| Compound ID |
Pharmacological profile |
Compound name |
Binding data |
Activity data |
Bibliographic ref |
Cross-reactivity |
| ZINC03881635 |
agonist |
ethisterone |
|
|
DrugMatrix |
|
| ZINC05734081 |
agonist |
drq |
|
|
PDB: 2G5O |
|
| CHEMBL385992 |
agonist |
Compound 2d |
Ki = 0.65 nM |
|
PMID: 10229620 |
|
| ZINC01490075 |
agonist |
Compound (S,S)-2b |
RBA = 0.9 +/- 0.2 % |
|
PMID: 10395487 |
ER_beta |
| ZINC03940885 |
agonist |
Compound (R,R)-2b |
RBA = 23 +/- 11 % |
|
PMID: 10395487 |
ER_beta |
| ZINC12832812 |
agonist |
Compound trans-3b |
RBA = 221 +/- 42 % |
|
PMID: 10395487 |
|
| ZINC13557154 |
agonist |
Compound trans-3a |
RBA = 222 +/- 18 % |
|
PMID: 10395487 |
ER_beta |
| ZINC13557156 |
agonist |
Compound (R,R)-2a |
RBA = 24 +/- 6 % |
|
PMID: 10395487 |
|
| ZINC13557160 |
agonist |
Compound (R,R)-2c |
RBA = 5.2 +/- 1.0 % |
|
PMID: 10395487 |
|
| ZINC13557162 |
agonist |
Compound (S,S)-2c |
RBA = 1.6 +/- 0.4 % |
|
PMID: 10395487 |
|
| ZINC00538602 |
antagonist |
Compound 8 |
IC50 = 1440 nM (RBA=0.4) |
IC50 = 1040 nM |
PMID: 10447957 |
|
| ZINC13799676 |
antagonist |
Compound 12 |
IC50 = 1700 nM (RBA=0.35) |
IC50 = 720 nM |
PMID: 10447957 |
|
| ZINC13799678 |
antagonist |
Compound 13 |
IC50 = 235 nM (RBA=2.5) |
IC50 = 20 nM |
PMID: 10447957 |
|
| ZINC13799681 |
antagonist |
Compound 14 |
IC50 = 6000 nM (RBA=0.1) |
IC50 = 3200 nM |
PMID: 10447957 |
|
| CHEMBL1627353 |
agonist |
Compound 20 |
IC50 = 397 +/- 143 nM |
EC50 = 7 +/- 1 nM (Eff=78%) |
PMID: 10673099 |
|
| CHEMBL1627354 |
antagonist |
Compound 12 |
IC50 = 9 +/- 4 nM |
IC50 = 3.5 +/- 2 nM (Eff=99%) |
PMID: 10673099 |
|
| CHEMBL1627356 |
agonist |
Compound 11 |
IC50 = 94 +/- 55 nM |
EC50 = 173 +/- 6 nM (Eff=104%) |
PMID: 10673099 |
|
| CHEMBL1628170 |
agonist |
Compound 10 |
IC50 = 46 +/- 23 nM |
EC50 = 13 +/- 1 nM (Eff=104%) |
PMID: 10673099 |
|
| ZINC01895310 |
antagonist |
Compound 7a |
IC50 = 39 nM |
IC50 = 654 nM |
PMID: 10673099 |
|
| ZINC03926298 |
antagonist |
fulvestrant |
IC50 = 6 +/- 1nM |
IC50 = 0.47 +/- 0.2 nM (Eff=100%) |
PMID: 10673099 |
ER_beta |
| CHEMBL14702 |
agonist |
3-3'-dihydroxyhexestrol |
IC50 = 5.85 +/- 1.65 nM |
|
PMID: 10746941 |
|
| CHEMBL316048 |
agonist |
5α-Androstane-3β,17β-diol |
IC50 = 0.75 +/- 0.13 µM |
|
PMID: 10746941 |
|
| ZINC00001306 |
agonist |
dimethylstilbestrol (DMS) |
IC50 = 6.2 +/- 1.3 nM |
|
PMID: 10746941 |
|
| ZINC01566834 |
agonist |
hexestrol monomethylether |
IC50 = 9.6 +/- 1.4 nM |
|
PMID: 10746941 |
|
| ZINC01747889 |
agonist |
DES monomethyl ether |
IC50 = 4.4 +/- 0.5 nM |
|
PMID: 10746941 |
|
| ZINC02048444 |
agonist |
p-(α,β-Diethyl-p-methyl phenethyl)-meso phenol a |
IC50 = 22.5 +/- 7.5 nM |
|
PMID: 10746941 |
|
| ZINC02106113 |
agonist |
norethynodrel |
IC50 = 0.4 +/- 0.01 µM |
|
PMID: 10746941 |
|
| ZINC03814416 |
agonist |
3-deoxyy-estradiol |
IC50 = 0.18 +/- 0.02 µM |
|
PMID: 10746941 |
|
| ZINC03815418 |
agonist |
estriol |
IC50 = 9.25 +/- 1.75 nM |
|
PMID: 10746941 |
|
| ZINC03815424 |
agonist |
mestranol |
IC50 = 39.7 +/- 6.5 nM |
|
PMID: 10746941 |
|
| ZINC03815431 |
agonist |
estra-1,3,5(10)-trien-13-one-3-ol |
IC50 = 0.175 +/- 0.005µM |
|
PMID: 10746941 |
|
| ZINC38664631 |
agonist |
dienestrol |
IC50 = 2.4 +/- 0.5 nM |
|
PMID: 10746941 |
|
| ZINC03812897 |
agonist |
ethinylestradiol |
IC50 = 0.473 +/- 0.6 nM |
EC50 = 0.06 nM |
PMID: 10746941 PMID: 9658195 |
|
| ZINC00283101 |
agonist |
HPTE |
|
EC50 = 51 nM |
PMID: 10999957 |
|
| ZINC03815443 |
agonist |
Compound 4b |
RBA = 31 +/- 15 % |
EC50 = 1 nM |
PMID: 11150164 |
|
| ZINC13121898 |
agonist |
Compound 4g |
RBA = 49 +/- 12 % |
|
PMID: 11150164 |
|
| ZINC13558363 |
agonist |
Compound 4c |
RBA = 16.8 +/- 0.3 % |
|
PMID: 11150164 |
|
| ZINC01666991 |
agonist |
2,6-dimethylhexestrol |
logRBA = 1.11 |
|
PMID: 11206373 |
|
| ZINC02035359 |
agonist |
α,α,dimethylethyl
allenolic acid |
logRBA = -0.02 |
|
PMID: 11206373 |
|
| ZINC01631270 |
agonist |
4-Ethyl-7-hydroxy-3-(p-methoxyphenyl)coumarin |
RBA = 0.90 % |
|
PMID: 11258977 |
|
| ZINC03815427 |
agonist |
17-deoxyestradiol |
RBA = 14.1 % |
|
PMID: 11258977 |
|
| ZINC03815432 |
agonist |
6-α-hydroxyestradiol |
RBA = 0.71 % |
|
PMID: 11258977 |
|
| ZINC00602799 |
antagonist |
ERA-923 |
IC50 = 14 +/- 10 nM |
IC50 = 1.5 +/- 0.4 nM |
PMID: 11356100 |
|
| ZINC01895505 |
antagonist |
TSE-424 |
IC50 = 23 +/- 15 nM |
IC50 = 3.7 +/- 1.6 nM |
PMID: 11356100 |
|
| ZINC01914469 |
antagonist |
ZK119010 |
IC50 = 25 +/- 13 nM |
IC50 = 69 +/- 23 nM |
PMID: 11356100 |
|
| ZINC28264205 |
antagonist |
Compound 21 |
RBA = 38 % |
|
PMID: 11392537 |
ER_beta |
| CHEMBL289277 |
agonist |
Emodin |
Ki = 0.77 µM |
|
PMID: 11459643 |
|
| CHEMBL298398 |
agonist |
2,6-dihydroxyanthraquinone |
Ki = 0.31 µM |
|
PMID: 11459643 |
|
| CHEMBL464360 |
agonist |
Emodin-8-O-β-δ-glucopyranoside |
Ki = 5.7 µM |
|
PMID: 11459643 |
|
| ZINC26508340 |
antagonist |
Compound 9a |
RBA = 32 +/- 9 % |
|
PMID: 11549460 |
|
| ZINC26568780 |
antagonist |
Compound 9b |
RBA = 75 +/- 20 % |
IC50 = 65 nM |
PMID: 11549460 |
|
| ZINC26572661 |
antagonist |
Compound 9c |
RBA = 34 +/- 2 % |
|
PMID: 11549460 |
|
| ZINC13558564 |
agonist |
Compound 15a |
RBA = 40 +/- 6.5 % |
|
PMID: 11689070 |
|
| ZINC13558565 |
agonist |
Compound 15b |
RBA = 140 +/- 38 % |
|
PMID: 11689070 |
|
| ZINC13558566 |
agonist |
Compound 15c |
RBA = 100 +/- 14 % |
|
PMID: 11689070 |
|
| ZINC13558570 |
agonist |
Compound 15g |
RBA = 140 +/- 13 % |
|
PMID: 11689070 |
|
| CHEMBL132868 |
agonist |
Compound 64a |
RBA = 0.71 +/- 0.12 % |
EC50 = 2.9 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL133203 |
agonist |
Compound 69 |
RBA = 0.11 % |
EC50 = 464 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL134646 |
agonist |
Compound 27 |
RBA = 0.22 +/- 0.06 % |
EC50 = 23 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL135597 |
agonist |
Compound 16h |
RBA = 0.41 +/- 0.21 % |
EC50 = 16 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL135649 |
agonist |
Compound 71 |
RBA = 0.24 % |
EC50 = 18 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL135695 |
agonist |
Compound 16g |
RBA = 0.87 +/- 0.18 % |
EC50 = 6.7 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL136039 |
agonist |
Compound 42b |
RBA = 3.8 +/- 0.6 % |
EC50 = 0.38 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL334773 |
agonist |
DPN |
RBA = 0.25 +/- 0.15 % |
EC50 = 66 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL334798 |
