 nM PMID: 16610787
ZINC14972381 agonist Compound 1aam IC50 = 11979 nM EC50 = 3804 nM PMID: 16610787
CHEMBL379109 agonist Compound 28 IC50 = 5.3 nM EC50 = 11 nM PMID: 16632357
CHEMBL209402 agonist Compound 21 IC50 = 1.5 nM EC50 = 4 nM PMID: 16632357
CHEMBL209803 agonist Compound 20 IC50 = 13 nM EC50 = 2 nM PMID: 16632357
CHEMBL378675 agonist Compound 23 IC50 = 3.1 nM EC50 = 5 nM PMID: 16632357
CHEMBL208978 agonist Compound 27 IC50 = 1.5 nM EC50 = 40 nM PMID: 16632357
CHEMBL209851 agonist Compound 19 IC50 = 1.8 nM EC50 = 4 nM PMID: 16632357
CHEMBL379821 agonist Compound 29 IC50 = 1.3 nM EC50 = 2 nM PMID: 16632357
CHEMBL376986 agonist Compound 26 IC50 = 38 nM EC50 = 5 nM PMID: 16632357
CHEMBL381495 agonist Compound 12 IC50 = 16 nM EC50 = 20 nM PMID: 16632357
ZINC04027099 agonist OBCP-3M Ki = 12 nM REP = 3.1 % PMID: 16648639
CHEMBL209650 agonist Compound 24 IC50 = 207 nM EC50 = 210 nM (61%) PMID: 16730987
CHEMBL211870 agonist Compound 34 IC50 = 1.6 nM EC50 = 0.8 nM (81%) PMID: 16730987 ER_alpha
CHEMBL211953 agonist Compound 9 IC50 = 4.0 nM EC50 = 1.7 nM (77%) PMID: 16730987 ER_alpha
CHEMBL377616 agonist Compound 2 IC50 = 618 nM EC50 = 76 nM (84%) PMID: 16730987
CHEMBL379595 agonist Compound 28 IC50 = 8.0 nM EC50 = 1.5 nM (85%) PMID: 16730987
ZINC00003345 agonist Compound 6 IC50 = 4460 nM EC50 = 935 nM (49%) PMID: 16730987
ZINC03943533 agonist Compound 5 IC50 = 7.2 nM EC50 = 2.1 nM (91%) PMID: 16730987 ER_alpha
ZINC34028752 agonist Compound 13 IC50 = 2.2 nM EC50 = 0.7 nM (74%) PMID: 16730987
ZINC34052804 agonist Compound 19 IC50 = 2.8 nM EC50 = 0.6 nM (79%) PMID: 16730987
ZINC34633790 agonist Compound 23 IC50 = 1.4 nM EC50 = 0.8 nM (54%) PMID: 16730987
ZINC34633793 agonist Compound 21 IC50 = 7.7 nM EC50 = 5.8 nM (69%) PMID: 16730987
ZINC34633802 agonist Compound 35 IC50 = 0.3 nM EC50 = 0.2 nM (67%) PMID: 16730987 ER_alpha
ZINC34633805 agonist Compound 11 IC50 = 7.7 nM EC50 = 1.5 nM (70%) PMID: 16730987
ZINC34633808 agonist Compound 17 IC50 = 1.6 nM EC50 = 0.9 nM (76%) PMID: 16730987 ER_alpha
ZINC34633839 agonist Compound 29 IC50 = 1.5 nM EC50 = 0.4 nM (86%) PMID: 16730987 ER_alpha
CHEMBL212392 agonist Compound 26 IC50 = 81 nM EC50 = 17 nM (89%) PMID: 16777408 ER_alpha
CHEMBL213070 agonist Compound 37 IC50 = 43 nM EC50 = 18 nM (82%) PMID: 16777408 ER_alpha
CHEMBL213529 agonist Compound 27 IC50 = 18 nM EC50 = 7.7 nM (90%) PMID: 16777408 ER_alpha
CHEMBL214200 agonist Compound 46 IC50 = 7.4 nM EC50 = 6.5 nM (82%) PMID: 16777408