agonist |
Compound 42a |
RBA = 3.3 +/- 0.9 % |
EC50 = 3.1 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL335412 |
agonist |
Compound 66 |
RBA = 0.76 +/- 0.18 % |
EC50 = 2.7 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL335620 |
agonist |
Compound 64b |
RBA = 10 +/- 2 % |
EC50 = 42 nM |
PMID: 11708925 |
ER_beta |
| CHEMBL342418 |
agonist |
Compound meso-31a |
RBA = 0.55 +/- 0.07 % |
EC50 = 18 nM |
PMID: 11708925 |
ER_beta |
| ZINC01698387 |
agonist |
Compound (E)-37 |
RBA = 9.8 +/- 0.4 % |
EC50 = 400 nM |
PMID: 11708925 |
ER_beta |
| ZINC05923210 |
agonist |
Compound 29b |
RBA = 17 +/- 5 % |
EC50 = 0.064 nM |
PMID: 11708925 |
ER_beta |
| ZINC13470332 |
agonist |
Compound 25 |
RBA = 0.16 +/- 0.01 % |
EC50 = 130 nM |
PMID: 11708925 |
ER_beta |
| ZINC13470338 |
agonist |
Compound dl-31a |
RBA = 0.04 +/- 0.01 % |
EC50 = 14 nM |
PMID: 11708925 |
ER_beta |
| ZINC13470339 |
agonist |
Compound erythro-31b |
RBA = 0.063 % |
EC50 = 150 nM |
PMID: 11708925 |
ER_beta |
| ZINC13470340 |
agonist |
Compound 35 |
RBA = 0.29 +/- 0.04 % |
EC50 = 40 nM |
PMID: 11708925 |
ER_beta |
| ZINC13470347 |
agonist |
Compound dl-54 |
RBA = 0.48 +/- 0.07 % |
EC50 = 73 nM |
PMID: 11708925 |
ER_beta |
| ZINC13674162 |
agonist |
Compound 29a |
RBA = 1.7 +/- 0.3 % |
EC50 = 5.2 nM |
PMID: 11708925 |
ER_beta |
| ZINC17327767 |
agonist |
Compound (Z)-36 |
RBA = 0.30 +/- 0.06 % |
EC50 = 95 nM |
PMID: 11708925 |
ER_beta |
| ZINC03815417 |
agonist |
moxestrol |
IC50 = 2.9 +/- 1.7 nM |
EC50 = 0.08 +/- 0.01 nM (Emax=100%) |
PMID: 11738564 |
|
| ZINC00001290 |
agonist |
Diethylstilbestrol (DES) |
EC50 = 12 nM |
EC50 = 0.06 nM |
PMID: 11906280 |
ER_beta |
| ZINC03815415 |
agonist |
17-α-estradiol |
EC50 = 570 nM |
EC50 = 1.5 nM |
PMID: 11906280 |
|
| ZINC13509425 |
agonist |
estrone |
EC50 = 480 nM |
EC50 = 0.7 nM |
PMID: 11906280 |
|
| ZINC13520815 |
agonist |
estradiol |
EC50 = 24 nM |
EC50 = 0.02 nM |
PMID: 11906280 |
ER_beta |
| ZINC18825330 |
agonist |
genistein |
EC50 = 3920 nM |
EC50 = 48 nM |
|
ERR_alpha |
| ZINC22925798 |
agonist |
Compound 6 |
RBA = 0.05 % |
Relative activation = 73 % |
PMID: 12014971 |
|
| ZINC40810574 |
agonist |
Compound 8 |
RBA = 0.42 % |
Relative activation = 74 % |
PMID: 12014971 |
|
| ZINC13400121 |
agonist |
Compound 4 |
|
|
PMID: 12350164 |
ER_beta |
| ZINC14819371 |
agonist |
Compound 3 |
|
|
PMID: 12350164 |
ER_beta |
| ZINC14819381 |
agonist |
Compound 2 |
|
|
PMID: 12350164 |
ER_beta |
| ZINC13492382 |
antagonist |
Compound 3d |
RBA = 5.95 % |
IC50 = 9 nM |
PMID: 12431063 |
|
| ZINC13492383 |
antagonist |
Compound 3e |
RBA = 2.09 % |
IC50 = 50 nM |
PMID: 12431063 |
|
| ZINC13492384 |
antagonist |
Compound 3f |
RBA = 0.62 % |
IC50 =500 nM |
PMID: 12431063 |
|
| CHEMBL30996 |
antagonist |
Compound 16 |
Ki = 8.69 +/- 0.33 nM |
|
PMID: 12672240 |
|
| CHEMBL31089 |
antagonist |
Compound 15 |
Ki = 120 +/- 54 nM |
|
PMID: 12672240 |
|
| ZINC13494068 |
antagonist |
Compound 12c |
Ki = 490 +/- 130 nM |
|
PMID: 12672240 |
|
| ZINC13494069 |
antagonist |
Compound 14b |
Ki = 290 +/- 60 nM |
|
PMID: 12672240 |
|
| ZINC13494070 |
antagonist |
Compound 14c |
Ki = 210 +/- 60 nM |
|
PMID: 12672240 |
|
| ZINC13494224 |
antagonist |
Compound 3d |
RBA = 4.03 % |
IC50 = 70 nM |
PMID: 12672249 |
|
| ZINC13494225 |
antagonist |
Compound 3e |
RBA = 0.95 % |
IC50 = 240 nM |
PMID: 12672249 |
|
| CHEMBL296018 |
agonist |
Compound 10 |
RBA = 31 +/- 3 % |
|
PMID: 12699377 |
ER_beta |
| ZINC03991700 |
agonist |
E15-1,2 |
RBA = 22 +/- 5 % |
RSA = 18 +/- 10 % |
PMID: 12723952 |
ER_beta |
| ZINC03991701 |
agonist |
E15-1,1 |
RBA = 20 +/- 10 % |
RSA = 11 +/- 5 % |
PMID: 12723952 |
|
| ZINC13518406 |
agonist |
E7α-1,1 |
RBA = 12 +/- 4 % |
RSA = 40 +/- 25 % |
PMID: 12723952 |
|
| ZINC13518409 |
agonist |
E7α-1,2 |
RBA = 11 +/- 2 % |
RSA = 15 +/- 12 % |
PMID: 12723952 |
ER_beta |
| ZINC13518413 |
agonist |
E7α-1,2F1 |
RBA = 3 +/- 0.3 % |
RSA = 2 +/- 1 % |
PMID: 12723952 |
|
| ZINC13518417 |
agonist |
E7α-1,3i |
RBA = 4 +/- 1 % |
RSA = 1 +/- 0.7 % |
PMID: 12723952 |
|
| ZINC13518421 |
agonist |
E7α-1,4 |
RBA = 9 +/- 2 % |
RSA = 0.6 +/- 0.3 % |
PMID: 12723952 |
|
| ZINC13518428 |
agonist |
E7α-2,1 |
RBA = 3 +/- 0.8 % |
RSA = 0.8 +/- 0.3 % |
PMID: 12723952 |
|
| ZINC13518432 |
agonist |
E7α-2,2 |
RBA = 1 +/- 0.2 % |
RSA = 0.2 +/- 0.03 % |
PMID: 12723952 |
|
| ZINC13518446 |
agonist |
E11-2,0 |
RBA = 0.3 +/- 0.2 % |
RSA = 0.3 +/- 0.3 % |
PMID: 12723952 |
|
| ZINC13518450 |
agonist |
E11-2,1 |
RBA = 24 +/- 8 % |
RSA = 16 +/- 10 % |
PMID: 12723952 |
|
| ZINC13518480 |
agonist |
E15-1,2F1 |
RBA = 8 +/- 3 % |
RSA = 3 +/- 0.2 % |
PMID: 12723952 |
|
| ZINC13518484 |
agonist |
E15-1,3 |
RBA = 17 +/- 5 % |
RSA = 2 +/- 1 % |
PMID: 12723952 |
|
| ZINC13518488 |
agonist |
E15-1,3i |
RBA = 5 +/- 4 % |
RSA = 0.3 +/- 0.06 % |
PMID: 12723952 |
|
| ZINC13518491 |
agonist |
E15-1,4 |
RBA = 8 +/- 2 % |
RSA = 0.7 +/- 0.4 % |
PMID: 12723952 |
|
| ZINC13518498 |
agonist |
E15-2,1 |
RBA = 5 +/- 3 % |
RSA = 1 +/- 1 % |
PMID: 12723952 |
|
| ZINC13518502 |
agonist |
E15-2,2 |
RBA = 2 +/- 0 % |
RSA = 0.4 +/- 0.5 % |
PMID: 12723952 |
|
| ZINC66058841 |
agonist |
E7β-1,2 |
RBA = 0.4 +/- 0.4 % |
RSA = 0.4 +/- 0.3 % |
PMID: 12723952 |
|
| ZINC66065850 |
agonist |
E7β-1,1 |
RBA = 0.1 +/- 0.1 % |
RSA = 0.4 +/-
0.1 % |
PMID: 12723952 |
|
| CHEMBL293297 |
antagonist |
Compound 13 |
Ki = 2.5 nM |
IC50 = 590 nM |
PMID: 12749895 |
|
| CHEMBL293599 |
agonist |
Compound 5 |
Ki = 170 nM |
|
PMID: 12749895 |
|
| CHEMBL56166 |
antagonist |
Compound 7c |
Ki = 88 nM |
IC50 = 990 nM |
PMID: 12749895 |
|
| CHEMBL56198 |
antagonist |
Compound 8c |
Ki = 0.6 nM |
IC50 = 270 nM |
PMID: 12749895 |
|
| CHEMBL56306 |
antagonist |
Compound 10 |
Ki = 1.1 nM |
IC50 = 68 nM |
PMID: 12749895 |
|
| CHEMBL56390 |
antagonist |
Compound 12 |
Ki = 0.9 nM |
IC50 = 490 nM |
PMID: 12749895 |
|
| CHEMBL58688 |
antagonist |
Compound 8b |
Ki = 0.6 nM |
IC50 = 390 nM |
PMID: 12749895 |
|
| CHEMBL59146 |
antagonist |
Compound 7a |
Ki = 29 nM |
IC50 = 620 nM |
PMID: 12749895 |
|
| CHEMBL59311 |
antagonist |
Compound 7b |
Ki = 37 nM |
IC50 = 590 nM |
PMID: 12749895 |
|
| CHEMBL60538 |
antagonist |
Compound 8a |
Ki = 1.7 nM |
IC50 = 490 nM |
PMID: 12749895 |
|
| ZINC01530090 |
antagonist |
4-hydroxytamoxifene |
Ki = 0.5 nM |
IC50 = 2.6 nM |
PMID: 12749895 |
|
| ZINC13490103 |
agonist |
Compound 3 |
Ki = 310 nM |
|
PMID: 12749895 |
|
| CHEMBL294889 |
agonist |
Compound 2 |
IC50 = 3200 nM |
EC50=20 nM (%agonist = 149 %) |
PMID: 12749898 |
ER_beta |
| ZINC13490127 |
agonist |
Compound 3 |
IC50 = 550 nM |
EC50 <10 nM (%agonist = 139 %) |
PMID: 12749898 |
ER_beta |
| CHEMBL103650 |
agonist |
Compound 27 |
IC50 = 285 +/ 34 nM |
EC50 = 1 nM (Eff=100 +/- 11%) |
PMID: 12825935 |
ER_beta |
| ZINC13526878 |
agonist |
Compound 4 |
RBA = 0.15 +/- 0.05 % |
|
PMID: 12954056 |
|
| CHEMBL148862 |
agonist |
Compound 3j |
|
ED50 = 0.10 µM |
PMID: 14584960 |
|
| ZINC12353746 |
agonist |
Compound 3e |
|
ED50 = 0.9 µM |
PMID: 14584960 |
|
| ZINC12353777 |
agonist |
Compound 3h |
|
ED50 = 1.5 µM |
PMID: 14584960 |
|
| ZINC13529647 |
agonist |
Compound 3f |
|
ED50 = 0.8 µM |
PMID: 14584960 |
|
| ZINC13529653 |
agonist |
Compound 3i |
|
ED50 = 0.21 µM |
PMID: 14584960 |
|
| ZINC13475118 |
agonist |
Compound 3b |
RBA < 0.1 % |
EC50 = 0.380 µM |
PMID: 14761193 |
|
| ZINC13475121 |
agonist |
Compound 3c |
RBA < 0.1 % |
EC50 = 0.065 µM |
PMID: 14761193 |
|
| ZINC13559437 |
agonist |
Compound 5c |
RBA < 0.1 % |
EC50 = 5 µM |
PMID: 14761193 |
|
| ZINC13559438 |
agonist |
Compound 7a |
RBA < 0.1 % |
EC50 = 0.300 µM |
PMID: 14761193 |
|
| ZINC13559439 |
agonist |
Compound 7b |
RBA < 0.1 % |
EC50 = 0.015 µM |
PMID: 14761193 |
|
| ZINC13559440 |
agonist |
Compound 7c |
RBA < 0.1 % |
EC50 = 0.150 µM |
PMID: 14761193 |
|
| ZINC13559441 |
agonist |
Compound 9a |
RBA < 0.1 % |
EC50 = 0.780 µM |
PMID: 14761193 |
|
| ZINC13559442 |
agonist |
Compound 9b |
RBA < 0.1 % |
EC50 = 0.500 µM |
PMID: 14761193 |
|
| ZINC13560486 |
antagonist |
Compound 6 |
IC50 = 31 nM |
Inhibition = 50% |
PMID: 15006374 |
ER_beta |
| ZINC29215330 |
antagonist |
Compound 11 |
IC50 = 14 nM |
Inhibition = 46 % |
PMID: 15006374 |
ER_beta |
| ZINC00388660 |
agonist |
(S)-equol |
Ki = 200 nM |
EC50 = 85 nM |
PMID: 15018930 |
|
| CHEMBL264862 |
agonist |
Compound 4i |
IC50 = 2900 nM |
EC50 = 150 nM |
PMID: 15081034 |
ER_beta |
| CHEMBL306636 |
agonist |
Compound 4d |
IC50 = 1700 nM |
EC50 = 1700 nM |
PMID: 15081034 |
ER_beta |
| CHEMBL74757 |
agonist |
Compound 4b |
IC50 = 1700 nM |
EC50 = 64 nM |
PMID: 15081034 |
ER_beta |
| CHEMBL74758 |
agonist |
Compound 4c |
IC50 = 850 nM |
EC50 = 59 nM |
PMID: 15081034 |
ER_beta |
| CHEMBL77466 |
agonist |
Compound 4k |
IC50 = 5300 nM |
EC50 = 2000 nM |
PMID: 15081034 |
ER_beta |
| CHEMBL77930 |
agonist |
Compound 4j |
IC50 = 1200 nM |
EC50 = 170 nM |
PMID: 15081034 |
ER_beta |
| ZINC12353741 |
agonist |
Compound 4g |
IC50 = 5600 nM |
EC50 = 900 nM |
PMID: 15081034 |
ER_beta |
| ZINC12353750 |
agonist |
Compound 4f |
IC50 = 6000 nM |
EC50 = 12000 nM |
PMID: 15081034 |
ER_beta |
| ZINC26399859 |
agonist |
Compound 4e |
IC50 = 8600 nM |
EC50 = 3100 nM |
PMID: 15081034 |
ER_beta |
| ZINC34801132 |
agonist |
Compound 4h |
IC50 = 33000 nM |
EC50 = 1800 nM |
PMID: 15081034 |
ER_beta |
| ZINC53151203 |
agonist |
Compound 4a |
IC50 = 16000 nM |
EC50 = 6900 nM |
PMID: 15081034 |
ER_beta |
| CHEMBL330307 |
antagonist |
Compound 11f |
IC50 = 24.8 nM |
IC50 = 29.8 nM (%inh=66%) |
PMID: 15125923 |
ER_beta |
| CHEMBL412907 |
agonist |
Compound 6c |
IC50 = 29.8 nM |
EC50 = 11.1 nM (%act=93%) |
PMID: 15125923 |
ER_beta |
| CHEMBL89994 |
antagonist |
Compound 11c |
IC50 = 28.7 nM |
IC50 = 86.6 nM (%inh=83%) |
PMID: 15125923 |
ER_beta |
| CHEMBL93230 |
antagonist |
Compound 11i |
IC50 = 5.60 nM |
IC50 = 51.3 nM (%inh=96%) |
PMID: 15125923 |
ER_beta |
| ZINC16051648 |
agonist |
WAY-244 |
IC50 = 1152 +/- 558 nM |
|
PMID: 15341953 |
ER_beta |
| ZINC03817711 |
agonist |
Way-338 |
IC50 = 6 nM |
|
PMID: 15456246 |
ER_beta |
| ZINC13583538 |
agonist |
Compound 3 |
IC50 = 24 +/- 8 nM |
|
PMID: 15456246 |
|
| CHEMBL450940 |
agonist |
ERB-041 |
IC50 = 1048.8 nM |
|
PMID: 15548008 |
|
| ZINC03816519 |
agonist |
Way-397 |
IC50 = 161.9 nM |
|
PMID: 15548008 |
ER_beta |
| ZINC16051646 |
agonist |
Way-697 |
IC50 = 65.3 nM |
|
PMID: 15548008 |
ER_beta |
| ZINC00009252 |
agonist |
Compound 5a |
Ki = 132 +/- 2.8 nM |
|
PMID: 15634023 |
|
| ZINC13456778 |
agonist |
Compound 4a |
Ki = 261 +/- 3.2 nM |
|
PMID: 15634023 |
|
| ZINC13607302 |
agonist |
Compound 4g |
Ki = 380.8 +/- 2.2 nM |
|
PMID: 15634023 |
|
| ZINC13607316 |
agonist |
Compound 5g |
Ki = 136 +/- 1.9 nM |
|
PMID: 15634023 |
|
| ZINC01530690 |
antagonist |
tamoxifen |
|
IC50 = 622 +/- 200 nM |
PMID: 15658851 |
|
| ZINC06716968 |
antagonist |
Compound 29 |
IC50 = 63 +/- 8 nM |
IC50 = 23.2 +/- 4.6 nM |
PMID: 15658851 |
|
| ZINC13607920 |
agonist |
Compound 1a |
|
EC50 = 3.47 µM (74%) |
PMID: 15658860 |
|
| ZINC13607927 |
antagonist |
Compound 2a |
|
IC50 = 0.038 µM (66%) |
PMID: 15658860 |
|
| ZINC13607930 |
agonist |
Compound 3a |
|
EC50 = 1.50 µM (101%) |
PMID: 15658860 |
ER_beta |
| ZINC13607932 |
agonist |
Compound 3b |
|
EC50 = 1.82 µM (123%) |
PMID: 15658860 |
|
| ZINC13607934 |
agonist |
Compound 3c |
|
EC50 = 1.70 µM (85%) |
PMID: 15658860 |
ER_beta |
| ZINC13607940 |
agonist |
Compound 5a |
|
EC50 = 0.085 µM (98%) |
PMID: 15658860 |
ER_beta |
| ZINC00210379 |
agonist |
Compound 33 |
|
EC50 = 211 nM |
PMID: 15713407 |
ER_beta |
| ZINC00517292 |
agonist |
Compound 31 |
|
EC50 = 203 nM |
PMID: 15713407 |
ER_beta |
| ZINC00519098 |
agonist |
Compound 24 |
|
EC50 = 835 nM |
PMID: 15713407 |
ER_beta |
| ZINC28118725 |
agonist |
Compound 22 |
|
EC50 = 50 nM |
PMID: 15713407 |
ER_beta |
| ZINC28119115 |
agonist |
Compound 29 |
|
EC50 = 21 nM |
PMID: 15713407 |
ER_beta |
| ZINC28119716 |
agonist |
Compound 11 |
|
EC50 = 36 nM |
PMID: 15713407 |
ER_beta |
| ZINC28127517 |
agonist |
Compound 20 |
|
EC50 = 43 nM |
PMID: 15713407 |
ER_beta |
| ZINC28127985 |
agonist |
Compound 13 |
|
EC50 = 336 nM |
PMID: 15713407 |
ER_beta |
| ZINC28128206 |
agonist |
Compound 21 |
|
EC50 = 68 nM |
PMID: 15713407 |
ER_beta |
| ZINC28128467 |
agonist |
Compound 15 |
|
EC50 = 92 nM |
PMID: 15713407 |
ER_beta |
| ZINC28128474 |
agonist |
Compound 25 |
|
EC50 = 138 nM |
PMID: 15713407 |
ER_beta |
| ZINC28129302 |
agonist |
Compound 16 |
|
EC50 = 173 nM |
PMID: 15713407 |
ER_beta |
| ZINC28129315 |
agonist |
Compound 32 |
|
EC50 = 143 nM |
PMID: 15713407 |
ER_beta |
| ZINC28131038 |
agonist |
Compound 17 |
|
EC50 = 2411 nM |
PMID: 15713407 |
ER_beta |
| ZINC28132349 |
agonist |
Compound 8 |
|
EC50 = 137 nM |
PMID: 15713407 |
ER_beta |
| ZINC28135139 |
agonist |
Compound 19 |
|
EC50 = 203 nM |
PMID: 15713407 |
ER_beta |
| ZINC28136021 |