CHEMBL214693 agonist Compound 1 IC50 = 1.8 nM EC50 = 4 nM (81%) PMID: 16777408 ER_alpha
CHEMBL215802 agonist Compound 38 IC50 = 5.7 nM EC50 = 5.5 nM (85%) PMID: 16777408 ER_alpha
CHEMBL377457 agonist Compound 28 IC50 = 27 nM EC50 = 20 nM (96%) PMID: 16777408
CHEMBL378883 agonist Compound 41 IC50 = 11 nM EC50 = 14 nM (78%) PMID: 16777408 ER_alpha
CHEMBL379314 agonist Compound 24 IC50 = 24 nM EC50 = 20 nM (86%) PMID: 16777408 ER_alpha
CHEMBL380188 agonist Compound 43 IC50 = 58 nM EC50 = 96 nM (77%) PMID: 16777408
CHEMBL384709 agonist Compound 40 IC50 = 3.2 nM EC50 = 2.3 nM (83%) PMID: 16777408 ER_alpha
CHEMBL385028 agonist Compound 36 IC50 = 60 nM EC50 = 46 nM (90%) PMID: 16777408 ER_alpha
CHEMBL438616 agonist Compound 23 IC50 = 3041 nM EC50 = 475 nM(71%) PMID: 16777408
ZINC34003569 agonist Compound 25 S IC50= 5.7 nM EC50 = 5.8 nM (99%) PMID: 16777408 ER_alpha
ZINC34052304 agonist Compound 29 R IC50 = 242 nM EC50 = 28 nM (88%) PMID: 16777408
ZINC34052305 agonist Compound 29 S IC50 = 5.1 nM EC50 = 0.4 nM (91%) PMID: 16777408 ER_alpha
ZINC34633837 agonist Compound 39 S IC50 = 11 nM EC50 = 4.9 nM (76%) PMID: 16777408 ER_alpha
CHEMBL200799 agonist Compound 11 IC50 = 15.1 +/- 3.04 nM EC50 = 6.70 nM (93 %) PMID: 16219463
CHEMBL371012 agonist Compound 14 IC50 = 1.12 +/- 0.73 nM EC50 = 1.09 nM (78 %) PMID: 16219463
ZINC12353762 agonist SERBA-1 Ki = 0.19 +/- 0.01 nM EC50 = 0.66 +/- 0.04 nM (101 +/- 1.3 %) PMID: 17034120 ER_alpha
ZINC14972389 agonist SERBA-2 Ki = 1.54 +/- 0.45 nM EC50 = 3.61 +/- 1.51 nM (100 +/- 10%) PMID: 17034120 ER_alpha
ZINC14814929 agonist Compound 8a IC50 = 863 +/- 292 nM PMID: 17149865 ER_alpha
ZINC14970962 agonist Compound 8b IC50 = 29 +/- 6 nM PMID: 17149865 ER_alpha
ZINC14971010 agonist Compound 8h IC50 = 37 +/- 5 nM PMID: 17149865 ER_alpha
ZINC14971026 agonist Compound 8j IC50 = 244 +/- 40 nM PMID: 17149865 ER_alpha
ZINC13584996 antagonist Compound 2a Ki = 139 nM PMID: 17228884
ZINC13584998 antagonist Compound 3 Ki = 48 nM IC50 = 600 nM PMID: 17228884 ER_alpha
ZINC14970946 antagonist Compound 12a Ki = 71 nM IC50 = 40 nM PMID: 17228884 ER_alpha
ZINC14970950 antagonist Compound 12b Ki = 178 nM IC50 = 250 nM PMID: 17228884 ER_alpha
ZINC28896668 agonist Compound 8 IC50 = 157 nM EC50 = 132 nM PMID: 17448656 ER_alpha
ZINC28896673 agonist Compound 9 IC50 = 322 nM EC50 = 219 nM PMID: 17448656 ER_alpha
ZINC28896830 agonist Compound 11 IC50 = 50 nM EC50 = 28 nM PMID: 17448656
ZINC28896834 agonist Compound 12 IC50 = 854 nM EC50 = 198 nM PMID: 17448656
ZINC28896845 agonist Compound 25 IC50 = 1460 nM EC50 = 86 nM PMID: 17448656