agonist |
Compound 27 |
|
EC50 = 2.6 nM |
PMID: 15713407 |
ER_beta |
| ZINC28136565 |
agonist |
Compound 18 |
|
EC50 = 1980 nM |
PMID: 15713407 |
ER_beta |
| ZINC28136625 |
agonist |
Compound 9 |
|
EC50 = 743 nM |
PMID: 15713407 |
ER_beta |
| ZINC28128148 |
antagonist |
cm4 |
IC50 = 1.5 nM |
IC50 = 1.5 nM |
PMID: 15745820 |
|
| CHEMBL189585 |
antagonist |
Compound 4b |
RBA = 53 +/- 6 % |
|
PMID: 15828819 |
|
| CHEMBL192257 |
antagonist |
Compound 4a |
RBA = 85 +/- 4 % |
|
PMID: 15828819 |
|
| CHEMBL362942 |
antagonist |
Compound 4d |
RBA = 14.5 +/- 0.3 % |
|
PMID: 15828819 |
|
| CHEMBL371370 |
antagonist |
Compound 4c |
RBA = 10.6 +/- 0.2 % |
|
PMID: 15828819 |
|
| ZINC00001219 |
agonist |
coumestrol |
IC50 = 75.7 nM |
|
PMID: 15887952 / PMID:
7556010 |
|
| CHEMBL374443 |
antagonist |
Compound 8 |
RBA = 15 +/- 3 % |
|
PMID: 15943468 |
|
| ZINC13644966 |
agonist |
Compound 10 |
RBA = 47 +/- 5 % |
|
PMID: 15943468 |
|
| ZINC13644973 |
agonist |
Compound 11 |
RBA = 9.3 +/- 0.8 % |
|
PMID: 15943468 |
|
| ZINC13644979 |
agonist |
Compound 12 |
RBA = 1.8 +/- 0.3 % |
|
PMID: 15943468 |
|
| ZINC13558846 |
agonist |
Compound 6a- (E) |
RBA = 9 % |
|
PMID: 15974584 |
|
| ZINC13558847 |
agonist |
Compound 6c-(E) |
RBA = 25% |
|
PMID: 15974584 |
|
| ZINC13558848 |
agonist |
Compound 6d-(E) |
RBA = 27% |
|
PMID: 15974584 |
|
| ZINC13558849 |
agonist |
Compound 6e-(E) |
RBA = 18% |
|
PMID: 15974584 |
|
| ZINC13558850 |
agonist |
Compound 6i-(E) |
RBA = 60% |
|
PMID: 15974584 |
|
| ZINC13558853 |
agonist |
Compound 6f-(E) |
RBA = 8% |
|
PMID: 15974584 |
|
| ZINC13558854 |
agonist |
Compound 6g-(E) |
RBA = 32% |
|
PMID: 15974584 |
|
| ZINC13558855 |
agonist |
Compound 6b-(E) |
RBA = 22 % |
|
PMID: 15974584 |
|
| ZINC36424691 |
agonist |
Compound 6b-(Z) |
RBA = 44 % |
|
PMID: 15974584 |
|
| ZINC36425059 |
agonist |
Compound 6g-(Z) |
RBA = 39% |
|
PMID: 15974584 |
|
| ZINC38331889 |
agonist |
Compound 6d-(Z) |
RBA = 12% |
|
PMID: 15974584 |
|
| ZINC40540358 |
agonist |
Compound 6a- (Z) |
RBA = 66 % |
|
PMID: 15974584 |
|
| ZINC40540421 |
agonist |
Compound 6c-(Z) |
RBA = 25% |
|
PMID: 15974584 |
|
| ZINC40743322 |
agonist |
Compound 6f-(Z) |
RBA = 9% |
|
PMID: 15974584 |
|
| ZINC40747292 |
agonist |
Compound 6h-(Z) |
RBA = 26% |
|
PMID: 15974584 |
|
| ZINC58618270 |
agonist |
Compound 6i-(Z) |
RBA = 29% |
|
PMID: 15974584 |
|
| ZINC58649039 |
agonist |
Compound 6e-(Z) |
RBA = 9% |
|
PMID: 15974584 |
|
| CHEMBL306878 |
agonist |
NC-1 |
RBA = 28 % |
EC50 = 0.059 +/- 0.012 nM (Eff=102 +/- 13%) |
PMID: 16162002 |
ER_beta |
| CHEMBL371192 |
agonist |
NC-4 |
RBA = 0.4 % |
EC50 = 152 +/- 25 nM (Eff=96 +/-9%) |
PMID: 16162002 |
ER_beta |
| CHEMBL370609 |
agonist |
NC-7 |
RBA = 12 % |
EC50 = 158 +/- 6 nM (Eff=110 +/- 12%) |
PMID: 16162002 |
ER_beta |
| ZINC12353813 |
agonist |
NC-14 |
RBA = 15 % |
EC50 = 14 +/- 3 nM (Eff=77 +/- 3%) |
PMID: 16162002 |
ER_beta |
| ZINC13555419 |
agonist |
NC-3 |
RBA = 209 % |
EC50 = 0.31 +/- 0.13 nM (Eff=69 +/- 10%) |
PMID: 16162002 |
ER_beta |
| ZINC13673467 |
agonist |
NC-8 |
RBA = 9 % |
EC50 = 4.3 +/- 1.6 nM (Eff=90 +/- 12%) |
PMID: 16162002 |
|
| ZINC13673471 |
antagonist |
NC-10 |
RBA = 10 % |
Ki = 1.7 +/- 0.5 nM |
PMID: 16162002 |
ER_beta |
| ZINC13673473 |
agonist |
NC-11 |
RBA = 20 % |
EC50 = 3.9 +/- 1.7 nM (Eff=77 +/- 4%) |
PMID: 16162002 |
|
| ZINC13673477 |
agonist |
NC-13 |
RBA = 14 % |
EC50 = 17 +/- 7 nM (Eff=73 +/-3%) |
PMID: 16162002 |
ER_beta |
| ZINC13673486 |
antagonist |
NC-19 |
RBA = 12 % |
Ki = 4.2 +/- 1.3 |
PMID: 16162002 |
ER_beta |
| ZINC13673488 |
antagonist |
NC-20 |
RBA = 1 % |
Ki = 7.3 +/- 1.7 nM |
PMID: 16162002 |
ER_beta |
| ZINC28564598 |
agonist |
Compound 14 |
IC50 = 24.0 +/- 13.9 nM |
EC50 = 38.5 nM |
PMID: 16219463 |
|
| ZINC28565011 |
agonist |
Compound 11 |
IC50 = 403 +/- 207 nM |
EC50 = 243 nM |
PMID: 16219463 |
|
| CHEMBL223065 |
antagonist |
Compound 12a |
RBA = 9.3 +/- 0.6 % |
|
PMID: 16279785 |
ER_beta |
| CHEMBL389013 |
antagonist |
Compound 12b |
RBA = 0.64 +/- 0.2 % |
|
PMID: 16279785 |
ER_beta |
| ZINC13685353 |
agonist |
Compound 1aa |
IC50 = 11097 nM |
EC50 = 2918 nM |
PMID: 16610787 |
ER_beta |
| ZINC13685362 |
agonist |
Compound 1ac |
IC50 = 4382 nM |
EC50 = 5305 nM |
PMID: 16610787 |
|
| ZINC13685365 |
agonist |
Compound 1ad |
IC50 = 55015 nM |
EC50 = 5137 nM |
PMID: 16610787 |
|
| ZINC13685368 |
agonist |
Compound 1ae |
IC50 = 44175 nM |
EC50 = 3112 nM |
PMID: 16610787 |
|
| ZINC13685377 |
agonist |
Compound 1ag |
IC50 = 7485 nM |
EC50 = 1143 nM |
PMID: 16610787 |
ER_beta |
| ZINC13685380 |
agonist |
Compound 1ah |
IC50 = 6247 nM |
EC50 = 1427 nM |
PMID: 16610787 |
|
| ZINC13685385 |
agonist |
Compound 1ai |
IC50 = 34626 nM |
EC50 = 4576 nM |
PMID: 16610787 |
|
| ZINC13685401 |
agonist |
Compound 1am |
IC50 = 40 % |
EC50 = 8317 nM |
PMID: 16610787 |
|
| ZINC13685406 |
agonist |
Compound 1ao |
IC50 = 15297 nM |
EC50 = 9344 nM |
PMID: 16610787 |
ER_beta |
| ZINC13685414 |
agonist |
Compound 1at |
IC50 = 43814 nM |
EC50 = 10082 nM |
PMID: 16610787 |
|
| ZINC13685425 |
agonist |
Compound 1aw |
IC50 = 19437 nM |
EC50 = 9317 nM |
PMID: 16610787 |
|
| ZINC13685443 |
agonist |
Compound 1aac |
IC50 = 11111 nM |
EC50 = 983 nM |
PMID: 16610787 |
ER_beta |
| ZINC13685464 |
agonist |
Compound 1aaj |
IC50 = 9635 nM |
EC50 = 2392 nM |
PMID: 16610787 |
|
| ZINC13685468 |
agonist |
Compound 1aan |
IC50 = 13240 nM |
EC50 = 4521 nM |
PMID: 16610787 |
ER_beta |
| ZINC13685471 |
agonist |
Compound 1aao |
IC50 = 38 % |
EC50 = 4624 nM |
PMID: 16610787 |
|
| ZINC13685484 |
agonist |
Compound 1aas |
IC50 = 43968 nM |
EC50 = 4261 nM |
PMID: 16610787 |
|
| ZINC13685486 |
agonist |
Compound 1ba |
IC50 = 2636 nM |
EC50 = 2793 nM |
PMID: 16610787 |
|
| ZINC13685491 |
agonist |
Compound 1bb |
IC50 = 3080 nM |
EC50 = 776 nM |
PMID: 16610787 |
|
| ZINC13685495 |
agonist |
Compound 1bc |
IC50 = 2854 nM |
EC50 = 2406 nM |
PMID: 16610787 |
|
| ZINC13685498 |
agonist |
Compound 1bd |
IC50 = 1753 nM |
EC50 = 1669 nM |
PMID: 16610787 |
ER_beta |
| ZINC13685503 |
agonist |
Compound 1be |
IC50 = 2260 nM |
EC50 = 1462 nM |
PMID: 16610787 |
|
| ZINC13685507 |
agonist |
Compound 1bf |
IC50 = 27569 nM |
EC50 = 4859 nM |
PMID: 16610787 |
ER_beta |
| ZINC03814379 |
agonist |
Nandrolone |
|
|
PMID: 16616843 |
AR |
| ZINC00155246 |
agonist |
methoxyychlor |
|
EC50 = 4 +/- 2 µM (33.4 +/- 0.2 %) |
PMID: 16626760 |
|
| ZINC00187200 |
agonist |
OBCP-1M |
Ki = 1800 nM |
EC50 = 13 nM |
PMID: 16648639 |
|
| ZINC04027098 |
agonist |
OBCP-3M |
Ki = 560 nM |
EC50 = 7 nM |
PMID: 16648639 |
|
| ZINC36773869 |
agonist |
OBCP-2M |
Ki = 570 nM |
EC50 = 9.3 nM |
PMID: 16648639 |
|
| ZINC03807917 |
agonist |
Dehydroepiandrosterone |
|
RLA = 7.5 +/- 0.5 |
PMID: 16684650 |
|
| CHEMBL213296 |
antagonist |
Compound 19e |
RBA = 0.8% |
%inhibition = 86% |
PMID: 16709454 |
|
| CHEMBL213297 |
antagonist |
Compound 19i |
RBA = 0.2% |
%inhibition = 79% |
PMID: 16709454 |
|
| CHEMBL213688 |
antagonist |
Compound 19b |
RBA = 0.6% |
%inhibition = 93% |
PMID: 16709454 |
|
| CHEMBL277278 |
antagonist |
Compound 7 |
RBA = 7 % |
%inhibition = 40 % |
PMID: 16709454 |
|
| CHEMBL377537 |
antagonist |
Compound 2 |
RBA = 96% |
%inhibition = 66 % |
PMID: 16709454 |
|
| CHEMBL379646 |
antagonist |
Compound 19a |
RBA = 0.5% |
%inhibition = 20 % |
PMID: 16709454 |
|
| CHEMBL379976 |
antagonist |
Compound 19f |
RBA = 0.3% |
%inhibition = 85% |
PMID: 16709454 |
|
| CHEMBL379977 |
antagonist |
Compound 19g |
RBA = 0.9% |
%inhibition = 81% |
PMID: 16709454 |
|
| CHEMBL379979 |
antagonist |
Compound 19h |
RBA = 0.4% |
%inhibition = 86% |
PMID: 16709454 |
|
| CHEMBL380016 |
antagonist |
Compound 19c |
RBA = 0.3% |
%inhibition = 93% |
PMID: 16709454 |
|
| CHEMBL380233 |
antagonist |
Compound 19d |
RBA = 1.3 % |
%inhibition = 87% |
PMID: 16709454 |
|
| CHEMBL384561 |
antagonist |
Compound 1 |
RBA = 200 % |
%inhibition = 51% |
PMID: 16709454 |
|
| CHEMBL439153 |
antagonist |
Compound 19j |
RBA = 0.2% |
%inhibition = 62% |
PMID: 16709454 |
|
| ZINC03982169 |
antagonist |
Compound 6 |
RBA = 0.8 % |
%inhibition = 77 % |
PMID: 16709454 |
|
| ZINC44053162 |
antagonist |
Compound 15 |
RBA = 42 % |
%inhibition = 41 % |
PMID: 16709454 |
|
| ZINC44265596 |
antagonist |
Compound 10 |
RBA = 52 % |
%inhibition = 31 % |
PMID: 16709454 |
|
| CHEMBL211870 |
agonist |
Compound 34 |
IC50 = 197 nM |
EC50 = 33.1 nM (71%) |
PMID: 16730987 |
ER_beta |
| CHEMBL211953 |
agonist |
Compound 9 |
IC50 = 223 nM |
EC50 = 59 nM (67%) |
PMID: 16730987 |
ER_beta |
| ZINC03943533 |
agonist |
Compound 5 |
IC50 = 1360 nM |
EC50 = 104 nM (78%) |
PMID: 16730987 |
ER_beta |
| ZINC34633802 |
agonist |
Compound 35 |
IC50 = 50.9 nM |
EC50 = 8.3 nM (75%) |
PMID: 16730987 |
ER_beta |
| ZINC34633808 |
agonist |
Compound 17 |
IC50 = 229 nM |
EC50 = 61 nM (70%) |
PMID: 16730987 |
ER_beta |
| ZINC34633839 |
agonist |
Compound 29 |
IC50 = 58 nM |
EC50 = 10.4 nM (90%) |
PMID: 16730987 |
ER_beta |
| CHEMBL212392 |
agonist |
Compound 26 |
IC50 = 6173 nM |
EC50 = 449 nM (84%) |
PMID: 16777408 |
ER_beta |
| CHEMBL213070 |
agonist |
Compound 37 |
IC50 = 3301 nM |
EC50 = 561 nM (93%) |
PMID: 16777408 |
ER_beta |
| CHEMBL213529 |
agonist |
Compound 27 |
IC50 = 612 nM |
EC50 = 120 nM (74%) |
PMID: 16777408 |
ER_beta |
| CHEMBL214693 |
agonist |
Compound 1 |
IC50 = 141 nM |
EC50 = 94 nM (68%) |
PMID: 16777408 |
ER_beta |
| CHEMBL215802 |
agonist |
Compound 38 |
IC50 = 1906 nM |
EC50 = 519 nM (80%) |
PMID: 16777408 |
ER_beta |
| CHEMBL378883 |
agonist |
Compound 41 |
IC50 = 352 nM |
EC50 = 794 nM (76%) |
PMID: 16777408 |
ER_beta |
| CHEMBL379314 |
agonist |
Compound 24 |
IC50 = 1900 nM |
EC50 = 671 nM (62%) |
PMID: 16777408 |
ER_beta |
| CHEMBL384709 |
agonist |
Compound 40 |
IC50 = 896 nM |
EC50 = 169 nM (81%) |
PMID: 16777408 |
ER_beta |
| CHEMBL385028 |
agonist |
Compound 36 |
IC50 = 5170 nM |
EC50 = 1267 nM (61%) |
PMID: 16777408 |
ER_beta |
| ZINC34003569 |
agonist |
Compound 25 S |
IC50 = 647 nM |
EC50 = 140 nM (85%) |
PMID: 16777408 |
ER_beta |
| ZINC34052305 |
agonist |
Compound 29 S |
IC50 = 220 nM |
EC50 = 30 nM (78%) |
PMID: 16777408 |
ER_beta |
| ZINC34633837 |
agonist |
Compound 39 S |
IC50 = 1678 nM |
EC50 = 241 nM (78%) |
PMID: 16777408 |
ER_beta |
| CHEMBL1627806 |
antagonist |
Compound 10f |
RBA = 0.7 % |
% inhibition = 27 +/- 9 % |
PMID: 16806917 |
|
| CHEMBL1627808 |
antagonist |
Compound 10e |
RBA = 0.7 % |
% inhibition = 27 +/- 6 % |
PMID: 16806917 |
|
| CHEMBL1627809 |
antagonist |
Compound 10c |
RBA = 0.6 % |
% inhibition = 55 +/- 9 % |
PMID: 16806917 |
|
| CHEMBL1627810 |
antagonist |
Compound 10d |
RBA = 1.4 % |
% inhibition = 22 +/- 5 % |
PMID: 16806917 |
|
| CHEMBL1628015 |
antagonist |
Compound 10a |
RBA = 0.8 % |
% inhibition = 37 +/- 5 % |
PMID: 16806917 |
|
| ZINC49592770 |
antagonist |
Compound 12b |
RBA = 1.0 % |
% inhibition = 54 +/- 6 % |
PMID: 16806917 |
|
| ZINC49865005 |
antagonist |
Compound 11a |
RBA = 1.0 % |
% inhibition = 58 +/- 2 % |
PMID: 16806917 |
|
| ZINC49942259 |
antagonist |
Compound 11b |
RBA = 1.1 % |
% inhibition = 59 +/- 6 % |
PMID: 16806917 |
|
| ZINC12353762 |
agonist |
SERBA-1 |
Ki = 2.68 +/- 0.21 nM |
EC50 = 19.4 +/- 1.13 nM (94 +/- 1.7%) |
PMID: 17034120 |
ER_beta |
| ZINC14972389 |
agonist |
SERBA-2 |
Ki = 14.5 +/- 6.4 nM |
EC50 = 32.5 +/- 18.2 nM(84 +/- 14%) |
PMID: 17034120 |
ER_beta |
| ZINC18847036 |
agonist |
formononetin |
|
|
PMID: 17135037 |
|
| ZINC14814929 |
agonist |
Compound 8a |
IC50 = 5245 +/- 611 nM |
|
PMID: 17149865 |
ER_beta |
| ZINC14970962 |
agonist |
Compound 8b |
IC50 = 155 +/- 36 nM |
|
PMID: 17149865 |
ER_beta |
| ZINC14970969 |
agonist |
Compound 8c |
IC50 = 383 +/- 123 nM |
|
PMID: 17149865 |
|
| ZINC14971002 |
agonist |
Compound 8g |
IC50 = 140 +/- 31 nM |
|
PMID: 17149865 |
|
| ZINC14971010 |
agonist |
Compound 8h |
IC50 = 80 +/- 10 nM |
|
PMID: 17149865 |
ER_beta |
| ZINC14971018 |
agonist |
Compound 8i |
IC50 = 216 +/- 44 nM |
|
PMID: 17149865 |
|
| ZINC14971026 |
agonist |
Compound 8j |
IC50 = 503 +/- 103 nM |
|
PMID: 17149865 |
ER_beta |
| ZINC13584998 |
antagonist |
Compound 3 |
Ki = 26 nM |
IC50 = 6 µM |
PMID: 17228884 |
ER_beta |
| ZINC14970946 |
antagonist |
Compound 12a |
Ki = 7 nM |
IC50 = 90 nM |
PMID: 17228884 |
ER_beta |
| ZINC14970950 |
antagonist |
Compound 12b |
Ki = 47 nM |
IC50 = 1 µM |
PMID: 17228884 |
ER_beta |
| ZINC34569930 |
agonist |
Compound 4c |
RBA = 75 % |
|
PMID: 17266199 |
|
| ZINC35242324 |
agonist |
Compound 3a |
RBA = 15 % |
|
PMID: 17266199 |
|
| ZINC35242326 |
agonist |
Compound 3c |
RBA = 65 % |
|
PMID: 17266199 |
|
| ZINC35242328 |
agonist |
Compound 3b |
RBA = 212 % |
|
PMID: 17266199 |
|
| ZINC35242329 |
agonist |
Compound 3d |
RBA = 5 % |
|
PMID: 17266199 |
|
| ZINC13980197 |
antagonist |
Compound 1f |
RBA = 5.0 % |
|
PMID: 17337183 |
|
| ZINC13980198 |
antagonist |
Compound 1b |