CHEMBL216355 agonist Compound 4b Ki = 0.47 +/- 0.18 nM PMID: 17485205
CHEMBL234460 agonist Compound 4a Ki = 20.8 +/- 4.3 nM PMID: 17485205
CHEMBL234462 agonist Compound 4h Ki = 0.63 +/- 0.46 nM PMID: 17485205
CHEMBL234463 agonist Compound 4d Ki = 0.88 +/- 0.38 nM PMID: 17485205
CHEMBL234633 agonist Compound 4g Ki = 18.5 +/- 7.4 nM PMID: 17485205
CHEMBL234637 agonist Compound 4i Ki = 22.1 +/- 7.3 nM PMID: 17485205
CHEMBL234638 agonist Compound 4c Ki = 0.66 +/- 0.08 nM PMID: 17485205
CHEMBL234639 agonist Compound 4e Ki = 18.9 +/- 1.6 nM PMID: 17485205
CHEMBL397775 agonist Compound 4f Ki = 51 +/- 11 nM PMID: 17485205
CHEMBL239723 agonist Compound 8a IC50 = 0.22 µM EC50 = 0.3 +/- 0.01 µM PMID: 17574424 ER_alpha
CHEMBL239938 agonist Compound 8b IC50 = 0.083 µM EC50 = 0.58 +/- 0.02 µM PMID: 17574424 ER_alpha
CHEMBL391619 agonist Compound 8c IC50 = 0.14 µM EC50 = 4.75 +/- 0.27 µM PMID: 17574424 ER_alpha
CHEMBL392029 agonist Compound 8d IC50 = 0.23 µM EC50 = 6.89 +/- 0.74 µM PMID: 17574424 ER_alpha
CHEMBL235828 agonist Compound 3b Ki = 10.2 nM PMID: 17614275
CHEMBL235829 agonist Compound 2d Ki = 0.70 +/- 0.45 nM PMID: 17614275
CHEMBL236045 agonist Compound 2e Ki = 0.31 +/- 0.19 nM PMID: 17614275
CHEMBL236718 agonist Compound 2b Ki = 0.44 +/- 0.26 nM PMID: 17614275
CHEMBL278936 agonist Compound 2a Ki = 6.92 +/- 0.62 nM PMID: 17614275
CHEMBL391532 agonist Compound 2c Ki = 0.41 +/- 0.07 nM PMID: 17614275
CHEMBL235386 agonist Compound 2c Ki = 0.745 nM PMID: 17662603
CHEMBL236086 agonist Compound 2b Ki = 0.28 +/- 0.02 nM PMID: 17662603
CHEMBL394338 agonist Compound 2d Ki = 5.97 nM PMID: 17662603
CHEMBL399832 agonist Compound 2a Ki = 0.26 +/- 0.091 nM PMID: 17662603
CHEMBL1628029 agonist Compound 2 IC50 = 267 nM PMID: 17696335 ER_alpha
CHEMBL236720 agonist Compound 4a Ki = 0.53 +/- 0.04 nM PMID: 17804226
CHEMBL393390 agonist Compound 4b Ki = 118 nM PMID: 17804226
CHEMBL440283 agonist androstenediol IC50 = 9.9 nM EC50 = 5.6 nM (77%) PMID: 17890084 ER_alpha
ZINC04805059 agonist Compound 14 IC50 = 34 nM EC50 = 210 nM (67%) PMID: 17890084
ZINC04933906 agonist Compound 15 IC50 = 9.4 nM EC50 = 220 nM (59%) PMID: 17890084
ZINC28950302 agonist Compound 4 IC50 = 9 nM EC50 = 69 nM (92%) PMID: 17890084
ZINC28950308 agonist Compound 7 IC50 = 64 nM EC50 = 170 nM (84%) PMID: 17890084
ZINC28950311 agonist Compound 9 IC50 = 72 nM EC50 = 31 nM (80%) PMID: 17890084
ZINC28950315 agonist Compound 13 IC50 = 120 nM EC50 = 230 nM (59%) PMID: 17890084
ZINC40424177 agonist Compound 4f RBA = 0.102 % EC50 = 11 nM (130%) PMID: 18760603 ER_alpha
ZINC40424544 agonist Compound 11b RBA = 1.258 % EC50 = 14 nM (114%) PMID: 18760603 ER_alpha
ZINC40428697 agonist Compound 8 RBA = 0.063 % EC50 = 5.2 nM (240%) PMID: 18760603 ER_alpha
ZINC40952765 agonist Compound 4l RBA = 4.299 % EC50 = 0.59 µM (64%) PMID: 18760603 ER_alpha
ZINC40952767 agonist Compound 4m RBA = 1.912 % EC50 = 0.12 µM (87%) PMID: 18760603 ER_alpha
ZINC40974788 agonist Compound 4i RBA = 0.565 % EC50 = 11 µM (77%) PMID: 18760603 ER_alpha
ZINC40975017 agonist Compound 4j RBA = 18.134 % EC50 = 0.067 µM (85%) PMID: 18760603 ER_alpha
ZINC40975931 agonist Compound 4h RBA = 6.836 % EC50 = 0.5 µM 71%) PMID: 18760603 ER_alpha
ZINC40976496 agonist Compound 12c RBA = 0.004 % EC50 = 12 nM (99%) PMID: 18760603 ER_alpha
ZINC40977295 agonist Compound 4g RBA = 6.696 % EC50 = 0.21 µM (109%) PMID: 18760603 ER_alpha
ZINC40845165 agonist Compound 3 RBA = 7.01 +/- 1.00 % EC50 = 4.8 nM PMID: 19128016 ER_alpha
ZINC40933971 agonist Compound 5 RBA = 2.64 +/- 0.62 % EC50 = 10 nM PMID: 19128016 ER_alpha
ZINC42922029 agonist Compound 32b RBA = 7.5 +/- 1.6 % EC50 = 0.61 nM PMID: 19394116 ER_alpha
ZINC40861576 agonist Compound 9e RBA = 135 % RTA = 146 % PMID: 19167882 ER_alpha
ZINC40862192 agonist Compound 9a RBA = 21.5 % RTA = 164 % PMID: 19167882
ZINC40862503 agonist Compound 9d RBA = 33.6 % RTA = 149 % PMID: 19167882
ZINC40428822 agonist Compound 11b IC50 = 2048 nM PMID: 19356928
ZINC40973106 agonist Compound 13 IC50 = 15030 nM PMID: 19356928
CHEMBL1098709 agonist Compound 3c log IC50 = - 6.496 +/- 0.063 M logEC50 = -7.461 +/- 0.087 M (97.0 +/- 5.0%) PMID: 20408532 ER_alpha
CHEMBL1098710 agonist Compound 3d log IC50 = - 7.271 +/- 0.199 M logEC50 = -7.645 +/- 0.142 M (112 +/- 7.3%) PMID: 20408532 ER_alpha
ZINC49112817 agonist Compound 3f log IC50 = - 7.117 +/- 0.191  M logEC50 = -7.574 +/- 0.108 M (111 +/- 6.4%) PMID: 20408532 ER_alpha
ZINC49115140 agonist Compound 3b log IC50 = -6.596 +/- 0.102 M logEC50 = -6.655 +/- 0.124 M (65.5 +/- 5.8%) PMID: 20408532 ER_alpha
ZINC49781421 agonist Compound 3e log IC50 = - 6.301 +/- 0.078 M logEC50 = -6.616 +/- 0.104 M(108 +/- 5.1%) PMID: 20408532 ER_alpha
ZINC49784137 agonist Compound 3a log IC50 = -5.965 +/- 0.218 M logEC50 = -6.756 +/- 0.081 M (105 +/-5.1%) PMID: 20408532 ER_alpha
CHEMBL1097449 agonist Compound 10ab RBA = 0.16 % Relative activation = 106.7 % PMID: 20430632 ER_alpha
CHEMBL1097457 agonist Compound 30ab RBA = 0.18 % Relative activation = 82.3 % PMID: 20430632 ER_alpha