RBA = 0.287 % |
|
PMID: 17337183 |
|
| ZINC14209386 |
antagonist |
Compound 1d |
RBA = 0.192 % |
|
PMID: 17337183 |
|
| ZINC28568460 |
agonist |
Compound 1 |
IC50 = 2240 nM |
EC50 = 980 nM |
PMID: 17448656 |
ER_beta |
| ZINC28569925 |
agonist |
Compound 3 |
IC50 = 1956 nM |
EC50 = 344 nM |
PMID: 17448656 |
ER_beta |
| ZINC28896662 |
agonist |
Compound 7 |
IC50 = 4990 nM |
EC50 = 1300 nM |
PMID: 17448656 |
|
| ZINC28896668 |
agonist |
Compound 8 |
IC50 = 317 nM |
EC50 = 44 nM |
PMID: 17448656 |
ER_beta |
| ZINC28896673 |
agonist |
Compound 9 |
IC50 = 8135 nM |
EC50 = 435 nM |
PMID: 17448656 |
ER_beta |
| ZINC34047731 |
agonist |
TFMPV-E2 |
Kd = 50 pM |
|
PMID: 17468738 |
|
| ZINC28821981 |
agonist |
Compound 4c |
Ki = 0.35 +/- 0.04 nM |
|
PMID: 17485205 |
|
| CHEMBL239723 |
agonist |
Compound 8a |
IC50 = 2.95 µM |
EC50 = 15.2 +/- 2.02 µM |
PMID: 17574424 |
ER_beta |
| CHEMBL239938 |
agonist |
Compound 8b |
IC50 = 1.41 µM |
EC50 = 24.33 +/- 3.9 µM |
PMID: 17574424 |
ER_beta |
| CHEMBL391619 |
antagonist |
Compound 8c |
IC50 = 2.47 µM |
IC50 = 2.65 +/- 0.49 µM |
PMID: 17574424 |
ER_beta |
| CHEMBL392029 |
antagonist |
Compound 8d |
IC50 = 1.63 µM |
IC50 = 5.57 +/- 0.30 µM |
PMID: 17574424 |
|
| ZINC14972438 |
agonist |
Compound 2b |
Ki = 8.3 +/- 2.7 nM |
|
PMID: 17614275 |
ER_beta |
| CHEMBL1628029 |
agonist |
Compound 2 |
IC50 = 193 nM |
|
PMID: 17696335 |
ER_beta |
| CHEMBL440283 |
agonist |
androstenediol |
IC50 = 180 nM |
EC50 = 26 nM (91%) |
PMID: 17890084 |
ER_beta |
| ZINC28569835 |
agonist |
Compound 11 |
IC50 =150 nM |
EC50 = 130 nM (82%) |
PMID: 17890084 |
ER_beta |
| CHEMBL485889 |
agonist |
Compound 19 |
|
Receptor
activation = 67.6 % |
PMID: 18517258 |
|
| ZINC40424177 |
agonist |
Compound 4f |
RBA = 0.153 % |
EC50 = 11 nM (130%) |
PMID: 18760603 |
ER_beta |
| ZINC40424544 |
agonist |
Compound 11b |
RBA = 0.193 % |
EC50 = 14 nM (114%) |
PMID: 18760603 |
ER_beta |
| ZINC40428697 |
agonist |
Compound 8 |
RBA = 0.336 % |
EC50 = 5.2 nM (240%) |
PMID: 18760603 |
ER_beta |
| ZINC40952765 |
agonist |
Compound 4l |
RBA = 1.130 % |
EC50 = 0.59 µM (64%) |
PMID: 18760603 |
ER_beta |
| ZINC40952767 |
agonist |
Compound 4m |
RBA = 1.295 % |
EC50 = 0.12 µM (87%) |
PMID: 18760603 |
ER_beta |
| ZINC40974788 |
agonist |
Compound 4i |
RBA = 0.551 % |
EC50 = 11 µM (77%) |
PMID: 18760603 |
ER_beta |
| ZINC40975017 |
agonist |
Compound 4j |
RBA = 0.655 % |
EC50 = 67 nM (85%) |
PMID: 18760603 |
ER_beta |
| ZINC40975931 |
agonist |
Compound 4h |
RBA = 3.643 % |
EC50 = 0.5 µM (71%) |
PMID: 18760603 |
ER_beta |
| ZINC40976494 |
agonist |
Compound 12b |
RBA = 0.040 % |
EC50 = 63 nM (98%) |
PMID: 18760603 |
|
| ZINC40976496 |
agonist |
Compound 12c |
RBA = 0.352 % |
EC50 = 12 nM (99%) |
PMID: 18760603 |
ER_beta |
| ZINC40977295 |
agonist |
Compound 4g |
RBA = 0.890 % |
EC50 = 0.21 µM (109%) |
PMID: 18760603 |
ER_beta |
| ZINC12404516 |
antagonist |
toremifen |
|
|
PMID: 18820866 |
|
| ZINC40420820 |
agonist |
Compound 2 |
EC50 = 0.010 µM |
relative transcription = 0.8 % |
PMID: 18942824 |
|
| ZINC03996033 |
antagonist |
MPP |
RBA = 12 +/- 2 % |
|
PMID: 19014882 |
|
| ZINC40919073 |
antagonist |
Compound 2 |
RBA=1.6 +/- 0.5 % |
|
PMID: 19014882 |
|
| ZINC40934007 |
antagonist |
MPrP |
RBA = 5.1 +/- 1.7 % |
|
PMID: 19014882 |
|
| CHEMBL504563 |
antagonist |
Compound 4 |
|
|
PMID: 19133777 |
|
| ZINC40861576 |
agonist |
Compound 9e |
RBA = 27 % |
RTA = 44 % |
PMID: 19167882 |
ER_beta |
| CHEMBL554507 |
agonist |
Compound 21 |
RBA = 0.71 +/- 0.08 % |
EC50 = 6.5 nM |
PMID: 19286283 |
|
| CHEMBL562860 |
agonist |
Compound 37b |
RBA = 0.32 +/- 0.04 % |
EC50 = 10.7 n M |
PMID: 19286283 |
|
| CHEMBL572894 |
agonist |
Compound 38b |
RBA = 0.77 +/- 0.06 % |
EC50 = 20.2 nM |
PMID: 19286283 |
|
| CHEMBL574524 |
agonist |
Compound 22 |
RBA = 3.2 +/- 1.0 % |
EC50 = 2.0 nM |
PMID: 19286283 |
|
| ZINC01562031 |
agonist |
Compound 25 |
RBA = 0.057 +/- 0.017 % |
EC50 = 75.1 nM |
PMID: 19286283 |
|
| ZINC04654868 |
agonist |
Compound 26 |
RBA = 0.218 +/- 0.025 % |
EC50 = 11.2 nM |
PMID: 19286283 |
|
| ZINC33956243 |
agonist |
Compound 27 |
RBA = 4.09 +/- 0.81 % |
EC50 = 0.52 nM |
PMID: 19286283 |
|
| ZINC45291327 |
agonist |
Compound 36b |
RBA = 0.132 +/- 0.002 % |
EC50 = 16.2 nM |
PMID: 19286283 |
|
| CHEMBL539462 |
agonist |
Compound 19 |
RBA = 0.009 +/- 0.003 % |
EC50 = 65 nM |
PMID: 19394116 |
|
| ZINC42921601 |
agonist |
Compound 31b |
RBA = 0.7 +/- 0.2 % |
EC50 = 0.11 nM |
PMID: 19394116 |
|
| ZINC42922029 |
agonist |
Compound 32b |
RBA = 3.3 +/- 0.7 % |
EC50 = 0.11 nM |
PMID: 19394116 |
ER_beta |
| ZINC42922033 |
agonist |
Compound 32a |
RBA = 0.035 +/- 0.006 % |
EC50 = 16 nM |
PMID: 19394116 |
|
| ZINC00985403 |
agonist |
liquiritigenin |
|
EqE10 = 0.01 µM |
PMID: 19928832 |
|
| ZINC01849484 |
agonist |
Compound 15 |
|
EC50 = 0.05 nM |
PMID: 20334368 |
|
| ZINC13494223 |
agonist |
Compound 3 |
|
EC50 = 0.15 nM |
PMID: 20334368 |
|
| ZINC49072677 |
agonist |
Compound 6 |
|
EC50 = 0.1 nM |
PMID: 20334368 |
|
| ZINC49109511 |
agonist |
Compound 12 |
|
EC50 = 4 nM |
PMID: 20334368 |
|
| ZINC49112048 |
agonist |
Compound 7 |
|
EC50 = 0.1 nM |
PMID: 20334368 |
|
| ZINC49112817 |
agonist |
Compound 3f |
logIC50 = - 7.129+/-0.227 |
logEC50 = -7.444 +/- 0.076 M |
PMID: 20408532 |
ER_beta |
| ZINC49115140 |
agonist |
Compound 3b |
logIC50 = - 6.614+/-0.094 |
logEC50 = -6.474 +/- 0.051 M |
PMID: 20408532 |
|
| ZINC49781421 |
agonist |
Compound 3e |
logIC50 = - 6.467+/-0.131 |
logEC50 = -7.036 +/- 0.041 M |
PMID: 20408532 |
ER_beta |
| CHEMBL1094216 |
agonist |
Compound 44ab |
RBA = 0.03 % |
Recept. activation = 69.5 % |
PMID: 20430632 |
|
| CHEMBL1095869 |
agonist |
Compound 49ab |
RBA = 0.24 % |
Recept. activation = 83.3 % |
PMID: 20430632 |
|
| CHEMBL1097449 |
agonist |
Compound 10ab |
RBA = 0.03 % |
Recept. activation = 55.0 % |
PMID: 20430632 |
ER_beta |
| CHEMBL1097457 |
agonist |
Compound 30ab |
RBA = 1.90 % |
Recept. activation = 105.2 % |
PMID: 20430632 |
ER_beta |
| CHEMBL1097837 |
agonist |
Compound 21ab |
RBA = 10.60 % |
Recept. activation = 87.3 % |
PMID: 20430632 |
|
| CHEMBL1097838 |
agonist |
Compound 22ab |
RBA = 0.05 % |
Recept. activation = 46.8 % |
PMID: 20430632 |
|
| CHEMBL1099199 |
agonist |
Compound 51ab |
RBA = 0.32 % |
Recept. activation = 90.9 % |
PMID: 20430632 |
ER_beta |
| ZINC13341109 |
agonist |
Compound 1 |
IC50 = 8.1 +/- 0.8 µM |
EC50 = 1.59 µM |
PMID: 20493686 |