CHEMBL1099199 agonist Compound 51ab RBA = 0.04 % Relative activation = 103.1 % PMID: 20430632 ER_alpha
ZINC13341109 agonist Compound 1 IC50 = 1.8 +/- 0.3 µM EC50 = 0.53 µM PMID: 20493686 ER_alpha
CHEMBL1082422 agonist Compound 2g EC50 = 4.93 +/- 0.25 µM PMID: 20553023 ER_alpha
CHEMBL1082742 antagonist Compound 3c IC50 = 2.09 +/- 0.39 µM PMID: 20553023 ER_alpha
CHEMBL1083881 agonist Compound 1b EC50 = 4.07 +/- 0.48 µM PMID: 20553023 ER_alpha
CHEMBL1083981 antagonist Compound 3a IC50 = 0.0497 +/- 0.002 µM PMID: 20553023 ER_alpha
ZINC00359736 agonist Compound 2k EC50 = 34.9 +/- 0.76 µM PMID: 20553023 ER_alpha
ZINC00383740 antagonist Compound 3b IC50 = 1.52 +/- 0.55 µM PMID: 20553023 ER_alpha
ZINC00383800 antagonist Compound 3e IC50 = 3.91 +/- 1.24 µM PMID: 20553023 ER_alpha
ZINC00385937 agonist Compound 2j EC50 = 7.06 +/- 0.59 µM PMID: 20553023 ER_alpha
ZINC04167143 agonist Compound 2c EC50 = 0.0498 +/- 0.0018 µM PMID: 20553023 ER_alpha
ZINC04183878 agonist Compound 1a EC50 = 3.91 +/ 0.37 µM PMID: 20553023 ER_alpha
ZINC04473320 agonist Compound 2i EC50 = 5.77 +/- 0.29 µM PMID: 20553023 ER_alpha
ZINC04656499 agonist Compound 2f EC50 = 0.894 +/- 0.14 µM PMID: 20553023 ER_alpha
ZINC04666452 antagonist Compound 3d IC50 = 2.67 +/- 0.33 µM PMID: 20553023 ER_alpha
ZINC05634978 agonist Compound 2h EC50 = 5.36 +/- 0.73 µM PMID: 20553023 ER_alpha
ZINC05730717 agonist Compound 2e EC50 = 0.071 +/- 0.008 µM PMID: 20553023 ER_alpha
ZINC05731164 agonist Compound 2d EC50 = 0.0672 +/- 0.0144 µM PMID: 20553023 ER_alpha
ZINC05731330 agonist Compound 2a EC50 = 0.0338 +/- 0.0048 µM PMID: 20553023 ER_alpha
ZINC06557091 agonist Compound 2b EC50 = 0.0463 +/- 0.0045 µM PMID: 20553023 ER_alpha
ZINC66102047 agonist Compound 1i RBA = 42.8 +/- 5.5 % RTA = 151 +/- 1 % PMID: 21190382
ZINC66102049 agonist Compound 1k RBA = 1.73 +/- 0.2 % RTA = 95.4 +/- 4.0 % PMID: 21190382
ZINC66103290 agonist Compound 1a RBA = 21.5 +/- 4.6 % RTA = 164 +/- 2 % PMID: 21190382
ZINC66103292 agonist Compound 1b RBA = 8.68 +/- 1.7 % RTA = 196 +/- 3 % PMID: 21190382
ZINC66103294 agonist Compound 1c RBA = 136 +/- 7.3 % RTA = 158 +/- 1 % PMID: 21190382
ZINC66103296 agonist Compound 1d RBA = 168 +/- 33 % RTA = 189 +/- 7 % PMID: 21190382 ER_alpha
ZINC66103840 agonist Compound 5 RBA = 118 +/- 4 % RTA = 116.8 +/- 7.8 % PMID: 21190382 ER_alpha
ZINC66111808 agonist Compound 4 RBA = 331 +/- 25 % RTA = 126.7 +/- 7.9 % PMID: 21190382 ER_alpha
ZINC16697226 agonist Compound 18 EC50 = 1.1 +/- 0.3 µM PMID: 21381753
ZINC58651027 agonist Compound 8 EC50 = 0.9 +/- 0.2 µM PMID: 21381753 ER_alpha
ZINC64754982 agonist Compound 10 EC50 = 3.8 +/- 0.7 µM PMID: 21381753 ER_alpha
ZINC64754986 agonist Compound 19 EC50 = 0.6 +/- 0.3 µM PMID: 21381753 ER_alpha
ZINC71315822 agonist Compound 11 EC50 = 1.6 +/- 0.4 µM PMID: 21381753 ER_alpha
ZINC71316870 agonist Compound 14 EC50 = 20 +/- 7 µM PMID: 21381753 ER_alpha
ZINC71316889 agonist Compound 16 EC50 = 30 +/- 17 µM PMID: 21381753 ER_alpha
ZINC71318409 agonist Compound 9 EC50 = 227 +/- 30 µM PMID: 21381753 ER_alpha
ZINC71329506 agonist Compound 12 ZC50 = 3.2 +/- 0.6 µM PMID: 21381753 ER_alpha
ZINC71329876 agonist Compound 15 EC50 = 60 +/- 10 µM PMID: 21381753 ER_alpha
ZINC71296314 agonist Compound 17 EC50 = 1.0 +/- 0.6 µM PMID: 21381753
ZINC29136161 agonist Compound 1c RBA = 4.21 +/- 0.66 % EC50 = 11 nM (60%) PMID: 21481497 ER_alpha
ZINC71282407 agonist Compound 2b RBA = 101 +/- 2 % EC50 = 0.50 nM (80%) PMID: 21481497 ER_alpha
ZINC71294241 agonist Compound 2c RBA = 130 +/- 25 % EC50 = 0.23 nM (100%) PMID: 21481497 ER_alpha
ZINC71294751 agonist Compound 2d RBA = 87.1 +/- 15.0 % EC50 = 1.3 nM (100%) PMID: 21481497 ER_alpha
CHEMBL1836903 agonist Compound 7 EC50 = 1100 nM (49%) PMID: 21885279
CHEMBL1836904 agonist Compound 8 EC50 = 418 nM (44%) PMID: 21885279
CHEMBL1836905 agonist Compound 9 EC50 = 84 nM (<30%) PMID: 21885279
CHEMBL1836909 agonist Compound 13 EC50 = 14 nM (43%) PMID: 21885279
CHEMBL1836910 agonist Compound 14 EC50 = 65 nM (36%) PMID: 21885279
CHEMBL1836911 agonist Compound 15 EC50 = 48 nM (49%) PMID: 21885279
CHEMBL1836912 agonist Compound 16 EC50 = 51 nM (45%) PMID: 21885279 ER_alpha
CHEMBL1836913 agonist Compound 17 EC50 = 1480 nM (86%) PMID: 21885279
CHEMBL1836914 agonist Compound 18 EC50 = 437 nM (82%) PMID: 21885279
ZINC72124547 agonist Compound 4 EC50 = 43 nM (104%) PMID: 21885279 ER_alpha
ZINC72125890 agonist Compound 11 EC50 = 79 nM (48%) PMID: 21885279
ZINC72126103 agonist Compound 12 EC50 = 110 nM (<20%) PMID: 21885279
CHEMBL2031525 agonist Compound 11h RBA = 0.297 +/- 0.08 % EC50 = 760 nM (100 +/- 10%) PMID: 22283328 ER_alpha
CHEMBL2031528 agonist Compound 11k RBA = 0.812 +/- 0.06 % EC50 = 14000 nM (82 +/- 6%) PMID: 22283328 ER_alpha
CHEMBL2031529 agonist Compound 11l RBA = 0.014 +/- 0.004 % EC50 = 800 nM (82 +/- 20%) PMID: 22283328 ER_alpha
CHEMBL2022003 agonist Compound 1 RBA = 0.09 +/- 0002 % EC50 = 0.14 +/- 0.04 µM PMID: 22464681 ER_alpha
CHEMBL2022004 agonist Compound 2 RBA = 0.06 +/- 0.01 EC50 = 0.14 +/- 0.03 µM PMID: 22464681 ER_alpha