ER_beta |
| CHEMBL1082422 |
agonist |
Compound 2g |
|
EC50 = 27.2 +/- 7.4 µM |
PMID: 20553023 |
ER_beta |
| CHEMBL1082742 |
antagonist |
Compound 3c |
|
IC50 = 6.13 +/- 0.60 µM |
PMID: 20553023 |
ER_beta |
| CHEMBL1083881 |
antagonist |
Compound 1b |
|
IC50 = 7.98 +/- 1.07 µM |
PMID: 20553023 |
ER_beta |
| CHEMBL1083981 |
antagonist |
Compound 3a |
|
IC50 = 2.32 +/- 0.20 µM |
PMID: 20553023 |
ER_beta |
| ZINC00359736 |
agonist |
Compound 2k |
|
EC50 = 12.8 +/- 0.77 µM |
PMID: 20553023 |
ER_beta |
| ZINC00383740 |
antagonist |
Compound 3b |
|
IC50 = 1.20 +/- 0.12 µM |
PMID: 20553023 |
ER_beta |
| ZINC00383800 |
antagonist |
Compound 3e |
|
IC50 = 31.6 +/- 3.1 µM |
PMID: 20553023 |
ER_beta |
| ZINC00385937 |
agonist |
Compound 2j |
|
EC50 = 3.08 +/- 0.28 µM |
PMID: 20553023 |
ER_beta |
| ZINC04167143 |
agonist |
Compound 2c |
|
EC50 = 0.415 +/- 0.024 µM |
PMID: 20553023 |
ER_beta |
| ZINC04183878 |
antagonist |
Compound 1a |
|
IC50 = 4.66 +/- 1.29 µM |
PMID: 20553023 |
ER_beta |
| ZINC04473320 |
agonist |
Compound 2i |
|
EC50 = 18.7 +/- 3.2 µM |
PMID: 20553023 |
ER_beta |
| ZINC04656499 |
agonist |
Compound 2f |
|
EC50 = 4.13 +/- 0.39 µM |
PMID: 20553023 |
ER_beta |
| ZINC04666452 |
antagonist |
Compound 3d |
|
IC50 = 0.795 +/- 0.14 µM |
PMID: 20553023 |
ER_beta |
| ZINC05634978 |
agonist |
Compound 2h |
|
EC50 = 35.8 +/- 8.7 µM |
PMID: 20553023 |
ER_beta |
| ZINC05730717 |
agonist |
Compound 2e |
|
EC50 = 0.231 +/- 0.01 µM |
PMID: 20553023 |
ER_beta |
| ZINC05731164 |
agonist |
Compound 2d |
|
EC50 = 0.331 +/- 0.01 µM |
PMID: 20553023 |
ER_beta |
| ZINC05731330 |
agonist |
Compound 2a |
|
EC50 = 59.1 +/- 0.54 nM |
PMID: 20553023 |
ER_beta |
| ZINC06557091 |
agonist |
Compound 2b |
|
EC50 = 43.8 +/- 2.85 nM |
PMID: 20553023 |
ER_beta |
| ZINC64245782 |
antagonist |
Compound 7e |
RBA = 0.34 % |
IC50 = 1.13 µM |
PMID: 20598555 |
|
| ZINC64245801 |
antagonist |
Compound 7d |
RBA = 0.48 % |
IC50 = 1.30 µM |
PMID: 20598555 |
|
| ZINC64251813 |
antagonist |
Compound 7b |
RBA = 0.43 % |
IC50 = 1.31 µM |
PMID: 20598555 |
|
| ZINC64264576 |
antagonist |
Compound 7a |
RBA = 0.54 % |
IC50 = 5.1 µM |
PMID: 20598555 |
|
| ZINC64428959 |
antagonist |
Compound 7c |
RBA = 0.92 % |
IC50 = 0.31 µM |
PMID: 20598555 |
|
| ZINC00968077 |
agonist |
Compound 3a |
binding max = 82.7% |
max agonist = 68.5 % |
PMID: 20669983 |
|
| ZINC02576403 |
agonist |
Compound 3b |
binding max = 66.6% |
max agonist = 79 % |
PMID: 20669983 |
|
| ZINC13376926 |
antagonist |
Compound 2 |
binding max = 44 % |
max inhibition = 100 % |
PMID: 20669983 |
|
| ZINC18847034 |
agonist |
daidzein |
binding max = 112 % |
max agonist = 108.5 % |
PMID: 20669983 |
ERR_alpha |
| ZINC58581031 |
antagonist |
Compound 3g |
binding max = 19.2% |
max inhibition = 89.8% |
PMID: 20669983 |
|
| ZINC58582484 |
antagonist |
Compound 3f |
binding max = 38.3% |
max inhibition = 91.3% |
PMID: 20669983 |
|
| ZINC64538996 |
agonist |
Compound 12b |
|
logEC50 = -7.450 +/- 0.080 |
PMID: 20812681 |
|
| ZINC64538997 |
agonist |
Compound 11b |
|
logEC50 = -6.314 +/- 0.069 |
PMID: 20812681 |
|
| ZINC64539908 |
agonist |
Compound 11c |
|
logEC50 = -6.395 +/- 0.069 |
PMID: 20812681 |
|
| ZINC64540054 |
agonist |
Compound 9b |
|
logEC50 = - 5.781 +/- 0.045 |
PMID: 20812681 |
|
| ZINC72147823 |
agonist |
Compound 11a |
|
logEC50 = -5.988 +/- 0.050 |
PMID: 20812681 |
|
| ZINC66103296 |
agonist |
Compound 1d |
RBA = 52.3 +/- 12 % |
RTA = 90 +/- 13 % |
PMID: 21190382 |
ER_beta |
| ZINC66103840 |
agonist |
Compound 5 |
RBA = 51.9 +/- 7.9 % |
RTA = 114.6 +/- 2.9 % |
PMID: 21190382 |
ER_beta |
| ZINC66111808 |
agonist |
Compound 4 |
RBA = 195 +/- 35 % |
RTA = 98.6 +/- 5.5 % |
PMID: 21190382 |
ER_beta |
| ZINC58651027 |
agonist |
Compound 8 |
|
EC50 = 5.2 +/- 0.5 µM |
PMID: 21381753 |
ER_beta |
| ZINC64754982 |
agonist |
Compound 10 |
|
EC50 = 20 +/- 5 µM |
PMID: 21381753 |
ER_beta |
| ZINC64754986 |
agonist |
Compound 19 |
|
EC50 = 3.0 +/- 0.3 µM |
PMID: 21381753 |
ER_beta |
| ZINC71315822 |
agonist |
Compound 11 |
|
EC50 = 2.3 +/- 0.3 µM |
PMID: 21381753 |
ER_beta |
| ZINC71316870 |
agonist |
Compound 14 |
|
EC50 = 170 +/- 30 µM |
PMID: 21381753 |
ER_beta |
| ZINC71316889 |
agonist |
Compound 16 |
|
EC50 = 600 +/- 173 µM |
PMID: 21381753 |
ER_beta |
| ZINC71318409 |
agonist |
Compound 9 |
|
EC50 = 340 +/- 29 µM |
PMID: 21381753 |
ER_beta |
| ZINC71329506 |
agonist |
Compound 12 |
|
EC50 = 6.2 +/- 0.3 µM |
PMID: 21381753 |
ER_beta |
| ZINC71329876 |
agonist |
Compound 15 |
|
EC50 = 700 +/- 85 µM |
PMID: 21381753 |
ER_beta |
| ZINC29136161 |
agonist |
Compound 1c |
RBA = 0.065 +/- 0.016 % |
EC50 = 26 nM (80%) |
PMID: 21481497 |
ER_beta |
| ZINC40845165 |
agonist |
Compound 1d |
RBA = 0.11 +/- 0.03 % |
EC50 = 19 nM (95%) |
PMID: 21481497 |
ER_beta |
| ZINC40933971 |
agonist |
Compound 2a |
RBA = 0.064 +/- 0.016 % |
EC50 = 17 nM (100%) |
PMID: 21481497 |
ER_beta |
| ZINC71282407 |
agonist |
Compound 2b |
RBA = 88.4 +/- 18.1 % |
EC50 = 0.30 nM (90%) |
PMID: 21481497 |
ER_beta |
| ZINC71294241 |
agonist |
Compound 2c |
RBA = 4.46 +/- 0.60 % |
EC50 = 0.58 nM (100%) |
PMID: 21481497 |
ER_beta |
| ZINC71294751 |
agonist |
Compound 2d |
RBA = 1.88 +/- 0.30 % |
EC50 = 8.4 nM (100%) |
PMID: 21481497 |
ER_beta |
| CHEMBL1836906 |
agonist |
Compound 10 |
|
EC50 = 2310 nM (79%) |
PMID: 21885279 |
|
| CHEMBL1836912 |
agonist |
Compound 16 |
|
EC50 = 3800 nM (75%) |
PMID: 21885279 |
ER_beta |
| ZINC72124547 |
agonist |
Compound 4 |
|
EC50 = 357 nM (87%) |
PMID: 21885279 |
ER_beta |
| ZINC72124974 |
agonist |
Compound 5 |
|
EC50 = 3500 nM (94%) |
PMID: 21885279 |
|
| ZINC12501375 |
antagonist |
Compound 15 |
IC50 = 0.5 nM |
%Antago = 103 % |
PMID: 22061644 |
|
| ZINC12502349 |
antagonist |
Compound 18 |
IC50 = 1.3 nM |
%Antago = 101 % |
PMID: 22061644 |
|
| ZINC28336697 |
agonist |
Compound 21 |
IC50 = 0.7 nM |
% Ago = 78 % |
PMID: 22061644 |
|
| ZINC28350246 |
antagonist |
Compound 4 |
IC50 = 3.0 nM |
%Antago = 106 % |
PMID: 22061644 |
|
| CHEMBL2031314 |
agonist |
Compound 10a |
RBA = 0.956 +/- 0.16 % |
EC50 = 670 nM (85 +/- 20%) |
PMID: 22283328 |
|
| CHEMBL2031518 |
agonist |
Compound 11a |
RBA = 8.11 +/- 1.8 % |
EC50 = 0.14 nM (62 +/- 7%) |
PMID: 22283328 |
|
| CHEMBL2031519 |
agonist |
Compound 11b |
RBA = 0.741 +/- 0.18 % |
EC50 = 210 nM (76 +/- 7%) |
PMID: 22283328 |
|
| CHEMBL2031520 |
agonist |
Compound 11c |
RBA = 3.53 +/- 0.45 % |
EC50 = 2.2 nM (56 +/- 4%) |