CHEMBL2022007 agonist Compound 5 RBA = 0.08 +/- 0.02 % EC50 = 0.32 +/- 0.04 µM PMID: 22464681 ER_alpha
CHEMBL2071176 agonist Compound 2b EC50 = 1.93 +/- 0.048 µM PMID: 22647217 ER_alpha
ZINC00271727 agonist Compound 1h EC50 = 1.46 +/- 0.010 µM PMID: 22647217 ER_alpha
ZINC00365042 agonist Compound 1k EC50 = 13.4 +/- 0.59 µM PMID: 22647217 ER_alpha
ZINC00365043 agonist Compound 2c EC50 = 8.59 +/- 1.0 µM PMID: 22647217 ER_alpha
ZINC00365190 agonist Compound 1j EC50 = 4.95 +/- 0.13 µM PMID: 22647217 ER_alpha
ZINC00365207 agonist Compound 1e EC50 = 0.485 +/- 0.030 µM PMID: 22647217 ER_alpha
ZINC00378186 antagonist Compound 3a IC50 = 0.180 +/- 0.030 µM PMID: 22647217 ER_alpha
ZINC00383745 antagonist Compound 3c IC50 = 2.82 +/- 0.65 µM PMID: 22647217 ER_alpha
ZINC00383772 agonist Compound 1a EC50 = 2.69 +/- 0.25 µM PMID: 22647217 ER_alpha
ZINC00383781 agonist Compound 1c EC50 = 0.185 +/- 0.0006 µM PMID: 22647217 ER_alpha
ZINC00383788 agonist Compound 1f EC50 = 0.823 +/- 0.23 µM PMID: 22647217 ER_alpha
ZINC00482170 agonist Compound 2e EC50 = 28.9 +/- 10 µM PMID: 22647217
ZINC01017110 antagonist Compound 3e IC50 = 8.94 +/- 1.0 µM PMID: 22647217 ER_alpha
ZINC01017164 antagonist Compound 3d IC50 = 4.35 +/- 0.34 µM PMID: 22647217 ER_alpha
ZINC01017209 antagonist Compound 3b IC50 = 1.31 +/- 0.12 µM PMID: 22647217 ER_alpha
ZINC02069659 agonist Compound 1b EC50 = 0.0940 +/- 0.0040 µM PMID: 22647217 ER_alpha
ZINC04666449 agonist Compound 1d EC50 = 0.229 +/- 0.017 µM PMID: 22647217 ER_alpha
ZINC04666501 agonist Compound 1i EC50 = 1.98 +/- 0.38 µM PMID: 22647217 ER_alpha
ZINC04666668 agonist Compound 1g EC50 = 1.01 +/- 0.06 µm PMID: 22647217 ER_alpha
ZINC08722915 agonist Compound 2a EC50 = 0.123 +/- 0.022 µM PMID: 22647217 ER_alpha
ZINC13481431 agonist Compound 2d EC50 = 19.0 +/- 1.1 µM PMID: 22647217 ER_alpha
CHEMBL2178792 agonist Compound 8l RBA = 2.8 % EC50 = 30 nM (88 +/- 14%) PMID: 23043242 ER_alpha
CHEMBL2178793 agonist Compound 8m RBA = 4.1 % EC50 = 23 nM (94 +/- 12%) PMID: 23043242 ER_alpha
CHEMBL2178797 agonist Compound 8b RBA = 3.7 % EC50 = 70 nM (101 +/- 1%) PMID: 23043242 ER_alpha
CHEMBL2179253 agonist Compound 8f RBA = 3.1 % EC50 = 63 nM (92 +/- 10%) PMID: 23043242 ER_alpha
ZINC00001290 agonist diethylstilbestrol Ki = 0.05nM PMID: 9048584
ER_alpha
ZINC00902197 antagonist 4-hydroxytamoxifen Ki = 0.04 nM PMID: 9048584
ZINC03917379 antagonist ICI164,384 Ki = 2.33 nM PMID: 9216828
ZINC03940885 antagonist (R,R) THC Ki = 3.6 nM PMID: 9927308 ER_alpha