PMID: 22283328 |
|
| CHEMBL2031521 |
agonist |
Compound 11d |
RBA = 2.49 +/- 0.31 % |
EC50 = 2.8 nM (73 +/- 5%) |
PMID: 22283328 |
|
| CHEMBL2031522 |
agonist |
Compound 11e |
RBA = 2.21 +/- 0.60 % |
EC50 = 14 nM (67 +/- 7%) |
PMID: 22283328 |
|
| CHEMBL2031523 |
agonist |
Compound 11f |
RBA = 2.18 +/- 0.65 % |
EC50 = 200 nM (74 +/- 10%) |
PMID: 22283328 |
|
| CHEMBL2031524 |
agonist |
Compound 11g |
RBA = 2.13 +/- 0.36 % |
EC50 = 110 nM (67 +/- 5%) |
PMID: 22283328 |
|
| CHEMBL2031525 |
agonist |
Compound 11h |
RBA = 3.37 +/- 0.22 % |
EC50 = 110 nM (71 +/- 9%) |
PMID: 22283328 |
|
| CHEMBL2031527 |
agonist |
Compound 11j |
RBA = 0.998 +/- 0.22 % |
EC50 = 27 nM (59 +/- 7%) |
PMID: 22283328 |
|
| CHEMBL2031528 |
agonist |
Compound 11k |
RBA = 2.21 +/- 0.48 % |
EC50 = 9.2 nM (58 +/- 6%) |
PMID: 22283328 |
ER_beta |
| CHEMBL2031529 |
agonist |
Compound 11l |
RBA = 0.016 +/- 0.002 % |
EC50 = 150 nM (65 +/- 5%) |
PMID: 22283328 |
ER_beta |
| CHEMBL2031530 |
agonist |
Compound 12a |
RBA = 3.49 +/- 0.47 % |
EC50 = 12 nM (65 +/- 6%) |
PMID: 22283328 |
|
| CHEMBL2031531 |
agonist |
Compound 12b |
RBA = 0.310 +/- 0.05 % |
EC50 = 11000 nM (57 +/- 4%) |
PMID: 22283328 |
|
| CHEMBL2031532 |
agonist |
Compound 12c |
RBA = 2.48 +/- 0.13 % |
EC50 = 1300 nM (55 +/- 3%) |
PMID: 22283328 |
|
| CHEMBL2031533 |
agonist |
Compound 12d |
RBA = 1.18 +/- 0.18 % |
EC50 = 2000 nM (72 +/- 7%) |
PMID: 22283328 |
|
| CHEMBL2031534 |
agonist |
Compound 12e |
RBA = 0.516 +/- 0.14 % |
EC50 = 1200 nM (51 +/- 6%) |
PMID: 22283328 |
|
| CHEMBL2022003 |
agonist |
Compound 1 |
RBA = 0.03 +/- 0.01 % |
EC50 = 0.14 +/- 0.04 µM |
PMID:
22464681 |
ER_beta |
| CHEMBL2022004 |
agonist |
Compound 2 |
RBA = 0.05 +/- 0.01 % |
EC50 = 0.14 +/- 0.03 µM |
PMID:
22464681 |
ER_beta |
| CHEMBL2022005 |
agonist |
Compound 3 |
RBA = 0.03 +/- 0.01 % |
EC50 = 0.18 +/- 0.04 µM |
PMID:
22464681 |
|
| CHEMBL2022006 |
agonist |
Compound 4 |
RBA = 0.05 +/- 0.02 % |
EC50 = 0.22 +/- 0.08 µM |
PMID:
22464681 |
|
| CHEMBL2022007 |
agonist |
Compound 5 |
RBA = 0.06 +/- 0.01 % |
EC50 = 0.32 +/- 0.04 µM |
PMID:
22464681 |
ER_beta |
| CHEMBL2036418 |
antagonist |
Compound 12 |
RBA = 26 +/- 9 % |
Ki = 2.4 +/- 0.6 nM |
PMID: 22608920 |
|
| CHEMBL2036560 |
antagonist |
Compound 14 |
RBA = 51 +/- 13 % |
Ki= 1.1 +/- 0.1 nM |
PMID: 22608920 |
|
| CHEMBL2036561 |
antagonist |
RU 58668 |
RBA = 83 +/- 13 % |
Ki = 5.3 +/- 9.2 nM |
PMID: 22608920 |
|
| ZINC05764576 |
agonist |
Compound 15 |
RBA = 19.0 +/- 4.6 % |
RSA = 76 +/- 15% |
PMID: 22608920 |
|
| ZINC13555406 |
agonist |
Compound 6 |
RBA = 67 +/- 8 % |
RSA = 17 +/- 8.5 % |
PMID: 22608920 |
|
| ZINC13651931 |
agonist |
Compound 16 |
RBA = 22.5 +/- 0.7 % |
RSA = 70 +/- 5% |
PMID: 22608920 |
|
| ZINC31391321 |
antagonist |
RU39411 |
RBA = 38 +/- 9 % |
Ki = 41.5 +/- 9.2 nM |
PMID: 22608920 |
|
| ZINC73200524 |
antagonist |
Compound 11 |
RBA = 39 +/- 9 % |
|
PMID: 22608920 |
|
| CHEMBL2071176 |
agonist |
Compound 2b |
|
EC50 = 5.95 +/- 0.14 µM |
PMID: 22647217 |
ER_beta |
| ZINC00271727 |
antagonist |
Compound 1h |
|
IC50 = 2.23 +/- 0.080 µM |
PMID: 22647217 |
ER_beta |
| ZINC00365042 |
antagonist |
Compound 1k |
|
IC50 = 28.2 +/- 2.4 µM |
PMID: 22647217 |
ER_beta |
| ZINC00365043 |
agonist |
Compound 2c |
|
EC50 = 31.1 +/- 1.7 µM |
PMID: 22647217 |
ER_beta |
| ZINC00365151 |
antagonist |
Compound 3f |
|
IC50 = 4.32 +/- 0.19 µM |
PMID: 22647217 |
|
| ZINC00365167 |
antagonist |
Compound 3g |
|
IC50 = 28.1 +/- 1.6 µM |
PMID: 22647217 |
|
| ZINC00365190 |
antagonist |
Compound 1j |
|
IC50 = 3.06 +/- 0.18 µM |
PMID: 22647217 |
ER_beta |
| ZINC00365207 |
antagonist |
Compound 1e |
|
IC50 = 1.00 +/- 0.020 µM |
PMID: 22647217 |
ER_beta |
| ZINC00378186 |
antagonist |
Compound 3a |
|
IC50 = 0.29 +/- 0.020 µM |
PMID: 22647217 |
ER_beta |
| ZINC00383745 |
antagonist |
Compound 3c |
|
IC50 = 2.29 +/- 0.17 µM |
PMID: 22647217 |
ER_beta |
| ZINC00383772 |
antagonist |
Compound 1a |
|
IC50 = 0.430 +/- 0.045 µM |
PMID: 22647217 |
ER_beta |
| ZINC00383781 |
antagonist |
Compound 1c |
|
IC50 = 0.629 +/- 0.030 µM |
PMID: 22647217 |
ER_beta |
| ZINC00383788 |
antagonist |
Compound 1f |
|
IC50 = 1.98 +/- 0.17 µM |
PMID: 22647217 |
ER_beta |
| ZINC01017110 |
antagonist |
Compound 3e |
|
IC50 = 3.15 +/- 0.60 µM |
PMID: 22647217 |
ER_beta |
| ZINC01017164 |
antagonist |
Compound 3d |
|
IC50 = 1.89 +/- 0.089 µM |
PMID: 22647217 |
ER_beta |
| ZINC01017209 |
antagonist |
Compound 3b |
|
IC50 = 3.29 +/- 0.14 µM |
PMID: 22647217 |
ER_beta |
| ZINC02069659 |
antagonist |
Compound 1b |
|
IC50 = 8.77 +/- 0.58 µM |
PMID: 22647217 |
ER_beta |
| ZINC04666449 |
antagonist |
Compound 1d |
|
IC50 = 0.255 +/- 0.020 µM |
PMID: 22647217 |
ER_beta |
| ZINC04666501 |
antagonist |
Compound 1i |
|
IC50 = 10.8 +/- 1.7 µM |
PMID: 22647217 |
ER_beta |
| ZINC04666668 |
antagonist |
Compound 1g |
|
IC50 = 2.87 +/- 0.11 µM |
PMID: 22647217 |
ER_beta |
| ZINC08722915 |
agonist |
Compound 2a |
|
EC50 = 0.870 +/- 014 µM |
PMID: 22647217 |
ER_beta |
| ZINC13481431 |
agonist |
Compound 2d |
|
EC50 = 71.2 +/- 5.0 µM |
PMID: 22647217 |
ER_beta |
| CHEMBL2178792 |
agonist |
Compound 8l |
RBA = 23.3 % |
EC50 = 30 nM (88 +/-14%) |
PMID: 23043242 |
ER_beta |
| CHEMBL2178793 |
agonist |
Compound 8m |
RBA = 37.0 % |
EC50 = 23 nM (94 +/- 2%) |
PMID: 23043242 |
ER_beta |
| CHEMBL2178797 |
agonist |
Compound 8b |
RBA = 22.6 % |
EC50 = 70 nM (101 +/- 1%) |
PMID: 23043242 |
ER_beta |
| CHEMBL2179253 |
agonist |
Compound 8f |
RBA = 11.5 % |
EC50 = 63 nM (92 +/- 10%) |
PMID: 23043242 |
ER_beta |
| ZINC03815419 |
agonist |
2-hydroxy-estradiol |
Ki = 0.94 nM |
|
PMID: 2542691 |
|
| ZINC03815445 |
agonist |
Compound 33 |
RBA = 7.8 % |
Estrogenic effect = 22 % |
PMID: 2754694 |
|
| ZINC03815444 |
agonist |
Compound 20b |
RBA = 33 % |
|
PMID: 6492074 |
|
| ZINC01585847 |
antagonist |
droloxifene |
|
% Inhibition = 28.5 % |
PMID: 7131484 |
|
| ZINC01545572 |
antagonist |
Compound 13b |
RBA = 0.067 |
IC50 = 80 nM |
PMID: 9003514 |
|
| ZINC01070102 |
agonist |
|
|
|
PMID: 9048584 |
|
| ZINC03814410 |
agonist |
4-hydroxyestradiol |
IC50 = 0.506 µM |
EC50 = 65.4 nM |
PMID: 9371241 |
|
| ZINC00056434 |
agonist |
bisphenol A |
|
EC50 = 0.4 µM |
PMID: 9658195 |
|
| ZINC00585979 |
agonist |
17-epiestriol |
|
EC50 = 72 nM |
PMID: 9658195 |
|
| ZINC00056546 |
agonist |
hexestrol |
Kd = 0.3 nM |
|
PMID: 9717838 |
|
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